Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation MAX

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
HOXD1up-regulatesR-1302-0.0406426Pr-137
ESRRAdown-regulatesR-27470.0501381Pr-35
ZNF740down-regulatesR-388-0.0546517Pr-118
CREB1down-regulatesR-2710.0973451Pr-1
ZNF740down-regulatesR-3860.111482Pr-58
MEF2Adown-regulatesR-18760.111678Pr-137
TP53down-regulatesR-3760.127114Pr-38
RFX3down-regulatesR-16660.128531Pr-138
FLI1down-regulatesR-790-0.135687Pr-137
NFIL3down-regulatesR-1686-0.145704Pr-25
FLI1down-regulatesR-7820.152239Pr-137
TP53down-regulatesR-373-0.181773Pr-130
ZBTB16down-regulatesR-5890.185533Pr-125
BBXdown-regulatesR-15380.245813Pr-125
PARP1up-regulatesR-26390.255441Pr-4
NFKB1down-regulatesR-1579-0.260085Pr-137
TP53down-regulatesR-374-0.289282Pr-104
ATF1up-regulatesR-5640.297759Pr-93
SF1down-regulatesR-1907-0.317014Pr-3
RARAdown-regulatesR-160-0.331894Pr-25
CEBPBup-regulatesR-1768-0.337185Pr-109
XBP1up-regulatesR-30590.341163Pr-35
ENSG00000177374down-regulatesR-23640.342897Pr-139
ERFdown-regulatesR-3360.343262Pr-35
TRAF4down-regulatesR-3043-0.355413Pr-4
IRF4down-regulatesR-4910.365902Pr-88
TP53down-regulatesR-369-0.383401Pr-117
HMGA1down-regulatesR-8320.407077Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

KLF4up-regulatesR-2758-0.426292Pr-129
ETS1down-regulatesR-12-0.427939Pr-60
TFCP2down-regulatesR-1702-0.433807Pr-110
HINFPdown-regulatesR-2624-0.44835Pr-35
BBXdown-regulatesR-1534-0.482476Pr-9
MEF2Adown-regulatesR-1866-0.518528Pr-3
MEF2Adown-regulatesR-18860.552959Pr-129
XBP1up-regulatesR-30520.559099Pr-108
MEF2Adown-regulatesR-18720.561055Pr-56
HSF1down-regulatesR-540.604731Pr-125
CEBPBup-regulatesR-1767-0.661208Pr-4
FLI1down-regulatesR-786-0.733394Pr-59
MEF2Adown-regulatesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

HSF1down-regulatesR-51-0.803656Pr-19
ETS1down-regulatesR-7-0.82093Pr-64
XBP1up-regulatesR-3065-0.830078Pr-65
CEBPBup-regulatesR-1777-0.838666Pr-129
RARAdown-regulatesR-159-0.860941Pr-9
HSF1down-regulatesR-52-0.875962Pr-9
ETS1down-regulatesR-4-0.886127Pr-9
EGR1down-regulatesR-2901-0.911846Pr-20
ETS1down-regulatesR-14-0.914198Pr-35
ERFdown-regulatesR-3310.969151Pr-136
NFKB1down-regulatesR-1578-0.969867Pr-65
ETS1down-regulatesR-00.98535Pr-136
ESRRAdown-regulatesR-27380.991373Pr-117
NFATC1down-regulatesR-2207-1.00385Pr-15
TCF3up-regulatesR-20591.02628Pr-56
NFKB1down-regulatesR-1585-1.04936Pr-4
CREB1down-regulatesR-273-1.05492Pr-9
TRAF4down-regulatesR-30341.06768Pr-124
ZNF691up-regulatesR-30111.09639Pr-138
HINFPdown-regulatesR-2625-1.11022Pr-118
MYCdown-regulatesR-20691.14857Pr-117
TCF3up-regulatesR-2062-1.17031Pr-102
SOX4up-regulatesR-21791.18112Pr-117
DLX4up-regulatesR-1988-1.19988Pr-137
ERFdown-regulatesR-333-1.22378Pr-3
DLX4up-regulatesR-1987-1.23929Pr-86
MEF2Adown-regulatesR-1878-1.24921Pr-9
ENSG00000136574up-regulatesR-391.25412Pr-124
RFX3down-regulatesR-1672-1.25932Pr-140

Genes (2)

CALR, ENTPD6

Regulons (4)

R-1157, R-1672, R-2042, R-1823

ATF2up-regulatesR-30921.26346Pr-111
KLF13down-regulatesR-2041-1.31925Pr-42
SATB1down-regulatesR-1079-1.37895Pr-109
TP53down-regulatesR-3681.38025Pr-88
NFKB1down-regulatesR-1583-1.38564Pr-9
ETS1down-regulatesR-81.3888Pr-96
E2F2up-regulatesR-29491.40408Pr-16
NFKB1down-regulatesR-1593-1.40749Pr-15
ESRRAdown-regulatesR-2737-1.42424Pr-15
FLI1down-regulatesR-789-1.43137Pr-19
TCF3up-regulatesR-2061-1.44773Pr-9
HMGA1down-regulatesR-825-1.46299Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

IRX3down-regulatesR-22271.47781Pr-16
CREB1down-regulatesR-277-1.54447Pr-35
ZNF219up-regulatesR-2211-1.56166Pr-86
ETS1down-regulatesR-2-1.58579Pr-19
HMGA1down-regulatesR-8221.59236Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ETS1down-regulatesR-1-1.61913Pr-64
ESRRAdown-regulatesR-2748-1.63423Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ZBTB16down-regulatesR-582-1.65525Pr-105
NFKB2down-regulatesR-2824-1.72295Pr-4
RFX7down-regulatesR-2750-1.73199Pr-118
XBP1up-regulatesR-3055-1.75771Pr-28
HSF1down-regulatesR-56-1.77472Pr-36
E2F2up-regulatesR-2947-1.79304Pr-102
MYCdown-regulatesR-20701.79678Pr-117
NFKB1down-regulatesR-1580-1.81925Pr-91
ATF1up-regulatesR-560-1.81953Pr-4
SATB1down-regulatesR-1075-1.88885Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

CEBPBup-regulatesR-1763-1.95423Pr-103
RFX3down-regulatesR-16752.03925Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

RFX3down-regulatesR-1678-2.04824Pr-22
HINFPdown-regulatesR-2623-2.10028Pr-110
TCF3up-regulatesR-2056-2.11546Pr-91
CEBPBup-regulatesR-17762.1174Pr-139
BARX2down-regulatesR-2912.13395Pr-137
CREB1down-regulatesR-270-2.13915Pr-4
ZC3H11Adown-regulatesR-1141-2.14904Pr-86
FLI1down-regulatesR-7842.19671Pr-137
ENSG00000136574up-regulatesR-36-2.24791Pr-15
HINFPdown-regulatesR-2628-2.29875Pr-42
HMGA1down-regulatesR-8342.30843Pr-136
ZNF691up-regulatesR-30052.31507Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

HMGA1down-regulatesR-818-2.31588Pr-4
NFKB1down-regulatesR-1573-2.35352Pr-4
RARAdown-regulatesR-167-2.36681Pr-3
SATB1down-regulatesR-1081-2.38195Pr-104
BBXdown-regulatesR-15332.412Pr-137
RARAdown-regulatesR-1692.42125Pr-138
BARX2down-regulatesR-292-2.43197Pr-101
ERFdown-regulatesR-3352.46806Pr-136
ETV2down-regulatesR-1510-2.52918Pr-36
ERFdown-regulatesR-329-2.5417Pr-36
ETV2down-regulatesR-15082.5634Pr-59
ENSG00000136574up-regulatesR-33-2.57564Pr-86
KLF4up-regulatesR-2755-2.59765Pr-110
MEF2Adown-regulatesR-1867-2.61348Pr-86
ENSG00000176887up-regulatesR-1898-2.61611Pr-36
HMGA1down-regulatesR-830-2.65695Pr-109
IRX3down-regulatesR-2221-2.68405Pr-4
RFX3down-regulatesR-1674-2.69724Pr-19
TCF3up-regulatesR-2050-2.70711Pr-86
MYCdown-regulatesR-2071-2.71972Pr-85
TCF3up-regulatesR-2049-2.72112Pr-15
NFATC1down-regulatesR-2202-2.7244Pr-19
ZNF740down-regulatesR-3822.73739Pr-108
FLI1down-regulatesR-7952.77664Pr-50
ENSG00000179348down-regulatesR-1064-2.78126Pr-19
ENSG00000177374down-regulatesR-2362-2.78315Pr-91
ETV2down-regulatesR-1507-2.80802Pr-36
NFIL3down-regulatesR-1684-2.82079Pr-4
NR3C1down-regulatesR-3182-2.83908Pr-101
XBP1up-regulatesR-3051-2.85107Pr-4
TP53down-regulatesR-375-2.85782Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

ENSG00000175832up-regulatesR-313-2.85877Pr-101
NFKB1down-regulatesR-1587-2.87374Pr-86
KLF4up-regulatesR-27562.89635Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

NFKB1down-regulatesR-1576-2.95247Pr-86
ERFdown-regulatesR-330-2.95847Pr-101
HINFPdown-regulatesR-2621-2.97505Pr-35
KLF4up-regulatesR-2752-2.99913Pr-36
FLI1down-regulatesR-787-3.00169Pr-118
E2F2up-regulatesR-2948-3.01545Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NFATC1down-regulatesR-22033.03435Pr-127
ENSG00000175832up-regulatesR-312-3.06Pr-36
ENSG00000179348down-regulatesR-10653.08491Pr-50
ZNF219up-regulatesR-2213-3.11551Pr-118
FLI1down-regulatesR-780-3.11957Pr-36
MEF2Adown-regulatesR-1877-3.20022Pr-38
EGR1down-regulatesR-2896-3.20252Pr-61
NFKB1down-regulatesR-1589-3.21935Pr-3
ENSG00000128652up-regulatesR-22593.22334Pr-108
MZF1down-regulatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NR3C1down-regulatesR-3189-3.2767Pr-20
TEFdown-regulatesR-2406-3.30554Pr-135
ENSG00000128652up-regulatesR-22623.31057Pr-108
NR3C1down-regulatesR-31883.34354Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ZNF219up-regulatesR-22103.3532Pr-8
ZNF219up-regulatesR-22093.35607Pr-108
RARAdown-regulatesR-149-3.36184Pr-15
MZF1down-regulatesR-3019-3.42244Pr-35
ENSG00000176887up-regulatesR-18923.42989Pr-122
IRF4down-regulatesR-493-3.47489Pr-35
ESRRAdown-regulatesR-2743-3.48448Pr-86
CEBPBup-regulatesR-17593.59248Pr-108
RARAdown-regulatesR-166-3.60154Pr-20
RFX3down-regulatesR-16683.60705Pr-138
ENSG00000136574up-regulatesR-343.74664Pr-108
CEBPBup-regulatesR-1775-3.79192Pr-36
ENSG00000177374down-regulatesR-23633.91579Pr-108
CEBPBup-regulatesR-1774-3.92486Pr-38
SP3up-regulatesR-1823-3.92809Pr-140

Genes (2)

CALR, ENTPD6

Regulons (4)

R-1157, R-1672, R-2042, R-1823

ENSG00000128652up-regulatesR-2263-3.97492Pr-135
E2F8up-regulatesR-16294.14363Pr-136
SOX4up-regulatesR-21784.19485Pr-108
MEF2Adown-regulatesR-18804.46094Pr-128
ENSG00000176887up-regulatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FLI1down-regulatesR-794-4.49758Pr-36
RFX3down-regulatesR-16654.55866Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ESRRAdown-regulatesR-2740-4.64571Pr-36
ENSG00000136574up-regulatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ERFdown-regulatesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

VDRdown-regulatesR-12315.12816Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ENSG00000128652up-regulatesR-22615.47173Pr-71
MAFup-regulatesR-1065.50825Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TCF3up-regulatesR-20487.44347Pr-71
PARP1up-regulatesR-26368.12838Pr-68
TCF3up-regulatesR-20468.47287Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F7up-regulatesR-13848.63788Pr-68
E2F8up-regulatesR-16288.73321Pr-71
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions