Program

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

Causal Mechanistic Flows with regulons in program Pr-119

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5up-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

DIS3down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

FAM46Cup-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

FGFR3down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

IRF4down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MAXdown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

NRASup-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

PRKD2down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

RNASeq_CCND3_Calldown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

RNASeq_FGFR3_Calldown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

RNASeq_MAFB_Calldown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MYCup-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(4;14)down-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

ROBO1up-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(4;14)_cytogeneticdown-regulatesHMGA1activatesR-8320.4070776Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

CMYA5down-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

DIS3up-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

KIAA1109down-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MUC16down-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)up-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MYCdown-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

TP53down-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)_cytogeneticup-regulatesJUNrepressesR-11810.9164849Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

ANK2down-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

CMYA5down-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

IRF4up-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

NEBdown-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)up-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MYCdown-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)_cytogeneticup-regulatesTHRArepressesR-581.192376Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

AHNAK2down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

CMYA5down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

DNAH5down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

IRF4up-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MACF1down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

NEBdown-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)up-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

SYNE1down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

TP53down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

del17down-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

del17pdown-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(11;14)_cytogeneticup-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

t(14;16)_cytogeneticdown-regulatesRARArepressesR-1641.2404610Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

Regulons in program Pr-119

Regulon Cox Hazard Ratio # genes # causal flows
R-8320.407077617
R-11810.91648498
R-581.1923767
R-1641.240461013

Genes in program Pr-119

EnsEMBL IdEntrez IdPreferred
ENSG00000179921 151306GPBAR1
ENSG00000187010 6007RHD
ENSG00000197045 2764GMFB
ENSG00000197405 728C5AR1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions