Program

Causal Mechanistic Flows with regulons in program Pr-44

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_MAFA_Calldown-regulatesFOXK1activatesR-1193-2.5614125Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

AHNAK2up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DIS3up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DNAH10up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46Cdown-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FGFR3up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NRASdown-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

PRKD2up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_Callup-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SETD2up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

TRAF3up-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticup-regulatesMAZrepressesR-513-2.965426Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

AHNAK2up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DCHS1up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DIS3up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46Cdown-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAT3up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MAXup-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MUC12up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_Callup-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_Callup-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(14;16)up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

ZNF462up-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticup-regulatesE2F2repressesR-2948-3.015456Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DSTup-regulatesFOXJ1activatesR-1851-3.049198Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FGFR3down-regulatesFOXJ1activatesR-1851-3.049198Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

IRF4down-regulatesFOXJ1activatesR-1851-3.049198Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_Calldown-regulatesFOXJ1activatesR-1851-3.049198Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DIS3down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DNAH10down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46Cup-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MAXdown-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NRASup-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

PRKD2down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_Calldown-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_Calldown-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(14;16)down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SETD2down-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticdown-regulatesMZF1activatesR-3018-3.2449913Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

DIS3down-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46Cup-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MACF1down-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_Calldown-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_Calldown-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)down-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SETD2down-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticdown-regulatesERFactivatesR-332-4.163788Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MXRA5down-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(11;14)down-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_Calldown-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

TP53down-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

ZNF462down-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(11;14)_cytogeneticdown-regulatesKLF7activatesR-280-4.3388413Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

Regulons in program Pr-44

Regulon Cox Hazard Ratio # genes # causal flows
R-1193-2.56141251
R-513-2.96542612
R-2948-3.01545613
R-1851-3.0491984
R-3018-3.244991312
R-332-4.1637888
R-280-4.33884136

Genes in program Pr-44

EnsEMBL IdEntrez IdPreferred

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions