Program

Causal Mechanistic Flows with regulons in program Pr-28

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesKLF7activatesR-287-0.6992786Pr-28
RNASeq_MAFA_Calldown-regulatesKLF7activatesR-287-0.6992786Pr-28
amp1qup-regulatesKLF7activatesR-287-0.6992786Pr-28
del13up-regulatesKLF7activatesR-287-0.6992786Pr-28
t(11;14)_cytogeneticdown-regulatesKLF7activatesR-287-0.6992786Pr-28
FAM46Cdown-regulatesZNF740repressesR-395-1.443186Pr-28
HUWE1up-regulatesZNF740repressesR-395-1.443186Pr-28
IRF4up-regulatesZNF740repressesR-395-1.443186Pr-28
KIAA1109down-regulatesZNF740repressesR-395-1.443186Pr-28
t(11;14)up-regulatesZNF740repressesR-395-1.443186Pr-28
RNASeq_CCND3_Callup-regulatesZNF740repressesR-395-1.443186Pr-28
amp1qdown-regulatesZNF740repressesR-395-1.443186Pr-28
t(11;14)_cytogeneticup-regulatesZNF740repressesR-395-1.443186Pr-28
DIS3down-regulatesKLF16activatesR-2698-1.73259Pr-28
EGR1up-regulatesKLF16activatesR-2698-1.73259Pr-28
FGFR3down-regulatesKLF16activatesR-2698-1.73259Pr-28
NRASup-regulatesKLF16activatesR-2698-1.73259Pr-28
t(11;14)down-regulatesKLF16activatesR-2698-1.73259Pr-28
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2698-1.73259Pr-28
t(4;14)down-regulatesKLF16activatesR-2698-1.73259Pr-28
ROBO1up-regulatesKLF16activatesR-2698-1.73259Pr-28
SIdown-regulatesKLF16activatesR-2698-1.73259Pr-28
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2698-1.73259Pr-28
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2698-1.73259Pr-28
MAXup-regulatesXBP1repressesR-3055-1.757719Pr-28
MYCdown-regulatesXBP1repressesR-3055-1.757719Pr-28
t(4;14)up-regulatesXBP1repressesR-3055-1.757719Pr-28
AHNAK2down-regulatesFOXK1activatesR-1202-1.9292111Pr-28
ASXL3down-regulatesFOXK1activatesR-1202-1.9292111Pr-28
TACC2down-regulatesFOXK1activatesR-1202-1.9292111Pr-28
amp1qup-regulatesFOXK1activatesR-1202-1.9292111Pr-28
del13up-regulatesFOXK1activatesR-1202-1.9292111Pr-28
AHNAK2down-regulatesFOXO1activatesR-1412-1.9765613Pr-28
BAI3down-regulatesFOXO1activatesR-1412-1.9765613Pr-28
FAT3down-regulatesFOXO1activatesR-1412-1.9765613Pr-28
MAGI1down-regulatesFOXO1activatesR-1412-1.9765613Pr-28
RNASeq_MAFA_Calldown-regulatesFOXO1activatesR-1412-1.9765613Pr-28
del13up-regulatesFOXO1activatesR-1412-1.9765613Pr-28
TACC2down-regulatesARID5AactivatesR-602-2.0629Pr-28
del13up-regulatesARID5AactivatesR-602-2.0629Pr-28

Regulons in program Pr-28

Regulon Cox Hazard Ratio # genes # causal flows
R-287-0.69927865
R-395-1.4431868
R-2698-1.7325911
R-3055-1.7577193
R-1202-1.92921115
R-1412-1.97656136
R-602-2.06292

Genes in program Pr-28

EnsEMBL IdEntrez IdPreferred
ENSG00000184381 8398PLA2G6
ENSG00000198818 113402SFT2D1
ENSG00000213465 402ARL2
ENSG00000213699 54978SLC35F6
ENSG00000221946 53822FXYD7
ENSG00000225968
ENSG00000237765 285550FAM200B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions