Program

Causal Mechanistic Flows with regulons in program Pr-130

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MAXdown-regulatesTP53activatesR-373-0.1817739Pr-130
RNASeq_FGFR3_Calldown-regulatesTP53activatesR-373-0.1817739Pr-130
MYCup-regulatesTP53activatesR-373-0.1817739Pr-130
t(4;14)down-regulatesTP53activatesR-373-0.1817739Pr-130
amp1qdown-regulatesTP53activatesR-373-0.1817739Pr-130
FGFR3up-regulatesMIXL1repressesR-26610.3427256Pr-130
RNASeq_FGFR3_Callup-regulatesMIXL1repressesR-26610.3427256Pr-130
t(4;14)up-regulatesMIXL1repressesR-26610.3427256Pr-130
t(4;14)_cytogeneticup-regulatesMIXL1repressesR-26610.3427256Pr-130
DIS3up-regulatesATF1activatesR-5650.5831668Pr-130
FAM46Cdown-regulatesATF1activatesR-5650.5831668Pr-130
t(11;14)up-regulatesATF1activatesR-5650.5831668Pr-130
DIS3up-regulatesNFYCactivatesR-3000.8140816Pr-130
FAM46Cdown-regulatesNFYCactivatesR-3000.8140816Pr-130
t(11;14)up-regulatesNFYCactivatesR-3000.8140816Pr-130
RNASeq_MAFB_Callup-regulatesNFYCactivatesR-3000.8140816Pr-130
t(11;14)_cytogeneticup-regulatesNFYCactivatesR-3000.8140816Pr-130
BRAFdown-regulatesSATB1repressesR-10801.005367Pr-130
DSTdown-regulatesSATB1repressesR-10801.005367Pr-130
PTPRDdown-regulatesSATB1repressesR-10801.005367Pr-130
RNASeq_FGFR3_Callup-regulatesSATB1repressesR-10801.005367Pr-130
t(4;14)up-regulatesSATB1repressesR-10801.005367Pr-130
SP140down-regulatesSATB1repressesR-10801.005367Pr-130
ZNF462down-regulatesSATB1repressesR-10801.005367Pr-130
t(4;14)_cytogeneticup-regulatesSATB1repressesR-10801.005367Pr-130
DIS3up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
FAT1up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
FGFR3up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
NRASdown-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
PCLOup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
RELNup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(11;14)down-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
RNASeq_FGFR3_Callup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(14;16)up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(4;14)up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
amp1qup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
del13up-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(11;14)_cytogeneticdown-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(14;16)_cytogeneticup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
t(4;14)_cytogeneticup-regulatesENSG00000087510repressesR-2631-1.778316Pr-130
DNAH10up-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
NEBdown-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
PCLOdown-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
t(11;14)up-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
RNASeq_CCND3_Callup-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
RNASeq_FGFR3_Calldown-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
t(4;14)down-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
t(11;14)_cytogeneticup-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
t(4;14)_cytogeneticdown-regulatesENSG00000162367activatesR-1714-3.264297Pr-130
AHNAK2down-regulatesFOXO1activatesR-1407-6.0469617Pr-130
DCHS1down-regulatesFOXO1activatesR-1407-6.0469617Pr-130
t(11;14)up-regulatesFOXO1activatesR-1407-6.0469617Pr-130

Regulons in program Pr-130

Regulon Cox Hazard Ratio # genes # causal flows
R-373-0.18177395
R-26610.34272564
R-5650.58316683
R-3000.81408165
R-10801.0053678
R-2631-1.77831615
R-1714-3.2642979
R-1407-6.04696173

Genes in program Pr-130

EnsEMBL IdEntrez IdPreferred
ENSG00000177169 8408ULK1
ENSG00000178999 9212AURKB
ENSG00000182584 170487ACTL10
ENSG00000185650 677ZFP36L1
ENSG00000188305 374872PEAK3
ENSG00000213928 10379IRF9

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions