Program

Causal Mechanistic Flows with regulons in program Pr-65

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DMDdown-regulatesXBP1activatesR-3065-0.8300786Pr-65
MAXup-regulatesXBP1activatesR-3065-0.8300786Pr-65
RNASeq_MAFA_Calldown-regulatesXBP1activatesR-3065-0.8300786Pr-65
MYCdown-regulatesXBP1activatesR-3065-0.8300786Pr-65
t(4;14)up-regulatesXBP1activatesR-3065-0.8300786Pr-65
del1pdown-regulatesXBP1activatesR-3065-0.8300786Pr-65
BAI3down-regulatesNFKB1repressesR-1578-0.96986717Pr-65
DIS3down-regulatesNFKB1repressesR-1578-0.96986717Pr-65
FAT3down-regulatesNFKB1repressesR-1578-0.96986717Pr-65
MAXdown-regulatesNFKB1repressesR-1578-0.96986717Pr-65
MYO10down-regulatesNFKB1repressesR-1578-0.96986717Pr-65
SVILdown-regulatesNFKB1repressesR-1578-0.96986717Pr-65
t(4;14)_cytogeneticdown-regulatesNFKB1repressesR-1578-0.96986717Pr-65
DIS3down-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
FAM46Cup-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
IRF4down-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
PRKD2down-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
t(11;14)down-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
RNASeq_CCND3_Calldown-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
t(11;14)_cytogeneticdown-regulatesENSG00000168269repressesR-1566-1.6341411Pr-65
RNASeq_CCND2_Callup-regulatesTEFactivatesR-2408-1.646448Pr-65
t(14;16)down-regulatesTEFactivatesR-2408-1.646448Pr-65
amp1qdown-regulatesTEFactivatesR-2408-1.646448Pr-65
del13down-regulatesTEFactivatesR-2408-1.646448Pr-65
IRF4down-regulatesSPDEFrepressesR-1969-2.538498Pr-65
t(11;14)down-regulatesSPDEFrepressesR-1969-2.538498Pr-65
amp1qup-regulatesSPDEFrepressesR-1969-2.538498Pr-65
del13up-regulatesSPDEFrepressesR-1969-2.538498Pr-65
t(14;16)up-regulatesFOXP1repressesR-3143-2.548738Pr-65
amp1qup-regulatesFOXP1repressesR-3143-2.548738Pr-65
del13up-regulatesFOXP1repressesR-3143-2.548738Pr-65
t(11;14)down-regulatesRORArepressesR-2273-2.934258Pr-65
amp1qup-regulatesRORArepressesR-2273-2.934258Pr-65
del13up-regulatesRORArepressesR-2273-2.934258Pr-65
del1pup-regulatesRORArepressesR-2273-2.934258Pr-65

Regulons in program Pr-65

Regulon Cox Hazard Ratio # genes # causal flows
R-3065-0.83007866
R-1578-0.969867177
R-1566-1.63414117
R-2408-1.6464484
R-1969-2.5384984
R-3143-2.5487383
R-2273-2.9342584

Genes in program Pr-65

EnsEMBL IdEntrez IdPreferred
ENSG00000185811 10320IKZF1
ENSG00000187713 94107TMEM203
ENSG00000205177
ENSG00000205352 54458PRR13

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions