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Causal Mechanistic Flows with regulons in program Pr-121

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
FGFR3	up-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
KDM3B	down-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(11;14)	down-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
RNASeq_FGFR3_Call	up-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
RNASeq_MAFA_Call	down-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(14;16)	down-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
amp1q	up-regulates	ENSG00000135638	activates	R-1958	0.576875	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
AHNAK2	down-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
DNAH5	down-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
DST	down-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
IRF4	up-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
MAX	down-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
PRKD2	up-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(11;14)	up-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(11;14)_cytogenetic	up-regulates	RFX3	represses	R-1675	2.03925	7	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
AHNAK2	down-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
DNAH5	down-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
MACF1	down-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(11;14)	up-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(11;14)_cytogenetic	up-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
t(4;14)_cytogenetic	up-regulates	IKZF1	represses	R-996	2.22566	6	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996

Regulons in program Pr-121

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-1958	0.576875	6	7
R-1675	2.03925	7	8
R-996	2.22566	6	6

Genes in program Pr-121

EnsEMBL Id	Entrez Id	Preferred
ENSG00000182481	3838	KPNA2
ENSG00000235750	9674	KIAA0040
ENSG00000250565	90423	ATP6V1E2

Pr-121

Program 121

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Causal Mechanistic Flows with regulons in program Pr-121

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Regulons in program Pr-121

Genes in program Pr-121

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