Program

Causal Mechanistic Flows with regulons in program Pr-103

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3down-regulatesHOXA3activatesR-224-1.6640210Pr-103
IRF4down-regulatesHOXA3activatesR-224-1.6640210Pr-103
NEBup-regulatesHOXA3activatesR-224-1.6640210Pr-103
PRKD2down-regulatesHOXA3activatesR-224-1.6640210Pr-103
t(11;14)down-regulatesHOXA3activatesR-224-1.6640210Pr-103
RNASeq_FGFR3_Calldown-regulatesHOXA3activatesR-224-1.6640210Pr-103
t(4;14)down-regulatesHOXA3activatesR-224-1.6640210Pr-103
t(11;14)_cytogeneticdown-regulatesHOXA3activatesR-224-1.6640210Pr-103
t(4;14)_cytogeneticdown-regulatesHOXA3activatesR-224-1.6640210Pr-103
DCHS1up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
DIS3up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
FAM46Cdown-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
FGFR3up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
HUWE1up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
IRF4up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
MAXup-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
NRASdown-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
PRKD2up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
t(11;14)up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
RNASeq_FGFR3_Callup-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
t(4;14)up-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
t(11;14)_cytogeneticup-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
t(4;14)_cytogeneticup-regulatesCEBPBrepressesR-1763-1.9542313Pr-103
NEBdown-regulatesZNF281repressesR-2481-2.5205416Pr-103
t(11;14)up-regulatesZNF281repressesR-2481-2.5205416Pr-103
RNASeq_FGFR3_Callup-regulatesZNF281repressesR-2481-2.5205416Pr-103
t(4;14)up-regulatesZNF281repressesR-2481-2.5205416Pr-103
t(11;14)_cytogeneticup-regulatesZNF281repressesR-2481-2.5205416Pr-103
DIS3up-regulatesIRF9repressesR-1153-2.6533417Pr-103
FGFR3up-regulatesIRF9repressesR-1153-2.6533417Pr-103
RNASeq_FGFR3_Callup-regulatesIRF9repressesR-1153-2.6533417Pr-103
DIS3up-regulatesRFX3repressesR-1664-2.8373111Pr-103
DNAH10up-regulatesRFX3repressesR-1664-2.8373111Pr-103
FAM46Cdown-regulatesRFX3repressesR-1664-2.8373111Pr-103
FGFR3up-regulatesRFX3repressesR-1664-2.8373111Pr-103
IRF4up-regulatesRFX3repressesR-1664-2.8373111Pr-103
KIAA1244down-regulatesRFX3repressesR-1664-2.8373111Pr-103
NEBdown-regulatesRFX3repressesR-1664-2.8373111Pr-103
PRKD2up-regulatesRFX3repressesR-1664-2.8373111Pr-103
t(11;14)up-regulatesRFX3repressesR-1664-2.8373111Pr-103
RNASeq_FGFR3_Callup-regulatesRFX3repressesR-1664-2.8373111Pr-103
t(4;14)up-regulatesRFX3repressesR-1664-2.8373111Pr-103
TRAF3down-regulatesRFX3repressesR-1664-2.8373111Pr-103
t(11;14)_cytogeneticup-regulatesRFX3repressesR-1664-2.8373111Pr-103
t(4;14)_cytogeneticup-regulatesRFX3repressesR-1664-2.8373111Pr-103
t(11;14)up-regulatesTCF7L1repressesR-3172-2.844867Pr-103
del13up-regulatesTCF7L1repressesR-3172-2.844867Pr-103
NEBdown-regulatesBACH1repressesR-475-3.08297Pr-103
t(11;14)up-regulatesBACH1repressesR-475-3.08297Pr-103
RNASeq_FGFR3_Callup-regulatesBACH1repressesR-475-3.08297Pr-103
t(14;16)up-regulatesBACH1repressesR-475-3.08297Pr-103
t(4;14)up-regulatesBACH1repressesR-475-3.08297Pr-103
amp1qup-regulatesBACH1repressesR-475-3.08297Pr-103
del13up-regulatesBACH1repressesR-475-3.08297Pr-103
t(11;14)_cytogeneticup-regulatesBACH1repressesR-475-3.08297Pr-103
DIS3down-regulatesTP53activatesR-365-3.1290312Pr-103
FAM46Cup-regulatesTP53activatesR-365-3.1290312Pr-103
FGFR3down-regulatesTP53activatesR-365-3.1290312Pr-103
t(11;14)down-regulatesTP53activatesR-365-3.1290312Pr-103
RNASeq_FGFR3_Calldown-regulatesTP53activatesR-365-3.1290312Pr-103
t(14;16)down-regulatesTP53activatesR-365-3.1290312Pr-103
t(4;14)down-regulatesTP53activatesR-365-3.1290312Pr-103
amp1qdown-regulatesTP53activatesR-365-3.1290312Pr-103
del13down-regulatesTP53activatesR-365-3.1290312Pr-103
t(4;14)_cytogeneticdown-regulatesTP53activatesR-365-3.1290312Pr-103
MXRA5down-regulatesTFCP2activatesR-1701-3.472478Pr-103
DIS3down-regulatesMZF1activatesR-3023-3.636588Pr-103
DNAH10down-regulatesMZF1activatesR-3023-3.636588Pr-103
FAM46Cup-regulatesMZF1activatesR-3023-3.636588Pr-103
FGFR3down-regulatesMZF1activatesR-3023-3.636588Pr-103
IRF4down-regulatesMZF1activatesR-3023-3.636588Pr-103
KIAA1244up-regulatesMZF1activatesR-3023-3.636588Pr-103
NRASup-regulatesMZF1activatesR-3023-3.636588Pr-103
PRKD2down-regulatesMZF1activatesR-3023-3.636588Pr-103
t(11;14)down-regulatesMZF1activatesR-3023-3.636588Pr-103
RNASeq_FGFR3_Calldown-regulatesMZF1activatesR-3023-3.636588Pr-103
RNASeq_MAFA_Calldown-regulatesMZF1activatesR-3023-3.636588Pr-103
t(14;16)down-regulatesMZF1activatesR-3023-3.636588Pr-103
t(4;14)down-regulatesMZF1activatesR-3023-3.636588Pr-103
t(11;14)_cytogeneticdown-regulatesMZF1activatesR-3023-3.636588Pr-103
t(4;14)_cytogeneticdown-regulatesMZF1activatesR-3023-3.636588Pr-103

Regulons in program Pr-103

Regulon Cox Hazard Ratio # genes # causal flows
R-224-1.66402109
R-1763-1.954231314
R-2481-2.52054165
R-1153-2.65334173
R-1664-2.837311114
R-3172-2.8448672
R-475-3.082978
R-365-3.129031210
R-1701-3.4724781
R-3023-3.63658815

Genes in program Pr-103

EnsEMBL IdEntrez IdPreferred
ENSG00000205581 3150HMGN1
ENSG00000224420 199800ADM5

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions