Program

Causal Mechanistic Flows with regulons in program Pr-86

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FAT3down-regulatesELF2activatesR-968-1.1736914Pr-86
del13up-regulatesELF2activatesR-968-1.1736914Pr-86
CYLDdown-regulatesDLX4repressesR-1987-1.239297Pr-86
MAXup-regulatesDLX4repressesR-1987-1.239297Pr-86
ATMup-regulatesNR3C1activatesR-3193-1.453717Pr-86
CACNA1Hup-regulatesNR3C1activatesR-3193-1.453717Pr-86
FAT3down-regulatesNR3C1activatesR-3193-1.453717Pr-86
NRASdown-regulatesNR3C1activatesR-3193-1.453717Pr-86
PCDH10down-regulatesNR3C1activatesR-3193-1.453717Pr-86
PRDM1up-regulatesNR3C1activatesR-3193-1.453717Pr-86
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-3193-1.453717Pr-86
RNASeq_MAFB_Callup-regulatesNR3C1activatesR-3193-1.453717Pr-86
t(14;16)up-regulatesNR3C1activatesR-3193-1.453717Pr-86
SP140up-regulatesNR3C1activatesR-3193-1.453717Pr-86
ZNF208down-regulatesNR3C1activatesR-3193-1.453717Pr-86
del13up-regulatesNR3C1activatesR-3193-1.453717Pr-86
t(14;16)_cytogeneticup-regulatesNR3C1activatesR-3193-1.453717Pr-86
CACNA1Hdown-regulatesZNF219repressesR-2211-1.5616613Pr-86
KIAA1244down-regulatesZNF219repressesR-2211-1.5616613Pr-86
MAXup-regulatesZNF219repressesR-2211-1.5616613Pr-86
t(11;14)up-regulatesZNF219repressesR-2211-1.5616613Pr-86
RNASeq_CCND2_Callup-regulatesZNF219repressesR-2211-1.5616613Pr-86
RNASeq_FGFR3_Callup-regulatesZNF219repressesR-2211-1.5616613Pr-86
t(11;14)_cytogeneticup-regulatesZNF219repressesR-2211-1.5616613Pr-86
NRASup-regulatesTP53repressesR-379-1.627336Pr-86
t(14;16)down-regulatesTP53repressesR-379-1.627336Pr-86
amp1qdown-regulatesTP53repressesR-379-1.627336Pr-86
del13down-regulatesTP53repressesR-379-1.627336Pr-86
RNASeq_MAFA_Callup-regulatesZEB1activatesR-2240-1.7504216Pr-86
t(14;16)up-regulatesZEB1activatesR-2240-1.7504216Pr-86
amp1qup-regulatesZEB1activatesR-2240-1.7504216Pr-86
del13up-regulatesZEB1activatesR-2240-1.7504216Pr-86
FAT3down-regulatesCEBPGactivatesR-452-1.910696Pr-86
PCDH10down-regulatesCEBPGactivatesR-452-1.910696Pr-86
amp1qup-regulatesCEBPGactivatesR-452-1.910696Pr-86
del13up-regulatesCEBPGactivatesR-452-1.910696Pr-86
DNAH5down-regulatesSTAT4activatesR-2649-2.0752420Pr-86
RNASeq_MAFA_Callup-regulatesSTAT4activatesR-2649-2.0752420Pr-86
t(14;16)up-regulatesSTAT4activatesR-2649-2.0752420Pr-86
MAXdown-regulatesZC3H11AactivatesR-1141-2.149046Pr-86
RNASeq_FGFR3_Calldown-regulatesZC3H11AactivatesR-1141-2.149046Pr-86
t(4;14)down-regulatesZC3H11AactivatesR-1141-2.149046Pr-86
amp1qup-regulatesZC3H11AactivatesR-1141-2.149046Pr-86
AHNAK2down-regulatesTRAF4activatesR-3044-2.170556Pr-86
FAT3down-regulatesTRAF4activatesR-3044-2.170556Pr-86
PCDH10down-regulatesTRAF4activatesR-3044-2.170556Pr-86
DIS3up-regulatesSTAT5AactivatesR-2159-2.2500117Pr-86
RNASeq_MAFA_Callup-regulatesSTAT5AactivatesR-2159-2.2500117Pr-86
t(14;16)up-regulatesSTAT5AactivatesR-2159-2.2500117Pr-86
amp1qup-regulatesSTAT5AactivatesR-2159-2.2500117Pr-86
t(4;14)up-regulatesIKZF1activatesR-992-2.4305813Pr-86
amp1qup-regulatesIKZF1activatesR-992-2.4305813Pr-86
del13up-regulatesIKZF1activatesR-992-2.4305813Pr-86
AHNAK2down-regulatesFOXJ3activatesR-2877-2.4351735Pr-86
CMYA5down-regulatesFOXJ3activatesR-2877-2.4351735Pr-86
DNAH5down-regulatesFOXJ3activatesR-2877-2.4351735Pr-86
amp1qup-regulatesFOXJ3activatesR-2877-2.4351735Pr-86
del13up-regulatesFOXJ3activatesR-2877-2.4351735Pr-86
ABCA13down-regulatesFOXJ2activatesR-1422-2.4700134Pr-86
AHNAK2down-regulatesFOXJ2activatesR-1422-2.4700134Pr-86
t(14;16)up-regulatesFOXJ2activatesR-1422-2.4700134Pr-86
amp1qup-regulatesFOXJ2activatesR-1422-2.4700134Pr-86
del13up-regulatesFOXJ2activatesR-1422-2.4700134Pr-86
CYLDdown-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
MAXup-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
NFKB2down-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
RNASeq_MAFA_Calldown-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
t(14;16)down-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
ROBO1down-regulatesENSG00000136574repressesR-33-2.5756418Pr-86
AHNAK2down-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
FAT3down-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
MAXdown-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
RNASeq_CCND2_Calldown-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
amp1qup-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
del13up-regulatesMEF2AactivatesR-1867-2.6134834Pr-86
t(14;16)up-regulatesEWSR1activatesR-2544-2.6360127Pr-86
amp1qup-regulatesEWSR1activatesR-2544-2.6360127Pr-86
del13up-regulatesEWSR1activatesR-2544-2.6360127Pr-86
ABCA13up-regulatesTCF3repressesR-2050-2.7071138Pr-86
CYLDdown-regulatesTCF3repressesR-2050-2.7071138Pr-86
MAXup-regulatesTCF3repressesR-2050-2.7071138Pr-86
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-2050-2.7071138Pr-86
t(14;16)down-regulatesTCF3repressesR-2050-2.7071138Pr-86
ZNF208up-regulatesTCF3repressesR-2050-2.7071138Pr-86
CSMD1up-regulatesSREBF1activatesR-1136-2.8439612Pr-86
NRASdown-regulatesSREBF1activatesR-1136-2.8439612Pr-86
RNASeq_MAFA_Callup-regulatesSREBF1activatesR-1136-2.8439612Pr-86
RNASeq_MAFB_Callup-regulatesSREBF1activatesR-1136-2.8439612Pr-86
t(14;16)up-regulatesSREBF1activatesR-1136-2.8439612Pr-86
amp1qup-regulatesSREBF1activatesR-1136-2.8439612Pr-86
del13up-regulatesSREBF1activatesR-1136-2.8439612Pr-86
del1pup-regulatesSREBF1activatesR-1136-2.8439612Pr-86
t(14;16)_cytogeneticup-regulatesSREBF1activatesR-1136-2.8439612Pr-86
FAT3down-regulatesNFKB1activatesR-1587-2.873747Pr-86
MAXdown-regulatesNFKB1activatesR-1587-2.873747Pr-86
PCDH10down-regulatesNFKB1activatesR-1587-2.873747Pr-86
RNASeq_CCND2_Calldown-regulatesNFKB1activatesR-1587-2.873747Pr-86
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1587-2.873747Pr-86
t(4;14)down-regulatesNFKB1activatesR-1587-2.873747Pr-86
t(4;14)_cytogeneticdown-regulatesNFKB1activatesR-1587-2.873747Pr-86
FAT3down-regulatesZNF281activatesR-2478-2.9378724Pr-86
del13up-regulatesZNF281activatesR-2478-2.9378724Pr-86
FAT3down-regulatesNFKB1activatesR-1576-2.9524721Pr-86
MAXdown-regulatesNFKB1activatesR-1576-2.9524721Pr-86
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1576-2.9524721Pr-86
t(4;14)down-regulatesNFKB1activatesR-1576-2.9524721Pr-86
t(11;14)down-regulatesKLF16activatesR-2693-2.9535514Pr-86
ROBO1up-regulatesKLF16activatesR-2693-2.9535514Pr-86
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2693-2.9535514Pr-86
LRP2down-regulatesSPI1activatesR-2605-2.9878731Pr-86
AHNAK2down-regulatesSMAD4activatesR-2355-3.442569Pr-86
CMYA5down-regulatesSMAD4activatesR-2355-3.442569Pr-86
DNAH5down-regulatesSMAD4activatesR-2355-3.442569Pr-86
LRP2down-regulatesSMAD4activatesR-2355-3.442569Pr-86
NRASdown-regulatesSMAD4activatesR-2355-3.442569Pr-86
PKHD1L1down-regulatesSMAD4activatesR-2355-3.442569Pr-86
t(14;16)up-regulatesSMAD4activatesR-2355-3.442569Pr-86
ZNF208down-regulatesSMAD4activatesR-2355-3.442569Pr-86
FGFR3down-regulatesESRRAactivatesR-2743-3.484488Pr-86
IRF4down-regulatesESRRAactivatesR-2743-3.484488Pr-86
MAXdown-regulatesESRRAactivatesR-2743-3.484488Pr-86
PRKD2down-regulatesESRRAactivatesR-2743-3.484488Pr-86
t(11;14)down-regulatesESRRAactivatesR-2743-3.484488Pr-86
RNASeq_FGFR3_Calldown-regulatesESRRAactivatesR-2743-3.484488Pr-86
t(4;14)down-regulatesESRRAactivatesR-2743-3.484488Pr-86
t(11;14)_cytogeneticdown-regulatesESRRAactivatesR-2743-3.484488Pr-86
t(4;14)_cytogeneticdown-regulatesESRRAactivatesR-2743-3.484488Pr-86
AHNAK2down-regulatesZEB1activatesR-2253-3.488036Pr-86
PCDH10down-regulatesZEB1activatesR-2253-3.488036Pr-86
t(11;14)down-regulatesZEB1activatesR-2253-3.488036Pr-86
RNASeq_MAFA_Callup-regulatesZEB1activatesR-2253-3.488036Pr-86
t(14;16)up-regulatesZEB1activatesR-2253-3.488036Pr-86
del13up-regulatesZEB1activatesR-2253-3.488036Pr-86
t(11;14)_cytogeneticdown-regulatesZEB1activatesR-2253-3.488036Pr-86
t(11;14)down-regulatesRORAactivatesR-2270-3.514828Pr-86
del13up-regulatesRORAactivatesR-2270-3.514828Pr-86

Regulons in program Pr-86

Regulon Cox Hazard Ratio # genes # causal flows
R-968-1.17369142
R-1987-1.2392972
R-3193-1.45371713
R-2211-1.56166137
R-379-1.6273364
R-2240-1.75042164
R-452-1.9106964
R-2649-2.07524203
R-1141-2.1490464
R-3044-2.1705563
R-2159-2.25001174
R-992-2.43058133
R-2877-2.43517355
R-1422-2.47001345
R-33-2.57564186
R-1867-2.61348346
R-2544-2.63601273
R-2050-2.70711386
R-1136-2.84396129
R-1587-2.8737477
R-2478-2.93787242
R-1576-2.95247214
R-2693-2.95355143
R-2605-2.98787311
R-2355-3.4425698
R-2743-3.4844889
R-2253-3.4880367
R-2270-3.5148282

Genes in program Pr-86

EnsEMBL IdEntrez IdPreferred
ENSG00000196914 23365ARHGEF12
ENSG00000197386 3064HTT
ENSG00000198841 112970KTI12
ENSG00000204178 55219MACO1
ENSG00000205089 645121CCNI2
ENSG00000213625 54741LEPROT
ENSG00000221890
ENSG00000239779 23559WBP1
ENSG00000243789 100137047JMJD7
ENSG00000244405 2119ETV5
ENSG00000253846 56106PCDHGA10
ENSG00000102878 3299HSF4
ENSG00000130726 10155TRIM28
ENSG00000185155 83881MIXL1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions