Program

Causal Mechanistic Flows with regulons in program Pr-60

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ACTG1down-regulatesETS1repressesR-12-0.4279396Pr-60
CACNA1Hup-regulatesETS1repressesR-12-0.4279396Pr-60
CYLDup-regulatesETS1repressesR-12-0.4279396Pr-60
DSCAML1up-regulatesETS1repressesR-12-0.4279396Pr-60
FGFR3down-regulatesETS1repressesR-12-0.4279396Pr-60
KIAA1244up-regulatesETS1repressesR-12-0.4279396Pr-60
KRASdown-regulatesETS1repressesR-12-0.4279396Pr-60
MAXdown-regulatesETS1repressesR-12-0.4279396Pr-60
NFKB2up-regulatesETS1repressesR-12-0.4279396Pr-60
PRKD2down-regulatesETS1repressesR-12-0.4279396Pr-60
RNASeq_CCND2_Calldown-regulatesETS1repressesR-12-0.4279396Pr-60
RNASeq_FGFR3_Calldown-regulatesETS1repressesR-12-0.4279396Pr-60
RNASeq_MAFA_Callup-regulatesETS1repressesR-12-0.4279396Pr-60
RNASeq_MAFB_Callup-regulatesETS1repressesR-12-0.4279396Pr-60
t(14;16)up-regulatesETS1repressesR-12-0.4279396Pr-60
t(4;14)down-regulatesETS1repressesR-12-0.4279396Pr-60
t(4;14)_cytogeneticdown-regulatesETS1repressesR-12-0.4279396Pr-60
CSMD1down-regulatesKLF4activatesR-27530.46126515Pr-60
CYLDdown-regulatesKLF4activatesR-27530.46126515Pr-60
DIS3up-regulatesKLF4activatesR-27530.46126515Pr-60
DSTdown-regulatesKLF4activatesR-27530.46126515Pr-60
FGFR3up-regulatesKLF4activatesR-27530.46126515Pr-60
MUC16down-regulatesKLF4activatesR-27530.46126515Pr-60
NFKB2down-regulatesKLF4activatesR-27530.46126515Pr-60
RNASeq_FGFR3_Callup-regulatesKLF4activatesR-27530.46126515Pr-60
MYCdown-regulatesKLF4activatesR-27530.46126515Pr-60
t(4;14)up-regulatesKLF4activatesR-27530.46126515Pr-60
t(4;14)_cytogeneticup-regulatesKLF4activatesR-27530.46126515Pr-60
FGFR3up-regulatesENSG00000175832activatesR-3140.4628216Pr-60
IRF4up-regulatesENSG00000175832activatesR-3140.4628216Pr-60
NFKB2down-regulatesENSG00000175832activatesR-3140.4628216Pr-60
t(11;14)up-regulatesENSG00000175832activatesR-3140.4628216Pr-60
t(4;14)up-regulatesENSG00000175832activatesR-3140.4628216Pr-60
t(11;14)_cytogeneticup-regulatesENSG00000175832activatesR-3140.4628216Pr-60
AHNAK2down-regulatesEP300activatesR-24330.5371467Pr-60
t(11;14)up-regulatesEP300activatesR-24330.5371467Pr-60
AHNAK2down-regulatesFOXO1activatesR-14110.5846714Pr-60
MACF1down-regulatesFOXO1activatesR-14110.5846714Pr-60
MYO10down-regulatesFOXO1activatesR-14110.5846714Pr-60
NEBdown-regulatesFOXO1activatesR-14110.5846714Pr-60
PTPRDdown-regulatesFOXO1activatesR-14110.5846714Pr-60
t(11;14)up-regulatesFOXO1activatesR-14110.5846714Pr-60
RNASeq_MAFA_Calldown-regulatesFOXO1activatesR-14110.5846714Pr-60
RNASeq_MAFB_Calldown-regulatesFOXO1activatesR-14110.5846714Pr-60
t(14;16)_cytogeneticdown-regulatesFOXO1activatesR-14110.5846714Pr-60
AHNAK2down-regulatesSMAD4activatesR-2357-0.6424258Pr-60
CMYA5down-regulatesSMAD4activatesR-2357-0.6424258Pr-60
DNAH5down-regulatesSMAD4activatesR-2357-0.6424258Pr-60
PKHD1L1down-regulatesSMAD4activatesR-2357-0.6424258Pr-60
PTPRTdown-regulatesSMAD4activatesR-2357-0.6424258Pr-60
t(11;14)up-regulatesSMAD4activatesR-2357-0.6424258Pr-60
t(11;14)_cytogeneticup-regulatesSMAD4activatesR-2357-0.6424258Pr-60
PRDM1up-regulatesELF4repressesR-23430.76727116Pr-60
t(14;16)up-regulatesELF4repressesR-23430.76727116Pr-60
del1pup-regulatesELF4repressesR-23430.76727116Pr-60
BAI3down-regulatesETV2repressesR-15091.053837Pr-60
IRF4down-regulatesETV2repressesR-15091.053837Pr-60
t(11;14)down-regulatesETV2repressesR-15091.053837Pr-60
RNASeq_CCND3_Calldown-regulatesETV2repressesR-15091.053837Pr-60
RNASeq_FGFR3_Calldown-regulatesETV2repressesR-15091.053837Pr-60
t(4;14)down-regulatesETV2repressesR-15091.053837Pr-60
t(11;14)_cytogeneticdown-regulatesETV2repressesR-15091.053837Pr-60
RNASeq_MAFA_Calldown-regulatesNR2C2activatesR-1392-1.27136Pr-60
AHNAK2down-regulatesRFX3activatesR-16571.6851716Pr-60
CMYA5down-regulatesRFX3activatesR-16571.6851716Pr-60
DIS3up-regulatesRFX3activatesR-16571.6851716Pr-60
DSTdown-regulatesRFX3activatesR-16571.6851716Pr-60
FGFR3up-regulatesRFX3activatesR-16571.6851716Pr-60
IRF4up-regulatesRFX3activatesR-16571.6851716Pr-60
KIAA1244down-regulatesRFX3activatesR-16571.6851716Pr-60
KRASup-regulatesRFX3activatesR-16571.6851716Pr-60
MUC12down-regulatesRFX3activatesR-16571.6851716Pr-60
MYO10down-regulatesRFX3activatesR-16571.6851716Pr-60
PRKD2up-regulatesRFX3activatesR-16571.6851716Pr-60
t(11;14)up-regulatesRFX3activatesR-16571.6851716Pr-60
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-16571.6851716Pr-60
t(4;14)up-regulatesRFX3activatesR-16571.6851716Pr-60
t(11;14)_cytogeneticup-regulatesRFX3activatesR-16571.6851716Pr-60
t(14;16)_cytogeneticdown-regulatesRFX3activatesR-16571.6851716Pr-60
t(4;14)_cytogeneticup-regulatesRFX3activatesR-16571.6851716Pr-60
DIS3down-regulatesESRRArepressesR-27361.8254521Pr-60
FGFR3down-regulatesESRRArepressesR-27361.8254521Pr-60
IRF4down-regulatesESRRArepressesR-27361.8254521Pr-60
KIAA1244up-regulatesESRRArepressesR-27361.8254521Pr-60
MUC16up-regulatesESRRArepressesR-27361.8254521Pr-60
PRKD2down-regulatesESRRArepressesR-27361.8254521Pr-60
t(11;14)down-regulatesESRRArepressesR-27361.8254521Pr-60
RNASeq_CCND3_Calldown-regulatesESRRArepressesR-27361.8254521Pr-60
RNASeq_FGFR3_Calldown-regulatesESRRArepressesR-27361.8254521Pr-60
MYCup-regulatesESRRArepressesR-27361.8254521Pr-60
t(4;14)down-regulatesESRRArepressesR-27361.8254521Pr-60
t(11;14)_cytogeneticdown-regulatesESRRArepressesR-27361.8254521Pr-60
t(4;14)_cytogeneticdown-regulatesESRRArepressesR-27361.8254521Pr-60
CYLDup-regulatesNR3C1repressesR-31792.0662823Pr-60
DSCAML1up-regulatesNR3C1repressesR-31792.0662823Pr-60
IRF4down-regulatesNR3C1repressesR-31792.0662823Pr-60
KIAA1244up-regulatesNR3C1repressesR-31792.0662823Pr-60
MYO10up-regulatesNR3C1repressesR-31792.0662823Pr-60
NFKB2up-regulatesNR3C1repressesR-31792.0662823Pr-60
PRKD2down-regulatesNR3C1repressesR-31792.0662823Pr-60
t(11;14)down-regulatesNR3C1repressesR-31792.0662823Pr-60
RNASeq_MAFA_Callup-regulatesNR3C1repressesR-31792.0662823Pr-60
RNASeq_MAFB_Callup-regulatesNR3C1repressesR-31792.0662823Pr-60
t(14;16)up-regulatesNR3C1repressesR-31792.0662823Pr-60
SYNE2up-regulatesNR3C1repressesR-31792.0662823Pr-60
t(11;14)_cytogeneticdown-regulatesNR3C1repressesR-31792.0662823Pr-60
t(14;16)_cytogeneticup-regulatesNR3C1repressesR-31792.0662823Pr-60
t(4;14)_cytogeneticdown-regulatesNR3C1repressesR-31792.0662823Pr-60
AHNAK2up-regulatesARID3ArepressesR-13382.2322220Pr-60
CYLDup-regulatesARID3ArepressesR-13382.2322220Pr-60
DSTup-regulatesARID3ArepressesR-13382.2322220Pr-60
KRASdown-regulatesARID3ArepressesR-13382.2322220Pr-60
t(11;14)down-regulatesARID3ArepressesR-13382.2322220Pr-60
RNASeq_MAFA_Callup-regulatesARID3ArepressesR-13382.2322220Pr-60
t(14;16)_cytogeneticup-regulatesARID3ArepressesR-13382.2322220Pr-60
MACF1down-regulatesMEF2AactivatesR-1887-2.7074512Pr-60
NRASup-regulatesMEF2AactivatesR-1887-2.7074512Pr-60
SYNE1down-regulatesMEF2AactivatesR-1887-2.7074512Pr-60
del13up-regulatesMEF2AactivatesR-1887-2.7074512Pr-60
t(14;16)_cytogeneticdown-regulatesMEF2AactivatesR-1887-2.7074512Pr-60
DNAH5up-regulatesNFIArepressesR-354-2.90878Pr-60
NRASdown-regulatesNFIArepressesR-354-2.90878Pr-60
RNASeq_MAFA_Callup-regulatesNFIArepressesR-354-2.90878Pr-60
t(14;16)up-regulatesNFIArepressesR-354-2.90878Pr-60
TP53up-regulatesNFIArepressesR-354-2.90878Pr-60
t(14;16)_cytogeneticup-regulatesNFIArepressesR-354-2.90878Pr-60
t(11;14)down-regulatesARID3ArepressesR-13543.077986Pr-60
t(14;16)_cytogeneticup-regulatesARID3ArepressesR-13543.077986Pr-60

Regulons in program Pr-60

Regulon Cox Hazard Ratio # genes # causal flows
R-12-0.427939617
R-27530.4612651511
R-3140.46282166
R-24330.53714672
R-14110.58467149
R-2357-0.64242587
R-23430.767271163
R-15091.0538377
R-1392-1.271361
R-16571.685171617
R-27361.825452113
R-31792.066282315
R-13382.23222207
R-1887-2.70745125
R-354-2.908786
R-13543.0779862

Genes in program Pr-60

EnsEMBL IdEntrez IdPreferred
ENSG00000180209 29895MYLPF
ENSG00000180871 3579CXCR2
ENSG00000180900 23513SCRIB
ENSG00000181852 10193RNF41
ENSG00000182676 116729PPP1R27
ENSG00000183615 84734FAM167B
ENSG00000185187 59307SIGIRR
ENSG00000188976 26155NOC2L
ENSG00000197705 57565KLHL14
ENSG00000211450 280636SELENOH
ENSG00000214530 10809STARD10
ENSG00000239697 8742TNFSF12
ENSG00000250722 6414SELENOP

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions