Regulator – Multiple Myeloma Network Portal

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

VDR - vitamin D receptor

Uniprot Browser

Entrez ID	EnsEMBL ID	Preferred Name	Uniprot ID
7421	ENSG00000111424	VDR	P11473

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: VDR

Mutation	Regulator	Role	Regulon	Cox Hazard Ratio	Transcriptional Program
AHNAK2	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
DIS3	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
FAM46C	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
MACF1	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
RNASeq_FGFR3_Call	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
t(14;16)	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
t(4;14)	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
TRIO	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
amp1q	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
del13	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
t(4;14)_cytogenetic	VDR	represses	R-1228	1.0371	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
AHNAK2	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
BRAF	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
DIS3	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
t(11;14)	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
RNASeq_CCND2_Call	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
t(14;16)	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
t(11;14)_cytogenetic	VDR	activates	R-1229	-3.57357	Pr-115 Genes (0) Regulons (7) R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566
DIS3	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
DST	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
FAT3	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
IRF4	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
MACF1	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
MAX	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
PRKD2	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
RNASeq_FGFR3_Call	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
t(14;16)	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
t(4;14)	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
amp1q	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
t(4;14)_cytogenetic	VDR	represses	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
AHNAK2	VDR	activates	R-1230	-6.13961	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
DST	VDR	activates	R-1230	-6.13961	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
t(4;14)	VDR	activates	R-1230	-6.13961	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
amp1q	VDR	activates	R-1230	-6.13961	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230

VDR - vitamin D receptor

Causal Mechanistic Flows for Regulator: VDR

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Regulator Causal Mechanistic Flow Network