Program

Causal Mechanistic Flows with regulons in program Pr-138

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesRFX3repressesR-16660.1285319Pr-138
DIS3up-regulatesRFX3repressesR-16660.1285319Pr-138
DSTdown-regulatesRFX3repressesR-16660.1285319Pr-138
MAXdown-regulatesRFX3repressesR-16660.1285319Pr-138
PRKD2up-regulatesRFX3repressesR-16660.1285319Pr-138
t(11;14)up-regulatesRFX3repressesR-16660.1285319Pr-138
TRAF3down-regulatesRFX3repressesR-16660.1285319Pr-138
t(11;14)_cytogeneticup-regulatesRFX3repressesR-16660.1285319Pr-138
t(14;16)_cytogeneticdown-regulatesRFX3repressesR-16660.1285319Pr-138
DNAH10up-regulatesELF1repressesR-29810.16762417Pr-138
PRDM1up-regulatesELF1repressesR-29810.16762417Pr-138
t(11;14)up-regulatesELF1repressesR-29810.16762417Pr-138
TRAF3down-regulatesELF1repressesR-29810.16762417Pr-138
t(11;14)_cytogeneticup-regulatesELF1repressesR-29810.16762417Pr-138
DIS3up-regulatesRFX1activatesR-25670.3695959Pr-138
t(11;14)up-regulatesRFX1activatesR-25670.3695959Pr-138
t(11;14)_cytogeneticup-regulatesRFX1activatesR-25670.3695959Pr-138
MXRA5down-regulatesJUNactivatesR-11770.5080921Pr-138
t(11;14)up-regulatesJUNactivatesR-11770.5080921Pr-138
MYCdown-regulatesJUNactivatesR-11770.5080921Pr-138
TP53down-regulatesJUNactivatesR-11770.5080921Pr-138
t(11;14)_cytogeneticup-regulatesJUNactivatesR-11770.5080921Pr-138
LTBup-regulatesENSG00000143995activatesR-133-0.604496Pr-138
PRKD2up-regulatesENSG00000143995activatesR-133-0.604496Pr-138
RNASeq_FGFR3_Callup-regulatesENSG00000143995activatesR-133-0.604496Pr-138
RNASeq_MAFA_Calldown-regulatesENSG00000143995activatesR-133-0.604496Pr-138
t(4;14)up-regulatesENSG00000143995activatesR-133-0.604496Pr-138
t(4;14)_cytogeneticup-regulatesENSG00000143995activatesR-133-0.604496Pr-138
FAT3up-regulatesZNF691activatesR-30111.096397Pr-138
MAXup-regulatesZNF691activatesR-30111.096397Pr-138
RNASeq_CCND2_Callup-regulatesZNF691activatesR-30111.096397Pr-138
MYO10down-regulatesBACH1repressesR-472-1.401189Pr-138
t(11;14)up-regulatesBACH1repressesR-472-1.401189Pr-138
t(11;14)_cytogeneticup-regulatesBACH1repressesR-472-1.401189Pr-138
NRASdown-regulatesETS1repressesR-111.985736Pr-138
RNASeq_CCND2_Calldown-regulatesETS1repressesR-111.985736Pr-138
t(14;16)up-regulatesETS1repressesR-111.985736Pr-138
MYCdown-regulatesETS1repressesR-111.985736Pr-138
AHNAK2down-regulatesRARArepressesR-1692.421259Pr-138
DNAH5down-regulatesRARArepressesR-1692.421259Pr-138
MAXdown-regulatesRARArepressesR-1692.421259Pr-138
PCDH10down-regulatesRARArepressesR-1692.421259Pr-138
t(11;14)up-regulatesRARArepressesR-1692.421259Pr-138
SYNE1down-regulatesRARArepressesR-1692.421259Pr-138
TP53down-regulatesRARArepressesR-1692.421259Pr-138
del17pdown-regulatesRARArepressesR-1692.421259Pr-138
t(14;16)_cytogeneticdown-regulatesRARArepressesR-1692.421259Pr-138
AHNAK2down-regulatesRORArepressesR-22713.117388Pr-138
AHNAK2down-regulatesRFX3repressesR-16683.607058Pr-138
CMYA5down-regulatesRFX3repressesR-16683.607058Pr-138
DNAH5down-regulatesRFX3repressesR-16683.607058Pr-138
MAXdown-regulatesRFX3repressesR-16683.607058Pr-138
AHNAK2down-regulatesHBP1repressesR-18423.8568Pr-138
DNAH5down-regulatesHBP1repressesR-18423.8568Pr-138
FAT3down-regulatesHBP1repressesR-18423.8568Pr-138

Regulons in program Pr-138

Regulon Cox Hazard Ratio # genes # causal flows
R-16660.12853199
R-29810.167624175
R-25670.36959593
R-11770.50809215
R-133-0.6044966
R-30111.0963973
R-472-1.4011893
R-111.9857364
R-1692.4212599
R-22713.1173881
R-16683.6070584
R-18423.85683

Genes in program Pr-138

EnsEMBL IdEntrez IdPreferred
ENSG00000176438 161176SYNE3
ENSG00000176986 9632SEC24C
ENSG00000179314 23302WSCD1
ENSG00000181467 5912RAP2B
ENSG00000182950 161753ODF3L1
ENSG00000196189 64218SEMA4A
ENSG00000198689 10479SLC9A6
ENSG00000229474 197135PATL2
ENSG00000273045 150590C2orf15

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions