Program

Causal Mechanistic Flows with regulons in program Pr-132

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)up-regulatesDR1activatesR-440.4518636Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticup-regulatesDR1activatesR-440.4518636Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

DNAH10down-regulatesNR2F6repressesR-13781.480439Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

HUWE1down-regulatesNR2F6repressesR-13781.480439Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)down-regulatesNR2F6repressesR-13781.480439Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticdown-regulatesNR2F6repressesR-13781.480439Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

BRAFup-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

CACNA1Hdown-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

COL6A5down-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

IRF4up-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

KRASup-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

NFKB2down-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)up-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

RNASeq_CCND2_Callup-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticup-regulatesZNF219activatesR-22192.183866Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

NRASdown-regulatesARID3ArepressesR-13522.696417Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

OBSCNup-regulatesARID3ArepressesR-13522.696417Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)down-regulatesARID3ArepressesR-13522.696417Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(14;16)_cytogeneticup-regulatesARID3ArepressesR-13522.696417Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

DNAH10up-regulatesRUNX3activatesR-8982.740948Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

KRASup-regulatesRUNX3activatesR-8982.740948Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)up-regulatesRUNX3activatesR-8982.740948Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TP53up-regulatesRUNX3activatesR-8982.740948Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticup-regulatesRUNX3activatesR-8982.740948Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

DIS3up-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

FGFR3up-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

MAXup-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

MUC16down-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

PRKD2up-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

RNASeq_FGFR3_Callup-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(4;14)up-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

ROBO1down-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

del13up-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(4;14)_cytogeneticup-regulatesKLF4activatesR-27562.8963510Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

DNAH10up-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

KRASup-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)up-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TP53up-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TRAF3down-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticup-regulatesIRF1activatesR-1973.0515615Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

Regulons in program Pr-132

Regulon Cox Hazard Ratio # genes # causal flows
R-440.45186362
R-13781.4804394
R-22192.1838669
R-13522.6964174
R-8982.7409485
R-27562.896351010
R-1973.05156156

Genes in program Pr-132

EnsEMBL IdEntrez IdPreferred
ENSG00000180720 1132CHRM4
ENSG00000198909 4215MAP3K3
ENSG00000248098 593BCKDHA

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions