Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

E2F8 - E2F transcription factor 8

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
79733 ENSG00000129173 E2F8 A0AVK6

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: E2F8

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2E2F8activatesR-16294.14363Pr-136
FAT3E2F8activatesR-16294.14363Pr-136
MACF1E2F8activatesR-16294.14363Pr-136
MAXE2F8activatesR-16294.14363Pr-136
t(11;14)E2F8activatesR-16294.14363Pr-136
t(14;16)E2F8activatesR-16294.14363Pr-136
TP53E2F8activatesR-16294.14363Pr-136
ZNF462E2F8activatesR-16294.14363Pr-136
t(14;16)_cytogeneticE2F8activatesR-16294.14363Pr-136
AHNAK2E2F8activatesR-16268.62493Pr-68
CMYA5E2F8activatesR-16268.62493Pr-68
DMDE2F8activatesR-16268.62493Pr-68
DNAH10E2F8activatesR-16268.62493Pr-68
DNAH5E2F8activatesR-16268.62493Pr-68
FAT3E2F8activatesR-16268.62493Pr-68
HIST1H1EE2F8activatesR-16268.62493Pr-68
MACF1E2F8activatesR-16268.62493Pr-68
MAXE2F8activatesR-16268.62493Pr-68
MXRA5E2F8activatesR-16268.62493Pr-68
PCDH15E2F8activatesR-16268.62493Pr-68
PKHD1L1E2F8activatesR-16268.62493Pr-68
t(11;14)E2F8activatesR-16268.62493Pr-68
t(14;16)E2F8activatesR-16268.62493Pr-68
MYCE2F8activatesR-16268.62493Pr-68
TP53E2F8activatesR-16268.62493Pr-68
TTNE2F8activatesR-16268.62493Pr-68
ZNF208E2F8activatesR-16268.62493Pr-68
ZNF462E2F8activatesR-16268.62493Pr-68
del17E2F8activatesR-16268.62493Pr-68
del17pE2F8activatesR-16268.62493Pr-68
del1pE2F8activatesR-16268.62493Pr-68
t(14;16)_cytogeneticE2F8activatesR-16268.62493Pr-68
FAT3E2F8activatesR-16288.73321Pr-71
MAXE2F8activatesR-16288.73321Pr-71
t(11;14)E2F8activatesR-16288.73321Pr-71
t(14;16)E2F8activatesR-16288.73321Pr-71
TP53E2F8activatesR-16288.73321Pr-71
ZNF208E2F8activatesR-16288.73321Pr-71
AHNAK2E2F8activatesR-16279.26408Pr-68
CMYA5E2F8activatesR-16279.26408Pr-68
DMDE2F8activatesR-16279.26408Pr-68
DNAH10E2F8activatesR-16279.26408Pr-68
DNAH5E2F8activatesR-16279.26408Pr-68
FAT3E2F8activatesR-16279.26408Pr-68
HIST1H1EE2F8activatesR-16279.26408Pr-68
MACF1E2F8activatesR-16279.26408Pr-68
MAXE2F8activatesR-16279.26408Pr-68
MXRA5E2F8activatesR-16279.26408Pr-68
PCDH15E2F8activatesR-16279.26408Pr-68
t(11;14)E2F8activatesR-16279.26408Pr-68
t(14;16)E2F8activatesR-16279.26408Pr-68
MYCE2F8activatesR-16279.26408Pr-68
TP53E2F8activatesR-16279.26408Pr-68
TTNE2F8activatesR-16279.26408Pr-68
ZNF208E2F8activatesR-16279.26408Pr-68
ZNF462E2F8activatesR-16279.26408Pr-68
del17E2F8activatesR-16279.26408Pr-68
del17pE2F8activatesR-16279.26408Pr-68
del1pE2F8activatesR-16279.26408Pr-68
t(14;16)_cytogeneticE2F8activatesR-16279.26408Pr-68

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.