Program

Causal Mechanistic Flows with regulons in program Pr-61

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
IRF4down-regulatesPLAG1repressesR-1530-2.053567Pr-61
t(11;14)down-regulatesPLAG1repressesR-1530-2.053567Pr-61
t(11;14)_cytogeneticdown-regulatesPLAG1repressesR-1530-2.053567Pr-61
AHNAK2up-regulatesE2F1repressesR-2176-2.174227Pr-61
CMYA5up-regulatesE2F1repressesR-2176-2.174227Pr-61
MACF1up-regulatesE2F1repressesR-2176-2.174227Pr-61
PKHD1L1up-regulatesE2F1repressesR-2176-2.174227Pr-61
t(14;16)up-regulatesE2F1repressesR-2176-2.174227Pr-61
TTNup-regulatesE2F1repressesR-2176-2.174227Pr-61
t(14;16)_cytogeneticup-regulatesE2F1repressesR-2176-2.174227Pr-61
CMYA5down-regulatesRARAactivatesR-151-2.6314219Pr-61
t(11;14)up-regulatesRARAactivatesR-151-2.6314219Pr-61
TP53down-regulatesRARAactivatesR-151-2.6314219Pr-61
del13up-regulatesRARAactivatesR-151-2.6314219Pr-61
del17down-regulatesRARAactivatesR-151-2.6314219Pr-61
t(11;14)_cytogeneticup-regulatesRARAactivatesR-151-2.6314219Pr-61
t(14;16)up-regulatesELK1repressesR-637-3.0721316Pr-61
amp1qup-regulatesELK1repressesR-637-3.0721316Pr-61
del13up-regulatesELK1repressesR-637-3.0721316Pr-61
AHNAK2down-regulatesRARAactivatesR-153-3.194418Pr-61
CMYA5down-regulatesRARAactivatesR-153-3.194418Pr-61
DNAH5down-regulatesRARAactivatesR-153-3.194418Pr-61
IRF4up-regulatesRARAactivatesR-153-3.194418Pr-61
NEBdown-regulatesRARAactivatesR-153-3.194418Pr-61
t(11;14)up-regulatesRARAactivatesR-153-3.194418Pr-61
SYNE1down-regulatesRARAactivatesR-153-3.194418Pr-61
TACC2down-regulatesRARAactivatesR-153-3.194418Pr-61
t(11;14)_cytogeneticup-regulatesRARAactivatesR-153-3.194418Pr-61
FGFR3down-regulatesEGR1activatesR-2896-3.2025221Pr-61
MAXdown-regulatesEGR1activatesR-2896-3.2025221Pr-61
RNASeq_FGFR3_Calldown-regulatesEGR1activatesR-2896-3.2025221Pr-61
t(4;14)down-regulatesEGR1activatesR-2896-3.2025221Pr-61
CMYA5up-regulatesZBTB6repressesR-612-3.423896Pr-61
FAM46Cup-regulatesZBTB6repressesR-612-3.423896Pr-61
t(11;14)down-regulatesZBTB6repressesR-612-3.423896Pr-61
RNASeq_CCND3_Calldown-regulatesZBTB6repressesR-612-3.423896Pr-61
MYCup-regulatesZBTB6repressesR-612-3.423896Pr-61
t(11;14)_cytogeneticdown-regulatesZBTB6repressesR-612-3.423896Pr-61
FGFR3down-regulatesLMO2activatesR-909-3.887498Pr-61
LRP1Bdown-regulatesLMO2activatesR-909-3.887498Pr-61
MUC12down-regulatesLMO2activatesR-909-3.887498Pr-61
PCLOdown-regulatesLMO2activatesR-909-3.887498Pr-61
PKHD1L1down-regulatesLMO2activatesR-909-3.887498Pr-61
t(11;14)up-regulatesLMO2activatesR-909-3.887498Pr-61
RNASeq_FGFR3_Calldown-regulatesLMO2activatesR-909-3.887498Pr-61
t(14;16)down-regulatesLMO2activatesR-909-3.887498Pr-61
MYCdown-regulatesLMO2activatesR-909-3.887498Pr-61
t(4;14)down-regulatesLMO2activatesR-909-3.887498Pr-61
amp1qdown-regulatesLMO2activatesR-909-3.887498Pr-61
CMYA5down-regulatesPAX5activatesR-2375-4.0433511Pr-61
FGFR3down-regulatesPAX5activatesR-2375-4.0433511Pr-61
FLGdown-regulatesPAX5activatesR-2375-4.0433511Pr-61
IRF4up-regulatesPAX5activatesR-2375-4.0433511Pr-61
KIAA1109down-regulatesPAX5activatesR-2375-4.0433511Pr-61
MUC12down-regulatesPAX5activatesR-2375-4.0433511Pr-61
PCLOdown-regulatesPAX5activatesR-2375-4.0433511Pr-61
t(11;14)up-regulatesPAX5activatesR-2375-4.0433511Pr-61
RNASeq_FGFR3_Calldown-regulatesPAX5activatesR-2375-4.0433511Pr-61
t(14;16)down-regulatesPAX5activatesR-2375-4.0433511Pr-61
t(4;14)down-regulatesPAX5activatesR-2375-4.0433511Pr-61
amp1qdown-regulatesPAX5activatesR-2375-4.0433511Pr-61
del13down-regulatesPAX5activatesR-2375-4.0433511Pr-61
t(11;14)_cytogeneticup-regulatesPAX5activatesR-2375-4.0433511Pr-61
t(4;14)_cytogeneticdown-regulatesPAX5activatesR-2375-4.0433511Pr-61
DCHS1down-regulatesFOXO1activatesR-1414-4.1045913Pr-61
FAT3down-regulatesFOXO1activatesR-1414-4.1045913Pr-61
t(11;14)up-regulatesFOXO1activatesR-1414-4.1045913Pr-61
RNASeq_MAFB_Calldown-regulatesFOXO1activatesR-1414-4.1045913Pr-61
SVILdown-regulatesFOXO1activatesR-1414-4.1045913Pr-61
t(14;16)_cytogeneticdown-regulatesFOXO1activatesR-1414-4.1045913Pr-61
AHNAK2down-regulatesELF1activatesR-2980-4.3920318Pr-61
DNAH10up-regulatesELF1activatesR-2980-4.3920318Pr-61
DSTdown-regulatesELF1activatesR-2980-4.3920318Pr-61
t(11;14)up-regulatesELF1activatesR-2980-4.3920318Pr-61
t(11;14)_cytogeneticup-regulatesELF1activatesR-2980-4.3920318Pr-61
RNASeq_MAFA_Callup-regulatesELK1repressesR-653-4.708536Pr-61
t(14;16)up-regulatesELK1repressesR-653-4.708536Pr-61
amp1qup-regulatesELK1repressesR-653-4.708536Pr-61
t(11;14)down-regulatesPLAG1repressesR-1529-5.514797Pr-61
t(11;14)_cytogeneticdown-regulatesPLAG1repressesR-1529-5.514797Pr-61

Regulons in program Pr-61

Regulon Cox Hazard Ratio # genes # causal flows
R-1530-2.0535673
R-2176-2.1742277
R-151-2.63142196
R-637-3.07213163
R-153-3.1944189
R-2896-3.20252214
R-612-3.4238966
R-909-3.88749811
R-2375-4.043351115
R-1414-4.10459136
R-2980-4.39203185
R-653-4.7085363
R-1529-5.5147972

Genes in program Pr-61

EnsEMBL IdEntrez IdPreferred
ENSG00000237541 3117HLA-DQA1
ENSG00000244486 91179SCARF2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions