Program

Causal Mechanistic Flows with regulons in program Pr-15

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(14;16)up-regulatesPRDM1activatesR-2088-0.6278387Pr-15
amp1qup-regulatesPRDM1activatesR-2088-0.6278387Pr-15
del13up-regulatesPRDM1activatesR-2088-0.6278387Pr-15
t(11;14)down-regulatesKLF13activatesR-2040-0.74158411Pr-15
ROBO1up-regulatesKLF13activatesR-2040-0.74158411Pr-15
t(11;14)_cytogeneticdown-regulatesKLF13activatesR-2040-0.74158411Pr-15
DNAH5down-regulatesNFATC1activatesR-2207-1.003856Pr-15
FAT3down-regulatesNFATC1activatesR-2207-1.003856Pr-15
FBN2down-regulatesNFATC1activatesR-2207-1.003856Pr-15
LRP2down-regulatesNFATC1activatesR-2207-1.003856Pr-15
MAXdown-regulatesNFATC1activatesR-2207-1.003856Pr-15
NRASdown-regulatesNFATC1activatesR-2207-1.003856Pr-15
PKHD1L1down-regulatesNFATC1activatesR-2207-1.003856Pr-15
PRKD2up-regulatesNFATC1activatesR-2207-1.003856Pr-15
t(11;14)up-regulatesNFATC1activatesR-2207-1.003856Pr-15
RNASeq_CCND2_Calldown-regulatesNFATC1activatesR-2207-1.003856Pr-15
RNASeq_CCND3_Callup-regulatesNFATC1activatesR-2207-1.003856Pr-15
RNASeq_MAFA_Calldown-regulatesNFATC1activatesR-2207-1.003856Pr-15
ROBO1up-regulatesNFATC1activatesR-2207-1.003856Pr-15
del13up-regulatesNFATC1activatesR-2207-1.003856Pr-15
t(11;14)_cytogeneticup-regulatesNFATC1activatesR-2207-1.003856Pr-15
NRASdown-regulatesKLF7activatesR-282-1.1609411Pr-15
t(11;14)down-regulatesKLF7activatesR-282-1.1609411Pr-15
t(14;16)up-regulatesKLF7activatesR-282-1.1609411Pr-15
ROBO1up-regulatesKLF7activatesR-282-1.1609411Pr-15
TRAF3up-regulatesKLF7activatesR-282-1.1609411Pr-15
amp1qup-regulatesKLF7activatesR-282-1.1609411Pr-15
del13up-regulatesKLF7activatesR-282-1.1609411Pr-15
t(11;14)_cytogeneticdown-regulatesKLF7activatesR-282-1.1609411Pr-15
t(14;16)up-regulatesZEB1activatesR-2251-1.179337Pr-15
amp1qup-regulatesZEB1activatesR-2251-1.179337Pr-15
del13up-regulatesZEB1activatesR-2251-1.179337Pr-15
del1pup-regulatesZEB1activatesR-2251-1.179337Pr-15
FAT3up-regulatesE2F2repressesR-2946-1.274347Pr-15
TP53up-regulatesE2F2repressesR-2946-1.274347Pr-15
MAXdown-regulatesNFKB1activatesR-1593-1.407496Pr-15
RNASeq_CCND2_Calldown-regulatesNFKB1activatesR-1593-1.407496Pr-15
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1593-1.407496Pr-15
t(4;14)down-regulatesNFKB1activatesR-1593-1.407496Pr-15
t(4;14)_cytogeneticdown-regulatesNFKB1activatesR-1593-1.407496Pr-15
MAXdown-regulatesESRRAactivatesR-2737-1.4242419Pr-15
t(11;14)down-regulatesESRRAactivatesR-2737-1.4242419Pr-15
RNASeq_FGFR3_Calldown-regulatesESRRAactivatesR-2737-1.4242419Pr-15
t(4;14)down-regulatesESRRAactivatesR-2737-1.4242419Pr-15
ROBO1up-regulatesESRRAactivatesR-2737-1.4242419Pr-15
t(11;14)_cytogeneticdown-regulatesESRRAactivatesR-2737-1.4242419Pr-15
t(4;14)_cytogeneticdown-regulatesESRRAactivatesR-2737-1.4242419Pr-15
t(11;14)up-regulatesNFYArepressesR-1470-1.5631216Pr-15
RNASeq_FGFR3_Callup-regulatesNFYArepressesR-1470-1.5631216Pr-15
FAT3down-regulatesHBP1activatesR-1848-1.731826Pr-15
amp1qup-regulatesHBP1activatesR-1848-1.731826Pr-15
del13up-regulatesHBP1activatesR-1848-1.731826Pr-15
TP53up-regulatesZBTB3repressesR-1263-1.7428813Pr-15
del13down-regulatesZBTB3repressesR-1263-1.7428813Pr-15
DIS3up-regulatesNFYCrepressesR-297-2.113348Pr-15
FGFR3up-regulatesNFYCrepressesR-297-2.113348Pr-15
t(11;14)up-regulatesNFYCrepressesR-297-2.113348Pr-15
RNASeq_FGFR3_Callup-regulatesNFYCrepressesR-297-2.113348Pr-15
t(4;14)up-regulatesNFYCrepressesR-297-2.113348Pr-15
ROBO1down-regulatesNFYCrepressesR-297-2.113348Pr-15
amp1qdown-regulatesNFYCrepressesR-297-2.113348Pr-15
del1pdown-regulatesNFYCrepressesR-297-2.113348Pr-15
t(11;14)_cytogeneticup-regulatesNFYCrepressesR-297-2.113348Pr-15
t(4;14)_cytogeneticup-regulatesNFYCrepressesR-297-2.113348Pr-15
amp1qup-regulatesIKZF1activatesR-989-2.1320417Pr-15
del13up-regulatesIKZF1activatesR-989-2.1320417Pr-15
CYLDdown-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
FGFR3up-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
MAXup-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
PRKD2up-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
RNASeq_FGFR3_Callup-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
RNASeq_MAFA_Calldown-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
t(14;16)down-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
t(4;14)up-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
ROBO1down-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
t(4;14)_cytogeneticup-regulatesENSG00000136574repressesR-36-2.2479115Pr-15
DIS3down-regulatesSRFactivatesR-1782-2.5290832Pr-15
FAT3down-regulatesSRFactivatesR-1782-2.5290832Pr-15
IRF4down-regulatesSRFactivatesR-1782-2.5290832Pr-15
PRKD2down-regulatesSRFactivatesR-1782-2.5290832Pr-15
t(11;14)down-regulatesSRFactivatesR-1782-2.5290832Pr-15
RNASeq_FGFR3_Calldown-regulatesSRFactivatesR-1782-2.5290832Pr-15
t(4;14)down-regulatesSRFactivatesR-1782-2.5290832Pr-15
t(14;16)up-regulatesFOXJ2activatesR-1427-2.6166931Pr-15
amp1qup-regulatesFOXJ2activatesR-1427-2.6166931Pr-15
del13up-regulatesFOXJ2activatesR-1427-2.6166931Pr-15
CYLDdown-regulatesTCF3repressesR-2049-2.7211238Pr-15
MAXup-regulatesTCF3repressesR-2049-2.7211238Pr-15
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-2049-2.7211238Pr-15
t(14;16)down-regulatesTCF3repressesR-2049-2.7211238Pr-15
ZNF208up-regulatesTCF3repressesR-2049-2.7211238Pr-15
t(11;14)up-regulatesFOSrepressesR-2191-2.781318Pr-15
RNASeq_FGFR3_Callup-regulatesFOSrepressesR-2191-2.781318Pr-15
t(14;16)down-regulatesFOSrepressesR-2191-2.781318Pr-15
ROBO1down-regulatesFOSrepressesR-2191-2.781318Pr-15
amp1qdown-regulatesFOSrepressesR-2191-2.781318Pr-15
del13down-regulatesFOSrepressesR-2191-2.781318Pr-15
del1pdown-regulatesFOSrepressesR-2191-2.781318Pr-15
t(11;14)_cytogeneticup-regulatesFOSrepressesR-2191-2.781318Pr-15
FAT3down-regulatesRREB1activatesR-2288-3.1217219Pr-15
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2288-3.1217219Pr-15
t(4;14)down-regulatesRREB1activatesR-2288-3.1217219Pr-15
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2288-3.1217219Pr-15
ASXL3up-regulatesRARBrepressesR-1104-3.1269212Pr-15
FAT3up-regulatesRARBrepressesR-1104-3.1269212Pr-15
t(11;14)up-regulatesRARBrepressesR-1104-3.1269212Pr-15
del13down-regulatesRARBrepressesR-1104-3.1269212Pr-15
MAXdown-regulatesRARAactivatesR-149-3.3618420Pr-15
del13up-regulatesRARAactivatesR-149-3.3618420Pr-15
ATMup-regulatesSMAD3activatesR-2959-3.4732315Pr-15
CACNA1Hup-regulatesSMAD3activatesR-2959-3.4732315Pr-15
CSMD1up-regulatesSMAD3activatesR-2959-3.4732315Pr-15
NRASdown-regulatesSMAD3activatesR-2959-3.4732315Pr-15
RNASeq_MAFA_Callup-regulatesSMAD3activatesR-2959-3.4732315Pr-15
t(14;16)up-regulatesSMAD3activatesR-2959-3.4732315Pr-15
amp1qup-regulatesSMAD3activatesR-2959-3.4732315Pr-15
del1pup-regulatesSMAD3activatesR-2959-3.4732315Pr-15

Regulons in program Pr-15

Regulon Cox Hazard Ratio # genes # causal flows
R-2088-0.62783873
R-2040-0.741584113
R-2207-1.00385615
R-282-1.16094118
R-2251-1.1793374
R-2946-1.2743472
R-1593-1.4074965
R-2737-1.42424197
R-1470-1.56312162
R-1848-1.7318263
R-1263-1.74288132
R-297-2.11334810
R-989-2.13204172
R-36-2.247911510
R-1782-2.52908327
R-1427-2.61669313
R-2049-2.72112385
R-2191-2.7813188
R-2288-3.12172194
R-1104-3.12692124
R-149-3.36184202
R-2959-3.47323158

Genes in program Pr-15

EnsEMBL IdEntrez IdPreferred
ENSG00000183347
ENSG00000184863 155435RBM33
ENSG00000188282 285180RUFY4
ENSG00000196754
ENSG00000196950 57181SLC39A10
ENSG00000197713 6120RPE
ENSG00000198715 112770GLMP
ENSG00000198736 51734MSRB1
ENSG00000204217 659BMPR2
ENSG00000213445 6494SIPA1
ENSG00000213585 7416VDAC1
ENSG00000242372 3692EIF6
ENSG00000243244 11037STON1
ENSG00000253729 5591PRKDC

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions