Program

Causal Mechanistic Flows with regulons in program Pr-22

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesELF4activatesR-2350-0.79444311Pr-22
FGFR3up-regulatesELF4activatesR-2350-0.79444311Pr-22
PRKD2up-regulatesELF4activatesR-2350-0.79444311Pr-22
RNASeq_FGFR3_Callup-regulatesELF4activatesR-2350-0.79444311Pr-22
CMYA5down-regulatesELF3activatesR-2151-0.79444311Pr-22
TP53down-regulatesELF3activatesR-2151-0.79444311Pr-22
amp1qup-regulatesELF3activatesR-2151-0.79444311Pr-22
FGFR3up-regulatesSOX4activatesR-2186-0.805878Pr-22
NRASdown-regulatesSOX4activatesR-2186-0.805878Pr-22
PRKD2up-regulatesSOX4activatesR-2186-0.805878Pr-22
RNASeq_FGFR3_Callup-regulatesSOX4activatesR-2186-0.805878Pr-22
RNASeq_MAFB_Calldown-regulatesSOX4activatesR-2186-0.805878Pr-22
t(4;14)up-regulatesSOX4activatesR-2186-0.805878Pr-22
RYR1down-regulatesSOX4activatesR-2186-0.805878Pr-22
t(4;14)_cytogeneticup-regulatesSOX4activatesR-2186-0.805878Pr-22
KDM3Bup-regulatesZNF143repressesR-2316-1.28458Pr-22
RNASeq_MAFA_Callup-regulatesZNF143repressesR-2316-1.28458Pr-22
AHNAK2down-regulatesMEF2AactivatesR-1888-1.3848612Pr-22
MYO10down-regulatesMEF2AactivatesR-1888-1.3848612Pr-22
PTPRDdown-regulatesMEF2AactivatesR-1888-1.3848612Pr-22
RNASeq_MAFB_Calldown-regulatesMEF2AactivatesR-1888-1.3848612Pr-22
SYNE1down-regulatesMEF2AactivatesR-1888-1.3848612Pr-22
FGFR3up-regulatesMEF2DactivatesR-876-1.509777Pr-22
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-876-1.509777Pr-22
t(4;14)up-regulatesMEF2DactivatesR-876-1.509777Pr-22
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-876-1.509777Pr-22
CMYA5down-regulatesHLXactivatesR-2765-1.894416Pr-22
KDM3Bdown-regulatesHLXactivatesR-2765-1.894416Pr-22
PRKD2up-regulatesHLXactivatesR-2765-1.894416Pr-22
RNASeq_FGFR3_Callup-regulatesHLXactivatesR-2765-1.894416Pr-22
t(4;14)up-regulatesHLXactivatesR-2765-1.894416Pr-22
t(4;14)_cytogeneticup-regulatesHLXactivatesR-2765-1.894416Pr-22
AHNAK2down-regulatesRFX3activatesR-1678-2.048246Pr-22
CMYA5down-regulatesRFX3activatesR-1678-2.048246Pr-22
MAXdown-regulatesRFX3activatesR-1678-2.048246Pr-22
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-1678-2.048246Pr-22
t(4;14)up-regulatesRFX3activatesR-1678-2.048246Pr-22
t(14;16)_cytogeneticdown-regulatesRFX3activatesR-1678-2.048246Pr-22
t(4;14)_cytogeneticup-regulatesRFX3activatesR-1678-2.048246Pr-22
PTPRDdown-regulatesENSG00000054598activatesR-1015-2.0867810Pr-22
t(14;16)_cytogeneticdown-regulatesENSG00000054598activatesR-1015-2.0867810Pr-22

Regulons in program Pr-22

Regulon Cox Hazard Ratio # genes # causal flows
R-2350-0.794443114
R-2151-0.794443113
R-2186-0.8058788
R-2316-1.284582
R-1888-1.38486125
R-876-1.5097774
R-2765-1.8944166
R-1678-2.0482467
R-1015-2.08678102

Genes in program Pr-22

EnsEMBL IdEntrez IdPreferred
ENSG00000185475 374395TMEM179B
ENSG00000185477 285513GPRIN3
ENSG00000185522 256329LMNTD2
ENSG00000197782 284323ZNF780A
ENSG00000198517 7975MAFK
ENSG00000203667 116228COX20
ENSG00000221829 2189FANCG
ENSG00000237440 100129842ZNF737
ENSG00000240344 53938PPIL3

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions