Program

Causal Mechanistic Flows with regulons in program Pr-19

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesHSF1activatesR-51-0.80365610Pr-19
DIS3down-regulatesHSF1activatesR-51-0.80365610Pr-19
FAM46Cup-regulatesHSF1activatesR-51-0.80365610Pr-19
MAGI1down-regulatesHSF1activatesR-51-0.80365610Pr-19
MAXdown-regulatesHSF1activatesR-51-0.80365610Pr-19
MYO10down-regulatesHSF1activatesR-51-0.80365610Pr-19
PTPRDdown-regulatesHSF1activatesR-51-0.80365610Pr-19
RNASeq_CCND2_Calldown-regulatesHSF1activatesR-51-0.80365610Pr-19
RNASeq_FGFR3_Calldown-regulatesHSF1activatesR-51-0.80365610Pr-19
RNASeq_MAFB_Calldown-regulatesHSF1activatesR-51-0.80365610Pr-19
TACC2down-regulatesHSF1activatesR-51-0.80365610Pr-19
FAM46Cdown-regulatesZNF740repressesR-392-1.257957Pr-19
AHNAK2down-regulatesFLI1activatesR-789-1.431379Pr-19
DIS3down-regulatesFLI1activatesR-789-1.431379Pr-19
FAM46Cup-regulatesFLI1activatesR-789-1.431379Pr-19
FAT3down-regulatesFLI1activatesR-789-1.431379Pr-19
FRAS1down-regulatesFLI1activatesR-789-1.431379Pr-19
MAXdown-regulatesFLI1activatesR-789-1.431379Pr-19
PTPRDdown-regulatesFLI1activatesR-789-1.431379Pr-19
t(11;14)down-regulatesFLI1activatesR-789-1.431379Pr-19
RNASeq_CCND2_Calldown-regulatesFLI1activatesR-789-1.431379Pr-19
TRAF3down-regulatesFLI1activatesR-789-1.431379Pr-19
t(11;14)_cytogeneticdown-regulatesFLI1activatesR-789-1.431379Pr-19
AHNAK2down-regulatesZNF281activatesR-2483-1.5682614Pr-19
FAT3down-regulatesZNF281activatesR-2483-1.5682614Pr-19
MACF1down-regulatesZNF281activatesR-2483-1.5682614Pr-19
PCDH10down-regulatesZNF281activatesR-2483-1.5682614Pr-19
PTPRDdown-regulatesZNF281activatesR-2483-1.5682614Pr-19
TACC2down-regulatesZNF281activatesR-2483-1.5682614Pr-19
MAXdown-regulatesETS1activatesR-2-1.5857915Pr-19
RNASeq_CCND2_Calldown-regulatesETS1activatesR-2-1.5857915Pr-19
RNASeq_FGFR3_Calldown-regulatesETS1activatesR-2-1.5857915Pr-19
t(4;14)down-regulatesETS1activatesR-2-1.5857915Pr-19
t(4;14)_cytogeneticdown-regulatesETS1activatesR-2-1.5857915Pr-19
AHNAK2down-regulatesEWSR1activatesR-2551-1.661713Pr-19
MACF1down-regulatesEWSR1activatesR-2551-1.661713Pr-19
PCDH10down-regulatesEWSR1activatesR-2551-1.661713Pr-19
RNASeq_MAFB_Calldown-regulatesEWSR1activatesR-2551-1.661713Pr-19
TACC2down-regulatesEWSR1activatesR-2551-1.661713Pr-19
AHNAK2up-regulatesMAZrepressesR-501-1.7717515Pr-19
DCHS1up-regulatesMAZrepressesR-501-1.7717515Pr-19
DIS3up-regulatesMAZrepressesR-501-1.7717515Pr-19
FAM46Cdown-regulatesMAZrepressesR-501-1.7717515Pr-19
FAT3up-regulatesMAZrepressesR-501-1.7717515Pr-19
RNASeq_FGFR3_Callup-regulatesMAZrepressesR-501-1.7717515Pr-19
t(4;14)up-regulatesMAZrepressesR-501-1.7717515Pr-19
TRAF3up-regulatesMAZrepressesR-501-1.7717515Pr-19
TRIOup-regulatesMAZrepressesR-501-1.7717515Pr-19
t(4;14)_cytogeneticup-regulatesMAZrepressesR-501-1.7717515Pr-19
AHNAK2down-regulatesSPDEFactivatesR-1967-2.269819Pr-19
CYLDup-regulatesSPDEFactivatesR-1967-2.269819Pr-19
IRF4down-regulatesSPDEFactivatesR-1967-2.269819Pr-19
MAGI1down-regulatesSPDEFactivatesR-1967-2.269819Pr-19
PTPRDdown-regulatesSPDEFactivatesR-1967-2.269819Pr-19
t(11;14)down-regulatesSPDEFactivatesR-1967-2.269819Pr-19
RNASeq_MAFB_Calldown-regulatesSPDEFactivatesR-1967-2.269819Pr-19
ZFHX3down-regulatesSPDEFactivatesR-1967-2.269819Pr-19
AHNAK2down-regulatesRFX3activatesR-1674-2.697247Pr-19
CMYA5down-regulatesRFX3activatesR-1674-2.697247Pr-19
DNAH5down-regulatesRFX3activatesR-1674-2.697247Pr-19
DSTdown-regulatesRFX3activatesR-1674-2.697247Pr-19
MAXdown-regulatesRFX3activatesR-1674-2.697247Pr-19
TRAF3down-regulatesRFX3activatesR-1674-2.697247Pr-19
t(14;16)_cytogeneticdown-regulatesRFX3activatesR-1674-2.697247Pr-19
CMYA5down-regulatesNFATC1activatesR-2202-2.72448Pr-19
CYLDup-regulatesNFATC1activatesR-2202-2.72448Pr-19
DNAH5down-regulatesNFATC1activatesR-2202-2.72448Pr-19
FAT3down-regulatesNFATC1activatesR-2202-2.72448Pr-19
MAXdown-regulatesNFATC1activatesR-2202-2.72448Pr-19
PKHD1L1down-regulatesNFATC1activatesR-2202-2.72448Pr-19
RNASeq_CCND2_Calldown-regulatesNFATC1activatesR-2202-2.72448Pr-19
MAXdown-regulatesENSG00000179348activatesR-1064-2.781267Pr-19
TRAF3down-regulatesENSG00000179348activatesR-1064-2.781267Pr-19
t(14;16)_cytogeneticdown-regulatesENSG00000179348activatesR-1064-2.781267Pr-19

Regulons in program Pr-19

Regulon Cox Hazard Ratio # genes # causal flows
R-51-0.8036561011
R-392-1.2579571
R-789-1.43137911
R-2483-1.56826146
R-2-1.58579155
R-2551-1.6617135
R-501-1.771751510
R-1967-2.2698198
R-1674-2.6972477
R-2202-2.724487
R-1064-2.7812673

Genes in program Pr-19

EnsEMBL IdEntrez IdPreferred
ENSG00000185519
ENSG00000197565 1288COL4A6
ENSG00000198756
ENSG00000204228 7923HSD17B8
ENSG00000204421
ENSG00000205560 1375CPT1B
ENSG00000213889 147699PPM1N
ENSG00000254087 4067LYN

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions