Program

Causal Mechanistic Flows with regulons in program Pr-69

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CYLDup-regulatesTRAF4activatesR-3040-2.512518Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_FGFR3_Calldown-regulatesTRAF4activatesR-3040-2.512518Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3down-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAXdown-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_CCND2_Calldown-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ZNF208down-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)_cytogeneticdown-regulatesNR3C1repressesR-31883.3435412Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DCHS1down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DIS3down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAM46Cup-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_FGFR3_Calldown-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_MAFB_Calldown-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)down-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)_cytogeneticdown-regulatesNFKB1repressesR-15813.6729714Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ABCA13down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

CMYA5down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DNAH5down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAGI1down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MYO10down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

PTPRDdown-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)up-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TACC2down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

del17down-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

del17pdown-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)_cytogeneticup-regulatesPOU2F1repressesR-884.322520Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

CMYA5down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DNAH5down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DSTdown-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAXdown-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MUC12down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MYO10down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)up-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TRAF3down-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)_cytogeneticup-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)_cytogeneticdown-regulatesRFX3repressesR-16654.5586610Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesERFrepressesR-3345.116587Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3down-regulatesERFrepressesR-3345.116587Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1down-regulatesERFrepressesR-3345.116587Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAXdown-regulatesERFrepressesR-3345.116587Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)_cytogeneticdown-regulatesERFrepressesR-3345.116587Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesETV6repressesR-7035.5451213Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DIS3down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAM46Cup-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FRAS1down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

IRF4down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAXdown-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_CCND2_Calldown-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TRAF3down-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(11;14)_cytogeneticdown-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)_cytogeneticdown-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)_cytogeneticdown-regulatesFLI1repressesR-7836.145914Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

AHNAK2up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DIS3up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

IRF4up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_MAFA_Callup-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SVILup-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TRAF3up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TTNup-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ZNF462up-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)_cytogeneticup-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)_cytogeneticup-regulatesSP1activatesR-27196.7327130Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Regulons in program Pr-69

Regulon Cox Hazard Ratio # genes # causal flows
R-3040-2.5125182
R-31883.34354126
R-15813.672971410
R-884.32252014
R-16654.558661011
R-3345.1165875
R-7035.54512131
R-7836.14591416
R-27196.732713013

Genes in program Pr-69

EnsEMBL IdEntrez IdPreferred
ENSG00000275746 51621KLF13

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions