Program

Causal Mechanistic Flows with regulons in program Pr-101

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)up-regulatesMAFGrepressesR-1496-0.9047596Pr-101
t(14;16)up-regulatesMAFGrepressesR-1496-0.9047596Pr-101
MYCdown-regulatesMAFGrepressesR-1496-0.9047596Pr-101
t(4;14)up-regulatesMAFGrepressesR-1496-0.9047596Pr-101
del13up-regulatesMAFGrepressesR-1496-0.9047596Pr-101
t(11;14)_cytogeneticup-regulatesMAFGrepressesR-1496-0.9047596Pr-101
t(4;14)_cytogeneticup-regulatesMAFGrepressesR-1496-0.9047596Pr-101
DMDdown-regulatesNFE2L2activatesR-1909-1.5354513Pr-101
amp1qdown-regulatesNFE2L2activatesR-1909-1.5354513Pr-101
del13down-regulatesNFE2L2activatesR-1909-1.5354513Pr-101
t(11;14)down-regulatesBDP1activatesR-840-2.214678Pr-101
t(11;14)_cytogeneticdown-regulatesBDP1activatesR-840-2.214678Pr-101
DIS3down-regulatesBARX2activatesR-292-2.431977Pr-101
FAM46Cup-regulatesBARX2activatesR-292-2.431977Pr-101
IRF4down-regulatesBARX2activatesR-292-2.431977Pr-101
MAXdown-regulatesBARX2activatesR-292-2.431977Pr-101
NRASup-regulatesBARX2activatesR-292-2.431977Pr-101
PRKD2down-regulatesBARX2activatesR-292-2.431977Pr-101
t(11;14)down-regulatesBARX2activatesR-292-2.431977Pr-101
RNASeq_FGFR3_Calldown-regulatesBARX2activatesR-292-2.431977Pr-101
t(14;16)down-regulatesBARX2activatesR-292-2.431977Pr-101
t(4;14)down-regulatesBARX2activatesR-292-2.431977Pr-101
TRAF3down-regulatesBARX2activatesR-292-2.431977Pr-101
TRIOdown-regulatesBARX2activatesR-292-2.431977Pr-101
t(4;14)_cytogeneticdown-regulatesBARX2activatesR-292-2.431977Pr-101
t(11;14)up-regulatesELF3repressesR-2138-2.5119629Pr-101
FAT3down-regulatesNR3C1activatesR-3196-2.613316Pr-101
IRF4down-regulatesNR3C1activatesR-3196-2.613316Pr-101
PRKD2down-regulatesNR3C1activatesR-3196-2.613316Pr-101
t(11;14)down-regulatesNR3C1activatesR-3196-2.613316Pr-101
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3196-2.613316Pr-101
t(4;14)_cytogeneticdown-regulatesNR3C1activatesR-3196-2.613316Pr-101
RNASeq_MAFA_Calldown-regulatesTRIM28activatesR-1505-2.681057Pr-101
IRF4down-regulatesNR3C1activatesR-3182-2.8390819Pr-101
MAXdown-regulatesNR3C1activatesR-3182-2.8390819Pr-101
PRKD2down-regulatesNR3C1activatesR-3182-2.8390819Pr-101
t(11;14)down-regulatesNR3C1activatesR-3182-2.8390819Pr-101
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3182-2.8390819Pr-101
t(4;14)_cytogeneticdown-regulatesNR3C1activatesR-3182-2.8390819Pr-101
ATMup-regulatesENSG00000175832repressesR-313-2.858779Pr-101
DIS3up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
DNAH10up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
FAM46Cdown-regulatesENSG00000175832repressesR-313-2.858779Pr-101
FRAS1up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
HUWE1up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
IRF4up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
MAXup-regulatesENSG00000175832repressesR-313-2.858779Pr-101
PRKD2up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
t(11;14)up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
RNASeq_FGFR3_Callup-regulatesENSG00000175832repressesR-313-2.858779Pr-101
t(14;16)up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
t(4;14)up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
SETD2up-regulatesENSG00000175832repressesR-313-2.858779Pr-101
t(11;14)_cytogeneticup-regulatesENSG00000175832repressesR-313-2.858779Pr-101
t(4;14)_cytogeneticup-regulatesENSG00000175832repressesR-313-2.858779Pr-101
DIS3down-regulatesERFactivatesR-330-2.9584713Pr-101
FAM46Cup-regulatesERFactivatesR-330-2.9584713Pr-101
FAT3down-regulatesERFactivatesR-330-2.9584713Pr-101
MAXdown-regulatesERFactivatesR-330-2.9584713Pr-101
NRASup-regulatesERFactivatesR-330-2.9584713Pr-101
RNASeq_FGFR3_Calldown-regulatesERFactivatesR-330-2.9584713Pr-101
RNASeq_MAFA_Calldown-regulatesERFactivatesR-330-2.9584713Pr-101
RNASeq_MAFB_Calldown-regulatesERFactivatesR-330-2.9584713Pr-101
t(4;14)down-regulatesERFactivatesR-330-2.9584713Pr-101
t(4;14)_cytogeneticdown-regulatesERFactivatesR-330-2.9584713Pr-101
t(11;14)up-regulatesETS2repressesR-1903-3.028398Pr-101
DIS3up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
FGFR3up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
IRF4up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
t(11;14)up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
RNASeq_MAFA_Callup-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
t(14;16)up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
t(4;14)up-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
t(11;14)_cytogeneticup-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
t(4;14)_cytogeneticup-regulatesSTAT5ArepressesR-2161-3.0719915Pr-101
DNAH10up-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
FGFR3up-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
NRASdown-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
RNASeq_FGFR3_Callup-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
RNASeq_MAFB_Callup-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
t(14;16)up-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
t(4;14)up-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
del13up-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
t(4;14)_cytogeneticup-regulatesSTAT5BrepressesR-2368-3.1600412Pr-101
FAT3down-regulatesRREB1activatesR-2292-3.4639416Pr-101
PRKD2down-regulatesRREB1activatesR-2292-3.4639416Pr-101
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2292-3.4639416Pr-101
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2292-3.4639416Pr-101
RNASeq_MAFB_Calldown-regulatesRREB1activatesR-2292-3.4639416Pr-101
t(4;14)down-regulatesRREB1activatesR-2292-3.4639416Pr-101
SETD2down-regulatesRREB1activatesR-2292-3.4639416Pr-101
TP53down-regulatesRREB1activatesR-2292-3.4639416Pr-101
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2292-3.4639416Pr-101

Regulons in program Pr-101

Regulon Cox Hazard Ratio # genes # causal flows
R-1496-0.90475967
R-1909-1.53545133
R-840-2.2146782
R-292-2.43197713
R-2138-2.51196291
R-3196-2.6133166
R-1505-2.6810571
R-3182-2.83908196
R-313-2.85877916
R-330-2.958471310
R-1903-3.0283981
R-2161-3.07199159
R-2368-3.16004129
R-2292-3.46394169

Genes in program Pr-101

EnsEMBL IdEntrez IdPreferred
ENSG00000186814 100101467ZSCAN30
ENSG00000203965 84455EFCAB7
ENSG00000250151 100526693ARPC4-TTLL3
ENSG00000106004 3202HOXA5
ENSG00000274803 55814BDP1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions