Program

Causal Mechanistic Flows with regulons in program Pr-137

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesRORArepressesR-2269-0.01015511Pr-137
ANK2down-regulatesHOXD1activatesR-1302-0.04064268Pr-137
DIS3up-regulatesHOXD1activatesR-1302-0.04064268Pr-137
FGFR3up-regulatesHOXD1activatesR-1302-0.04064268Pr-137
MAXup-regulatesHOXD1activatesR-1302-0.04064268Pr-137
NFKB2down-regulatesHOXD1activatesR-1302-0.04064268Pr-137
RNASeq_FGFR3_Callup-regulatesHOXD1activatesR-1302-0.04064268Pr-137
MYCdown-regulatesHOXD1activatesR-1302-0.04064268Pr-137
t(4;14)up-regulatesHOXD1activatesR-1302-0.04064268Pr-137
t(4;14)_cytogeneticup-regulatesHOXD1activatesR-1302-0.04064268Pr-137
AHNAK2down-regulatesIRF1repressesR-1860.093249428Pr-137
del1pup-regulatesIRF1repressesR-1860.093249428Pr-137
AHNAK2down-regulatesMEF2ArepressesR-18760.11167822Pr-137
DCHS1down-regulatesMEF2ArepressesR-18760.11167822Pr-137
FAM46Cup-regulatesMEF2ArepressesR-18760.11167822Pr-137
FAT3down-regulatesMEF2ArepressesR-18760.11167822Pr-137
MAXdown-regulatesMEF2ArepressesR-18760.11167822Pr-137
NRASup-regulatesMEF2ArepressesR-18760.11167822Pr-137
PTPRDdown-regulatesMEF2ArepressesR-18760.11167822Pr-137
RNASeq_CCND2_Calldown-regulatesMEF2ArepressesR-18760.11167822Pr-137
RNASeq_FGFR3_Calldown-regulatesMEF2ArepressesR-18760.11167822Pr-137
t(4;14)down-regulatesMEF2ArepressesR-18760.11167822Pr-137
TACC2down-regulatesMEF2ArepressesR-18760.11167822Pr-137
AHNAK2down-regulatesFLI1repressesR-790-0.1356879Pr-137
FAM46Cup-regulatesFLI1repressesR-790-0.1356879Pr-137
FAT3down-regulatesFLI1repressesR-790-0.1356879Pr-137
MACF1down-regulatesFLI1repressesR-790-0.1356879Pr-137
MAXdown-regulatesFLI1repressesR-790-0.1356879Pr-137
NRASup-regulatesFLI1repressesR-790-0.1356879Pr-137
PTPRDdown-regulatesFLI1repressesR-790-0.1356879Pr-137
PTPRTdown-regulatesFLI1repressesR-790-0.1356879Pr-137
t(11;14)down-regulatesFLI1repressesR-790-0.1356879Pr-137
RNASeq_CCND2_Calldown-regulatesFLI1repressesR-790-0.1356879Pr-137
RNASeq_MAFA_Calldown-regulatesFLI1repressesR-790-0.1356879Pr-137
t(14;16)down-regulatesFLI1repressesR-790-0.1356879Pr-137
t(11;14)_cytogeneticdown-regulatesFLI1repressesR-790-0.1356879Pr-137
t(14;16)_cytogeneticdown-regulatesFLI1repressesR-790-0.1356879Pr-137
AHNAK2down-regulatesELF2repressesR-972-0.14487113Pr-137
PCDH10down-regulatesELF2repressesR-972-0.14487113Pr-137
PTPRDdown-regulatesELF2repressesR-972-0.14487113Pr-137
AHNAK2down-regulatesFLI1repressesR-7820.15223917Pr-137
DIS3down-regulatesFLI1repressesR-7820.15223917Pr-137
FAM46Cup-regulatesFLI1repressesR-7820.15223917Pr-137
HUWE1down-regulatesFLI1repressesR-7820.15223917Pr-137
MAXdown-regulatesFLI1repressesR-7820.15223917Pr-137
PRKD2down-regulatesFLI1repressesR-7820.15223917Pr-137
PTPRDdown-regulatesFLI1repressesR-7820.15223917Pr-137
PTPRTdown-regulatesFLI1repressesR-7820.15223917Pr-137
t(11;14)down-regulatesFLI1repressesR-7820.15223917Pr-137
RNASeq_CCND2_Calldown-regulatesFLI1repressesR-7820.15223917Pr-137
RNASeq_FGFR3_Calldown-regulatesFLI1repressesR-7820.15223917Pr-137
t(4;14)down-regulatesFLI1repressesR-7820.15223917Pr-137
SETD2down-regulatesFLI1repressesR-7820.15223917Pr-137
t(4;14)_cytogeneticdown-regulatesFLI1repressesR-7820.15223917Pr-137
AHNAK2down-regulatesNFKB1repressesR-1579-0.26008516Pr-137
DCHS1down-regulatesNFKB1repressesR-1579-0.26008516Pr-137
DIS3down-regulatesNFKB1repressesR-1579-0.26008516Pr-137
FAM46Cup-regulatesNFKB1repressesR-1579-0.26008516Pr-137
MAXdown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
PTPRDdown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
RNASeq_CCND2_Calldown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
RNASeq_FGFR3_Calldown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
t(4;14)down-regulatesNFKB1repressesR-1579-0.26008516Pr-137
SVILdown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
ZFHX3down-regulatesNFKB1repressesR-1579-0.26008516Pr-137
t(4;14)_cytogeneticdown-regulatesNFKB1repressesR-1579-0.26008516Pr-137
AHNAK2down-regulatesIRF9repressesR-11500.38394623Pr-137
NFKB2up-regulatesIRF9repressesR-11500.38394623Pr-137
AHNAK2down-regulatesETV6repressesR-7040.46943913Pr-137
PCDH10down-regulatesETV6repressesR-7040.46943913Pr-137
del1pup-regulatesETV6repressesR-7040.46943913Pr-137
RNASeq_CCND2_Calldown-regulatesGABPB1repressesR-1950-0.4793848Pr-137
del13up-regulatesGABPB1repressesR-1950-0.4793848Pr-137
DIS3up-regulatesJUNactivatesR-11750.67878324Pr-137
t(11;14)up-regulatesJUNactivatesR-11750.67878324Pr-137
MYCdown-regulatesJUNactivatesR-11750.67878324Pr-137
PCDH7up-regulatesGABPAactivatesR-1457-1.1197911Pr-137
RELNup-regulatesGABPAactivatesR-1457-1.1197911Pr-137
XIRP2up-regulatesGABPAactivatesR-1457-1.1197911Pr-137
del13down-regulatesGABPAactivatesR-1457-1.1197911Pr-137
KIAA1244down-regulatesDLX4activatesR-1988-1.199887Pr-137
MAXup-regulatesDLX4activatesR-1988-1.199887Pr-137
NFKB2down-regulatesDLX4activatesR-1988-1.199887Pr-137
RNASeq_FGFR3_Callup-regulatesDLX4activatesR-1988-1.199887Pr-137
RNASeq_MAFA_Calldown-regulatesDLX4activatesR-1988-1.199887Pr-137
t(14;16)down-regulatesDLX4activatesR-1988-1.199887Pr-137
t(4;14)up-regulatesDLX4activatesR-1988-1.199887Pr-137
t(4;14)_cytogeneticup-regulatesDLX4activatesR-1988-1.199887Pr-137
AHNAK2up-regulatesARID3AactivatesR-13451.38369Pr-137
DSTup-regulatesARID3AactivatesR-13451.38369Pr-137
t(11;14)down-regulatesARID3AactivatesR-13451.38369Pr-137
del13up-regulatesETV6repressesR-713-1.616459Pr-137
IRF4up-regulatesENSG00000165066repressesR-30841.776336Pr-137
RELNdown-regulatesENSG00000165066repressesR-30841.776336Pr-137
t(11;14)up-regulatesENSG00000165066repressesR-30841.776336Pr-137
t(14;16)down-regulatesENSG00000165066repressesR-30841.776336Pr-137
SP140down-regulatesENSG00000165066repressesR-30841.776336Pr-137
t(11;14)_cytogeneticup-regulatesENSG00000165066repressesR-30841.776336Pr-137
AHNAK2down-regulatesBARX2repressesR-2912.1339514Pr-137
DIS3down-regulatesBARX2repressesR-2912.1339514Pr-137
FAM46Cup-regulatesBARX2repressesR-2912.1339514Pr-137
MAXdown-regulatesBARX2repressesR-2912.1339514Pr-137
PTPRDdown-regulatesBARX2repressesR-2912.1339514Pr-137
RNASeq_CCND2_Calldown-regulatesBARX2repressesR-2912.1339514Pr-137
RNASeq_FGFR3_Calldown-regulatesBARX2repressesR-2912.1339514Pr-137
MYCup-regulatesBARX2repressesR-2912.1339514Pr-137
t(4;14)down-regulatesBARX2repressesR-2912.1339514Pr-137
ZFHX3down-regulatesBARX2repressesR-2912.1339514Pr-137
t(4;14)_cytogeneticdown-regulatesBARX2repressesR-2912.1339514Pr-137
AHNAK2down-regulatesFLI1repressesR-7842.1967112Pr-137
DIS3down-regulatesFLI1repressesR-7842.1967112Pr-137
FAM46Cup-regulatesFLI1repressesR-7842.1967112Pr-137
FAT3down-regulatesFLI1repressesR-7842.1967112Pr-137
HUWE1down-regulatesFLI1repressesR-7842.1967112Pr-137
IRF4down-regulatesFLI1repressesR-7842.1967112Pr-137
MACF1down-regulatesFLI1repressesR-7842.1967112Pr-137
MAXdown-regulatesFLI1repressesR-7842.1967112Pr-137
PRKD2down-regulatesFLI1repressesR-7842.1967112Pr-137
t(11;14)down-regulatesFLI1repressesR-7842.1967112Pr-137
RNASeq_CCND2_Calldown-regulatesFLI1repressesR-7842.1967112Pr-137
RNASeq_FGFR3_Calldown-regulatesFLI1repressesR-7842.1967112Pr-137
t(4;14)down-regulatesFLI1repressesR-7842.1967112Pr-137
SETD2down-regulatesFLI1repressesR-7842.1967112Pr-137
t(11;14)_cytogeneticdown-regulatesFLI1repressesR-7842.1967112Pr-137
t(14;16)_cytogeneticdown-regulatesFLI1repressesR-7842.1967112Pr-137
t(4;14)_cytogeneticdown-regulatesFLI1repressesR-7842.1967112Pr-137
RNASeq_MAFA_Callup-regulatesARID3AactivatesR-1348-2.220438Pr-137
t(14;16)_cytogeneticup-regulatesARID3AactivatesR-1348-2.220438Pr-137
DMDup-regulatesSMAD3repressesR-29652.282847Pr-137
IRF4up-regulatesSMAD3repressesR-29652.282847Pr-137
NRASdown-regulatesSMAD3repressesR-29652.282847Pr-137
t(11;14)up-regulatesSMAD3repressesR-29652.282847Pr-137
RNASeq_MAFA_Callup-regulatesSMAD3repressesR-29652.282847Pr-137
t(11;14)_cytogeneticup-regulatesSMAD3repressesR-29652.282847Pr-137
AHNAK2down-regulatesBBXrepressesR-15332.41213Pr-137
DNAH5down-regulatesBBXrepressesR-15332.41213Pr-137
FAT3down-regulatesBBXrepressesR-15332.41213Pr-137
MAXdown-regulatesBBXrepressesR-15332.41213Pr-137
RNASeq_CCND2_Calldown-regulatesBBXrepressesR-15332.41213Pr-137
ZNF208down-regulatesBBXrepressesR-15332.41213Pr-137
ACTG1up-regulatesNR2F6activatesR-1377-3.22910Pr-137
DSTup-regulatesNR2F6activatesR-1377-3.22910Pr-137
RNASeq_CCND2_Callup-regulatesNR2F6activatesR-1377-3.22910Pr-137
RNASeq_MAFA_Calldown-regulatesNR2F6activatesR-1377-3.22910Pr-137
RNASeq_MAFB_Calldown-regulatesNR2F6activatesR-1377-3.22910Pr-137
t(14;16)down-regulatesNR2F6activatesR-1377-3.22910Pr-137
del13down-regulatesNR2F6activatesR-1377-3.22910Pr-137

Regulons in program Pr-137

Regulon Cox Hazard Ratio # genes # causal flows
R-2269-0.010155111
R-1302-0.040642689
R-1860.0932494282
R-18760.1116782211
R-790-0.135687914
R-972-0.144871133
R-7820.1522391714
R-1579-0.2600851612
R-11500.383946232
R-7040.469439133
R-1950-0.47938482
R-11750.678783243
R-1457-1.11979114
R-1988-1.1998878
R-13451.383693
R-713-1.6164591
R-30841.7763366
R-2912.133951411
R-7842.196711217
R-1348-2.2204382
R-29652.2828476
R-15332.412136
R-1377-3.229107

Genes in program Pr-137

EnsEMBL IdEntrez IdPreferred
ENSG00000175538 10008KCNE3
ENSG00000175600 79783SUGCT
ENSG00000176087 113829SLC35A4
ENSG00000176340 1351COX8A
ENSG00000176532 222171PRR15
ENSG00000176732 375189PFN4
ENSG00000176853 157769FAM91A1
ENSG00000177728 9772TMEM94
ENSG00000179476 122525C14orf28
ENSG00000180917 55783CMTR2
ENSG00000181019 1728NQO1
ENSG00000184083 54954FAM120C
ENSG00000196396 5770PTPN1
ENSG00000197119 123096SLC25A29
ENSG00000198498 55319TMA16
ENSG00000204899 440145MZT1
ENSG00000213923 1454CSNK1E
ENSG00000243335 154881KCTD7
ENSG00000248485
ENSG00000250506 1018CDK3
ENSG00000255112 57132CHMP1B
ENSG00000269897 100532731COMMD3-BMI1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions