Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TP53

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
STAT1up-regulatesR-3071-0.0145432Pr-133
STAT3down-regulatesR-311-0.0731142Pr-135
RREB1down-regulatesR-2304-0.103823Pr-135
ATF3down-regulatesR-2412-0.107523Pr-10
RUNX3up-regulatesR-895-0.107786Pr-90
ATF3down-regulatesR-2410-0.14054Pr-3
RREB1down-regulatesR-22990.160797Pr-120
THRAdown-regulatesR-620.204827Pr-117
NF1down-regulatesR-127-0.22305Pr-18
IRF7up-regulatesR-1086-0.243887Pr-41
ATF3down-regulatesR-2409-0.31315Pr-0
TFE3down-regulatesR-558-0.31956Pr-39
ZFXdown-regulatesR-1927-0.36742Pr-5
RREB1down-regulatesR-2284-0.436433Pr-14
JUNdown-regulatesR-11770.50809Pr-138
E2F2up-regulatesR-2943-0.530398Pr-58
THRAdown-regulatesR-59-0.644538Pr-30
ELF3down-regulatesR-2141-0.655011Pr-39
IRF7up-regulatesR-10830.674001Pr-124
JUNdown-regulatesR-11860.700789Pr-75
STAT1up-regulatesR-30690.785822Pr-124
VBP1up-regulatesR-21000.788348Pr-0
ELF3down-regulatesR-2151-0.794443Pr-22
BBXdown-regulatesR-1536-0.809151Pr-10
ZNF691up-regulatesR-3007-0.816485Pr-2
IRF9up-regulatesR-11490.851839Pr-124
IRF7up-regulatesR-1084-0.861526Pr-40
RREB1down-regulatesR-2293-0.862205Pr-135
IRF1up-regulatesR-1820.909345Pr-124
ZNF691up-regulatesR-30080.909713Pr-62
JUNdown-regulatesR-11810.916484Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

JUNdown-regulatesR-1184-0.962738Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

ENSG00000165066up-regulatesR-30800.967824Pr-131
IRF7up-regulatesR-1092-0.976053Pr-40
GABPAup-regulatesR-1456-1.00351Pr-37
GABPAup-regulatesR-1454-1.00665Pr-135
IRF9up-regulatesR-1152-1.01235Pr-40
SRFdown-regulatesR-1790-1.04379Pr-27
IRF7up-regulatesR-1090-1.0469Pr-40
IRF1up-regulatesR-192-1.06726Pr-40
IRF9up-regulatesR-1154-1.10025Pr-40
BRCA1up-regulatesR-10321.10039Pr-117
RREB1down-regulatesR-2298-1.11227Pr-6
RARAdown-regulatesR-1571.1957Pr-117
ATF1up-regulatesR-571-1.19606Pr-10
RARAdown-regulatesR-1641.24046Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

E2F2up-regulatesR-2946-1.27434Pr-15
IRF9up-regulatesR-11581.2922Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

GABPAup-regulatesR-14551.3231Pr-135
POU2F2down-regulatesR-25121.37817Pr-62
ZBTB3up-regulatesR-12681.42882Pr-127
GABPAup-regulatesR-14521.4809Pr-136
JUNdown-regulatesR-1179-1.50896Pr-129
SRFdown-regulatesR-17841.54282Pr-127
KLF7down-regulatesR-281-1.54497Pr-12
ZBTB3up-regulatesR-12711.5513Pr-117
SPDEFdown-regulatesR-19741.59808Pr-63
RREB1down-regulatesR-2291-1.6207Pr-12
SPDEFdown-regulatesR-1976-1.62216Pr-10
ZFXdown-regulatesR-1918-1.62764Pr-10
MYBup-regulatesR-6231.65419Pr-96
VBP1up-regulatesR-21021.67538Pr-73
ELF3down-regulatesR-2149-1.67654Pr-10
ZBTB4down-regulatesR-20901.72041Pr-117
ZBTB3up-regulatesR-1263-1.74288Pr-15
MAZup-regulatesR-511-1.75904Pr-0
CEBPZup-regulatesR-7581.76604Pr-54
MAZup-regulatesR-4951.8487Pr-87
KLF7down-regulatesR-289-1.856Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ENSG00000176887up-regulatesR-19001.8751Pr-122
E2F2up-regulatesR-29451.88745Pr-133
NRF1down-regulatesR-27051.91369Pr-136
NRF1down-regulatesR-27041.94607Pr-117
RREB1down-regulatesR-2302-1.95334Pr-10
SPDEFdown-regulatesR-19641.96106Pr-127
CREB1down-regulatesR-274-1.97415Pr-10
PRDM4down-regulatesR-30752.00508Pr-73
E4F1down-regulatesR-3148-2.09252Pr-58
KLF7down-regulatesR-288-2.09925Pr-2
RUNX2up-regulatesR-1282-2.24394Pr-94
CREB1down-regulatesR-278-2.27835Pr-11
TCF7L1down-regulatesR-3170-2.27892Pr-14
RREB1down-regulatesR-2286-2.31249Pr-17
RUNX2up-regulatesR-12832.3191Pr-123
MAZup-regulatesR-499-2.32628Pr-11
GABPAup-regulatesR-1458-2.32781Pr-37
NR4A2down-regulatesR-1716-2.35911Pr-17
RARAdown-regulatesR-167-2.36681Pr-3
PATZ1up-regulatesR-21962.39409Pr-55
RARAdown-regulatesR-1692.42125Pr-138
RREB1down-regulatesR-2289-2.4348Pr-94
SRFdown-regulatesR-17862.43898Pr-117
BRCA1up-regulatesR-1033-2.58375Pr-12
RARAdown-regulatesR-151-2.63142Pr-61
BRCA1up-regulatesR-10312.71498Pr-123
RUNX3up-regulatesR-8982.74094Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

TCF7L1down-regulatesR-3173-2.7488Pr-11
IRF1up-regulatesR-1852.8096Pr-123
NRF1down-regulatesR-27032.85746Pr-72
ATF4down-regulatesR-95-2.89504Pr-10
NFIAup-regulatesR-354-2.9087Pr-60
JUNdown-regulatesR-1176-2.91332Pr-94
SPDEFdown-regulatesR-1966-2.98845Pr-11
STAT5Bup-regulatesR-23673.00488Pr-123
IRF1up-regulatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

POU2F2down-regulatesR-2519-3.13355Pr-104
MYBup-regulatesR-6163.1672Pr-123
ENSG00000138795up-regulatesR-273.20229Pr-122
MAZup-regulatesR-5053.21974Pr-70
ENSG00000165066up-regulatesR-30823.32738Pr-63
IRF7up-regulatesR-10873.35543Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ENSG00000176887up-regulatesR-18923.42989Pr-122
BRCA1up-regulatesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RREB1down-regulatesR-2292-3.46394Pr-101
MYBup-regulatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

MAZup-regulatesR-512-3.50135Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

POU2F2down-regulatesR-2511-3.52119Pr-100
ZFXdown-regulatesR-1921-3.52781Pr-11
STAT5Bup-regulatesR-23703.57469Pr-122
RARAdown-regulatesR-166-3.60154Pr-20
ENSG00000176887up-regulatesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

STAT3down-regulatesR-307-3.61941Pr-11
ENSG00000165066up-regulatesR-30813.73477Pr-128
KLF7down-regulatesR-2853.90122Pr-74
YY1up-regulatesR-25253.91807Pr-122
POU2F2down-regulatesR-2520-3.9229Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

SRFdown-regulatesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MAZup-regulatesR-509-4.01621Pr-42
NFIAup-regulatesR-3554.10051Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SRFdown-regulatesR-17814.13916Pr-70
E2F8up-regulatesR-16294.14363Pr-136
RREB1down-regulatesR-2287-4.14495Pr-100
KLF7down-regulatesR-280-4.33884Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NRF1down-regulatesR-27104.52843Pr-72
SRFdown-regulatesR-17854.55548Pr-63
MAZup-regulatesR-506-4.85353Pr-4
E2F1up-regulatesR-21745.04725Pr-63
IRF7up-regulatesR-10885.08481Pr-63
SRFdown-regulatesR-1787-5.29074Pr-104
MYBup-regulatesR-621-5.47246Pr-104
MYBup-regulatesR-6185.69454Pr-108
KLF7down-regulatesR-2837.07253Pr-68
SRFdown-regulatesR-17807.20867Pr-71
ARID5Bdown-regulatesR-10967.71326Pr-68
POU2F2down-regulatesR-25188.01545Pr-68
MYBup-regulatesR-6148.54513Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F8up-regulatesR-16288.73321Pr-71
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions