Program

Causal Mechanistic Flows with regulons in program Pr-123

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DNAH10up-regulatesBHLHE40activatesR-9431.645437Pr-123
MYH2down-regulatesBHLHE40activatesR-9431.645437Pr-123
t(11;14)up-regulatesBHLHE40activatesR-9431.645437Pr-123
RYR2down-regulatesBHLHE40activatesR-9431.645437Pr-123
SIdown-regulatesBHLHE40activatesR-9431.645437Pr-123
t(14;16)_cytogeneticdown-regulatesBHLHE40activatesR-9431.645437Pr-123
DIS3up-regulatesENSG00000128652activatesR-22601.9390613Pr-123
FGFR3up-regulatesENSG00000128652activatesR-22601.9390613Pr-123
LAMA1down-regulatesENSG00000128652activatesR-22601.9390613Pr-123
MUC16down-regulatesENSG00000128652activatesR-22601.9390613Pr-123
PRKD2up-regulatesENSG00000128652activatesR-22601.9390613Pr-123
RNASeq_FGFR3_Callup-regulatesENSG00000128652activatesR-22601.9390613Pr-123
t(4;14)up-regulatesENSG00000128652activatesR-22601.9390613Pr-123
del13up-regulatesENSG00000128652activatesR-22601.9390613Pr-123
t(4;14)_cytogeneticup-regulatesENSG00000128652activatesR-22601.9390613Pr-123
DIS3up-regulatesENSG00000175745activatesR-5141.9540417Pr-123
FGFR3up-regulatesENSG00000175745activatesR-5141.9540417Pr-123
PRKD2up-regulatesENSG00000175745activatesR-5141.9540417Pr-123
RNASeq_FGFR3_Callup-regulatesENSG00000175745activatesR-5141.9540417Pr-123
RNASeq_MAFA_Calldown-regulatesENSG00000175745activatesR-5141.9540417Pr-123
t(4;14)up-regulatesENSG00000175745activatesR-5141.9540417Pr-123
ZANdown-regulatesENSG00000175745activatesR-5141.9540417Pr-123
t(14;16)_cytogeneticdown-regulatesENSG00000175745activatesR-5141.9540417Pr-123
t(4;14)_cytogeneticup-regulatesENSG00000175745activatesR-5141.9540417Pr-123
BAI3down-regulatesRUNX2activatesR-12832.319115Pr-123
COL6A5down-regulatesRUNX2activatesR-12832.319115Pr-123
CYLDdown-regulatesRUNX2activatesR-12832.319115Pr-123
DIS3up-regulatesRUNX2activatesR-12832.319115Pr-123
DNAH10up-regulatesRUNX2activatesR-12832.319115Pr-123
DUSP2down-regulatesRUNX2activatesR-12832.319115Pr-123
EYSdown-regulatesRUNX2activatesR-12832.319115Pr-123
FGFR3up-regulatesRUNX2activatesR-12832.319115Pr-123
FRAS1up-regulatesRUNX2activatesR-12832.319115Pr-123
IRF4up-regulatesRUNX2activatesR-12832.319115Pr-123
KIAA1244down-regulatesRUNX2activatesR-12832.319115Pr-123
LAMA1down-regulatesRUNX2activatesR-12832.319115Pr-123
LTBup-regulatesRUNX2activatesR-12832.319115Pr-123
MYO10down-regulatesRUNX2activatesR-12832.319115Pr-123
PRKD2up-regulatesRUNX2activatesR-12832.319115Pr-123
t(11;14)up-regulatesRUNX2activatesR-12832.319115Pr-123
RNASeq_CCND2_Calldown-regulatesRUNX2activatesR-12832.319115Pr-123
RNASeq_FGFR3_Callup-regulatesRUNX2activatesR-12832.319115Pr-123
t(4;14)up-regulatesRUNX2activatesR-12832.319115Pr-123
RYR2down-regulatesRUNX2activatesR-12832.319115Pr-123
SVILdown-regulatesRUNX2activatesR-12832.319115Pr-123
TP53up-regulatesRUNX2activatesR-12832.319115Pr-123
XIRP2down-regulatesRUNX2activatesR-12832.319115Pr-123
ZANdown-regulatesRUNX2activatesR-12832.319115Pr-123
amp1qup-regulatesRUNX2activatesR-12832.319115Pr-123
t(11;14)_cytogeneticup-regulatesRUNX2activatesR-12832.319115Pr-123
t(14;16)_cytogeneticdown-regulatesRUNX2activatesR-12832.319115Pr-123
t(4;14)_cytogeneticup-regulatesRUNX2activatesR-12832.319115Pr-123
FGFR3down-regulatesNR2F6repressesR-13752.3400218Pr-123
IRF4down-regulatesNR2F6repressesR-13752.3400218Pr-123
PRKD2down-regulatesNR2F6repressesR-13752.3400218Pr-123
t(11;14)down-regulatesNR2F6repressesR-13752.3400218Pr-123
RNASeq_FGFR3_Calldown-regulatesNR2F6repressesR-13752.3400218Pr-123
t(4;14)down-regulatesNR2F6repressesR-13752.3400218Pr-123
SVILup-regulatesNR2F6repressesR-13752.3400218Pr-123
del13down-regulatesNR2F6repressesR-13752.3400218Pr-123
t(11;14)_cytogeneticdown-regulatesNR2F6repressesR-13752.3400218Pr-123
t(4;14)_cytogeneticdown-regulatesNR2F6repressesR-13752.3400218Pr-123
DIS3down-regulatesPAX6repressesR-15472.5866116Pr-123
FGFR3down-regulatesPAX6repressesR-15472.5866116Pr-123
IRF4down-regulatesPAX6repressesR-15472.5866116Pr-123
PRKD2down-regulatesPAX6repressesR-15472.5866116Pr-123
t(11;14)down-regulatesPAX6repressesR-15472.5866116Pr-123
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-15472.5866116Pr-123
t(4;14)down-regulatesPAX6repressesR-15472.5866116Pr-123
t(11;14)_cytogeneticdown-regulatesPAX6repressesR-15472.5866116Pr-123
t(4;14)_cytogeneticdown-regulatesPAX6repressesR-15472.5866116Pr-123
DIS3up-regulatesBRCA1activatesR-10312.714987Pr-123
DNAH10up-regulatesBRCA1activatesR-10312.714987Pr-123
FRAS1up-regulatesBRCA1activatesR-10312.714987Pr-123
IRF4up-regulatesBRCA1activatesR-10312.714987Pr-123
LTBup-regulatesBRCA1activatesR-10312.714987Pr-123
PRKD2up-regulatesBRCA1activatesR-10312.714987Pr-123
t(11;14)up-regulatesBRCA1activatesR-10312.714987Pr-123
RNASeq_FGFR3_Callup-regulatesBRCA1activatesR-10312.714987Pr-123
t(4;14)up-regulatesBRCA1activatesR-10312.714987Pr-123
TP53up-regulatesBRCA1activatesR-10312.714987Pr-123
ZNF208up-regulatesBRCA1activatesR-10312.714987Pr-123
amp1qup-regulatesBRCA1activatesR-10312.714987Pr-123
t(11;14)_cytogeneticup-regulatesBRCA1activatesR-10312.714987Pr-123
t(4;14)_cytogeneticup-regulatesBRCA1activatesR-10312.714987Pr-123
CYLDup-regulatesARID3ArepressesR-13392.7875520Pr-123
t(11;14)down-regulatesARID3ArepressesR-13392.7875520Pr-123
DIS3up-regulatesENSG00000162367activatesR-17062.8062423Pr-123
DNAH10up-regulatesENSG00000162367activatesR-17062.8062423Pr-123
PCLOdown-regulatesENSG00000162367activatesR-17062.8062423Pr-123
t(11;14)up-regulatesENSG00000162367activatesR-17062.8062423Pr-123
t(11;14)_cytogeneticup-regulatesENSG00000162367activatesR-17062.8062423Pr-123
t(14;16)_cytogeneticdown-regulatesENSG00000162367activatesR-17062.8062423Pr-123
BAI3down-regulatesIRF1activatesR-1852.809629Pr-123
DNAH10up-regulatesIRF1activatesR-1852.809629Pr-123
FGFR3up-regulatesIRF1activatesR-1852.809629Pr-123
KIAA1244down-regulatesIRF1activatesR-1852.809629Pr-123
PRKD2up-regulatesIRF1activatesR-1852.809629Pr-123
t(11;14)up-regulatesIRF1activatesR-1852.809629Pr-123
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-1852.809629Pr-123
TP53up-regulatesIRF1activatesR-1852.809629Pr-123
t(11;14)_cytogeneticup-regulatesIRF1activatesR-1852.809629Pr-123
DIS3down-regulatesHOXA5repressesR-232.905610Pr-123
DUSP2up-regulatesHOXA5repressesR-232.905610Pr-123
IRF4down-regulatesHOXA5repressesR-232.905610Pr-123
PRKD2down-regulatesHOXA5repressesR-232.905610Pr-123
t(11;14)down-regulatesHOXA5repressesR-232.905610Pr-123
RNASeq_FGFR3_Calldown-regulatesHOXA5repressesR-232.905610Pr-123
t(4;14)down-regulatesHOXA5repressesR-232.905610Pr-123
t(11;14)_cytogeneticdown-regulatesHOXA5repressesR-232.905610Pr-123
t(4;14)_cytogeneticdown-regulatesHOXA5repressesR-232.905610Pr-123
BAI3down-regulatesPBX1activatesR-21063.0000517Pr-123
CYLDdown-regulatesPBX1activatesR-21063.0000517Pr-123
DIS3up-regulatesPBX1activatesR-21063.0000517Pr-123
DUSP2down-regulatesPBX1activatesR-21063.0000517Pr-123
EYSdown-regulatesPBX1activatesR-21063.0000517Pr-123
FGFR3up-regulatesPBX1activatesR-21063.0000517Pr-123
KDM3Bdown-regulatesPBX1activatesR-21063.0000517Pr-123
PRKD2up-regulatesPBX1activatesR-21063.0000517Pr-123
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21063.0000517Pr-123
RNASeq_MAFA_Calldown-regulatesPBX1activatesR-21063.0000517Pr-123
t(4;14)up-regulatesPBX1activatesR-21063.0000517Pr-123
amp1qup-regulatesPBX1activatesR-21063.0000517Pr-123
t(4;14)_cytogeneticup-regulatesPBX1activatesR-21063.0000517Pr-123
DNAH10up-regulatesSTAT5BactivatesR-23673.0048812Pr-123
FGFR3up-regulatesSTAT5BactivatesR-23673.0048812Pr-123
NRASdown-regulatesSTAT5BactivatesR-23673.0048812Pr-123
RNASeq_CCND2_Calldown-regulatesSTAT5BactivatesR-23673.0048812Pr-123
RNASeq_FGFR3_Callup-regulatesSTAT5BactivatesR-23673.0048812Pr-123
t(4;14)up-regulatesSTAT5BactivatesR-23673.0048812Pr-123
TP53up-regulatesSTAT5BactivatesR-23673.0048812Pr-123
del13up-regulatesSTAT5BactivatesR-23673.0048812Pr-123
t(4;14)_cytogeneticup-regulatesSTAT5BactivatesR-23673.0048812Pr-123
t(14;16)_cytogeneticdown-regulatesENSG00000179348activatesR-10563.0793714Pr-123
DIS3up-regulatesMYBactivatesR-6163.167215Pr-123
IRF4up-regulatesMYBactivatesR-6163.167215Pr-123
t(11;14)up-regulatesMYBactivatesR-6163.167215Pr-123
RNASeq_FGFR3_Callup-regulatesMYBactivatesR-6163.167215Pr-123
t(4;14)up-regulatesMYBactivatesR-6163.167215Pr-123
TP53up-regulatesMYBactivatesR-6163.167215Pr-123
amp1qup-regulatesMYBactivatesR-6163.167215Pr-123
t(11;14)_cytogeneticup-regulatesMYBactivatesR-6163.167215Pr-123
t(4;14)_cytogeneticup-regulatesMYBactivatesR-6163.167215Pr-123
BAI3down-regulatesSTAT4activatesR-26503.5941417Pr-123
DNAH10up-regulatesSTAT4activatesR-26503.5941417Pr-123
FGFR3up-regulatesSTAT4activatesR-26503.5941417Pr-123
RNASeq_CCND2_Calldown-regulatesSTAT4activatesR-26503.5941417Pr-123
RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-26503.5941417Pr-123
t(4;14)up-regulatesSTAT4activatesR-26503.5941417Pr-123
SVILdown-regulatesSTAT4activatesR-26503.5941417Pr-123
t(4;14)_cytogeneticup-regulatesSTAT4activatesR-26503.5941417Pr-123
DNAH10up-regulatesFOXM1activatesR-14433.599687Pr-123
BAI3down-regulatesENSG00000136574activatesR-353.6565316Pr-123
CYLDdown-regulatesENSG00000136574activatesR-353.6565316Pr-123
FGFR3up-regulatesENSG00000136574activatesR-353.6565316Pr-123
KDM3Bdown-regulatesENSG00000136574activatesR-353.6565316Pr-123
LTBup-regulatesENSG00000136574activatesR-353.6565316Pr-123
NRASdown-regulatesENSG00000136574activatesR-353.6565316Pr-123
PRKD2up-regulatesENSG00000136574activatesR-353.6565316Pr-123
RNASeq_FGFR3_Callup-regulatesENSG00000136574activatesR-353.6565316Pr-123
t(4;14)up-regulatesENSG00000136574activatesR-353.6565316Pr-123
del13up-regulatesENSG00000136574activatesR-353.6565316Pr-123
t(4;14)_cytogeneticup-regulatesENSG00000136574activatesR-353.6565316Pr-123
DIS3down-regulatesHOXA3repressesR-2203.7597119Pr-123
DUSP2up-regulatesHOXA3repressesR-2203.7597119Pr-123
IRF4down-regulatesHOXA3repressesR-2203.7597119Pr-123
PRKD2down-regulatesHOXA3repressesR-2203.7597119Pr-123
t(11;14)down-regulatesHOXA3repressesR-2203.7597119Pr-123
RNASeq_FGFR3_Calldown-regulatesHOXA3repressesR-2203.7597119Pr-123
t(4;14)down-regulatesHOXA3repressesR-2203.7597119Pr-123
t(4;14)_cytogeneticdown-regulatesHOXA3repressesR-2203.7597119Pr-123

Regulons in program Pr-123

Regulon Cox Hazard Ratio # genes # causal flows
R-9431.6454376
R-22601.93906139
R-5141.95404179
R-12832.31911528
R-13752.340021810
R-15472.58661169
R-10312.71498714
R-13392.78755202
R-17062.80624236
R-1852.8096299
R-232.9056109
R-21063.000051713
R-23673.00488129
R-10563.07937141
R-6163.1672159
R-26503.59414178
R-14433.5996871
R-353.656531611
R-2203.75971198

Genes in program Pr-123

EnsEMBL IdEntrez IdPreferred
ENSG00000205336 9289ADGRG1
ENSG00000221968 3995FADS3
ENSG00000223953
ENSG00000257315 9877ZC3H11A
ENSG00000258366 51750RTEL1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions