Program

Causal Mechanistic Flows with regulons in program Pr-73

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5up-regulatesVBP1activatesR-21021.675386Pr-73
RELNup-regulatesVBP1activatesR-21021.675386Pr-73
RNASeq_MAFA_Callup-regulatesVBP1activatesR-21021.675386Pr-73
SYNE1up-regulatesVBP1activatesR-21021.675386Pr-73
TP53up-regulatesVBP1activatesR-21021.675386Pr-73
ZNF462up-regulatesVBP1activatesR-21021.675386Pr-73
t(14;16)_cytogeneticup-regulatesVBP1activatesR-21021.675386Pr-73
DNAH5down-regulatesHBP1repressesR-18441.975657Pr-73
MACF1down-regulatesHBP1repressesR-18441.975657Pr-73
t(11;14)up-regulatesHBP1repressesR-18441.975657Pr-73
TACC2down-regulatesHBP1repressesR-18441.975657Pr-73
TP53down-regulatesPRDM4repressesR-30752.005087Pr-73
TRAF3up-regulatesPRDM4repressesR-30752.005087Pr-73
amp1qup-regulatesPRDM4repressesR-30752.005087Pr-73
CMYA5down-regulatesCEBPBrepressesR-17602.4913520Pr-73
DIS3up-regulatesCEBPBrepressesR-17602.4913520Pr-73
IRF4up-regulatesCEBPBrepressesR-17602.4913520Pr-73
PRKD2up-regulatesCEBPBrepressesR-17602.4913520Pr-73
t(11;14)up-regulatesCEBPBrepressesR-17602.4913520Pr-73
del17pdown-regulatesCEBPBrepressesR-17602.4913520Pr-73
t(11;14)_cytogeneticup-regulatesCEBPBrepressesR-17602.4913520Pr-73
DNAH5down-regulatesHBP1repressesR-18302.7134520Pr-73
MACF1down-regulatesHBP1repressesR-18302.7134520Pr-73
t(11;14)up-regulatesHBP1repressesR-18302.7134520Pr-73
SYNE1down-regulatesHBP1repressesR-18302.7134520Pr-73
IRF4up-regulatesHSF4repressesR-1732.832227Pr-73
PRKD2up-regulatesHSF4repressesR-1732.832227Pr-73
t(11;14)up-regulatesHSF4repressesR-1732.832227Pr-73
RNASeq_MAFA_Calldown-regulatesHSF4repressesR-1732.832227Pr-73
RNASeq_MAFB_Calldown-regulatesHSF4repressesR-1732.832227Pr-73
t(14;16)down-regulatesHSF4repressesR-1732.832227Pr-73
SYNE1down-regulatesHSF4repressesR-1732.832227Pr-73
t(11;14)_cytogeneticup-regulatesHSF4repressesR-1732.832227Pr-73
t(14;16)_cytogeneticdown-regulatesHSF4repressesR-1732.832227Pr-73
DIS3down-regulatesFLI1activatesR-7813.0511119Pr-73
IRF4down-regulatesFLI1activatesR-7813.0511119Pr-73
t(11;14)down-regulatesFLI1activatesR-7813.0511119Pr-73
RNASeq_FGFR3_Calldown-regulatesFLI1activatesR-7813.0511119Pr-73
t(4;14)down-regulatesFLI1activatesR-7813.0511119Pr-73
TRAF3down-regulatesFLI1activatesR-7813.0511119Pr-73
del13down-regulatesFLI1activatesR-7813.0511119Pr-73
t(11;14)_cytogeneticdown-regulatesFLI1activatesR-7813.0511119Pr-73
RNASeq_MAFA_Calldown-regulatesFOXO3repressesR-27703.0595629Pr-73

Regulons in program Pr-73

Regulon Cox Hazard Ratio # genes # causal flows
R-21021.6753867
R-18441.9756574
R-30752.0050873
R-17602.49135207
R-18302.71345204
R-1732.8322279
R-7813.05111198
R-27703.05956291

Genes in program Pr-73

EnsEMBL IdEntrez IdPreferred
ENSG00000206013 387733IFITM5
ENSG00000225921 51406NOL7
ENSG00000230989 3281HSBP1
ENSG00000092067 1053CEBPE

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions