Program

Causal Mechanistic Flows with regulons in program Pr-94

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
IRF4down-regulatesFOXJ1repressesR-1852-0.6721957Pr-94
RNASeq_CCND2_Callup-regulatesFOXJ1repressesR-1852-0.6721957Pr-94
BAI3down-regulatesRUNX2repressesR-1282-2.2439417Pr-94
CYLDdown-regulatesRUNX2repressesR-1282-2.2439417Pr-94
FGFR3up-regulatesRUNX2repressesR-1282-2.2439417Pr-94
KIAA1244down-regulatesRUNX2repressesR-1282-2.2439417Pr-94
PRKD2up-regulatesRUNX2repressesR-1282-2.2439417Pr-94
RNASeq_FGFR3_Callup-regulatesRUNX2repressesR-1282-2.2439417Pr-94
t(4;14)up-regulatesRUNX2repressesR-1282-2.2439417Pr-94
TP53up-regulatesRUNX2repressesR-1282-2.2439417Pr-94
CMYA5down-regulatesRREB1activatesR-2289-2.434818Pr-94
DNAH10down-regulatesRREB1activatesR-2289-2.434818Pr-94
MXRA5down-regulatesRREB1activatesR-2289-2.434818Pr-94
PRKD2down-regulatesRREB1activatesR-2289-2.434818Pr-94
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2289-2.434818Pr-94
t(4;14)down-regulatesRREB1activatesR-2289-2.434818Pr-94
TP53down-regulatesRREB1activatesR-2289-2.434818Pr-94
CMYA5down-regulatesJUNactivatesR-1176-2.9133222Pr-94
DIS3up-regulatesJUNactivatesR-1176-2.9133222Pr-94
KIAA1109down-regulatesJUNactivatesR-1176-2.9133222Pr-94
MXRA5down-regulatesJUNactivatesR-1176-2.9133222Pr-94
PKHD1L1down-regulatesJUNactivatesR-1176-2.9133222Pr-94
t(11;14)up-regulatesJUNactivatesR-1176-2.9133222Pr-94
TP53down-regulatesJUNactivatesR-1176-2.9133222Pr-94
t(11;14)_cytogeneticup-regulatesJUNactivatesR-1176-2.9133222Pr-94
ATMup-regulatesNR3C1activatesR-3180-2.9529119Pr-94
CYLDup-regulatesNR3C1activatesR-3180-2.9529119Pr-94
MYO10up-regulatesNR3C1activatesR-3180-2.9529119Pr-94
NRASdown-regulatesNR3C1activatesR-3180-2.9529119Pr-94
RNASeq_MAFB_Callup-regulatesNR3C1activatesR-3180-2.9529119Pr-94
t(14;16)up-regulatesNR3C1activatesR-3180-2.9529119Pr-94
TRAF3up-regulatesNR3C1activatesR-3180-2.9529119Pr-94
ZNF208down-regulatesNR3C1activatesR-3180-2.9529119Pr-94
ATMup-regulatesJDP2activatesR-357-3.2230713Pr-94
CSMD1up-regulatesJDP2activatesR-357-3.2230713Pr-94
NRASdown-regulatesJDP2activatesR-357-3.2230713Pr-94
RNASeq_MAFA_Callup-regulatesJDP2activatesR-357-3.2230713Pr-94
RNASeq_MAFB_Callup-regulatesJDP2activatesR-357-3.2230713Pr-94
t(14;16)up-regulatesJDP2activatesR-357-3.2230713Pr-94
amp1qup-regulatesJDP2activatesR-357-3.2230713Pr-94
t(11;14)up-regulatesFOXO1activatesR-1402-3.53226Pr-94
t(11;14)up-regulatesFOXJ2activatesR-1428-3.7536729Pr-94
t(14;16)up-regulatesFOXJ2activatesR-1428-3.7536729Pr-94

Regulons in program Pr-94

Regulon Cox Hazard Ratio # genes # causal flows
R-1852-0.67219572
R-1282-2.24394178
R-2289-2.4348187
R-1176-2.91332228
R-3180-2.95291198
R-357-3.22307137
R-1402-3.532261
R-1428-3.75367292

Genes in program Pr-94

EnsEMBL IdEntrez IdPreferred
ENSG00000183971 283869NPW
ENSG00000253250 100127983C8orf88
ENSG00000129911 83855KLF16

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions