Program

Causal Mechanistic Flows with regulons in program Pr-70

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FAT3down-regulatesNFATC2repressesR-16942.422159Pr-70
PCDH10down-regulatesNFATC2repressesR-16942.422159Pr-70
AHNAK2up-regulatesMAZactivatesR-5053.2197410Pr-70
DCHS1up-regulatesMAZactivatesR-5053.2197410Pr-70
FAT3up-regulatesMAZactivatesR-5053.2197410Pr-70
MACF1up-regulatesMAZactivatesR-5053.2197410Pr-70
MUC12up-regulatesMAZactivatesR-5053.2197410Pr-70
NRASdown-regulatesMAZactivatesR-5053.2197410Pr-70
RELNup-regulatesMAZactivatesR-5053.2197410Pr-70
RNASeq_MAFA_Callup-regulatesMAZactivatesR-5053.2197410Pr-70
RNASeq_MAFB_Callup-regulatesMAZactivatesR-5053.2197410Pr-70
TP53up-regulatesMAZactivatesR-5053.2197410Pr-70
del17up-regulatesMAZactivatesR-5053.2197410Pr-70
t(14;16)_cytogeneticup-regulatesMAZactivatesR-5053.2197410Pr-70
AHNAK2down-regulatesRELArepressesR-14643.322578Pr-70
DCHS1down-regulatesRELArepressesR-14643.322578Pr-70
DNAH5down-regulatesRELArepressesR-14643.322578Pr-70
FAT3down-regulatesRELArepressesR-14643.322578Pr-70
MACF1down-regulatesRELArepressesR-14643.322578Pr-70
RNASeq_MAFA_Calldown-regulatesRELArepressesR-14643.322578Pr-70
SYNE1down-regulatesRELArepressesR-14643.322578Pr-70
TACC2down-regulatesRELArepressesR-14643.322578Pr-70
DCHS1up-regulatesNFYCactivatesR-2963.813558Pr-70
DIS3up-regulatesNFYCactivatesR-2963.813558Pr-70
FAM46Cdown-regulatesNFYCactivatesR-2963.813558Pr-70
t(11;14)up-regulatesNFYCactivatesR-2963.813558Pr-70
t(4;14)up-regulatesNFYCactivatesR-2963.813558Pr-70
ROBO1down-regulatesNFYCactivatesR-2963.813558Pr-70
t(11;14)_cytogeneticup-regulatesNFYCactivatesR-2963.813558Pr-70
AHNAK2down-regulatesSRFrepressesR-17814.1391635Pr-70
DIS3down-regulatesSRFrepressesR-17814.1391635Pr-70
FAM46Cup-regulatesSRFrepressesR-17814.1391635Pr-70
FAT3down-regulatesSRFrepressesR-17814.1391635Pr-70
IRF4down-regulatesSRFrepressesR-17814.1391635Pr-70
MACF1down-regulatesSRFrepressesR-17814.1391635Pr-70
t(11;14)down-regulatesSRFrepressesR-17814.1391635Pr-70
RNASeq_FGFR3_Calldown-regulatesSRFrepressesR-17814.1391635Pr-70
RNASeq_MAFA_Calldown-regulatesSRFrepressesR-17814.1391635Pr-70
RNASeq_MAFB_Calldown-regulatesSRFrepressesR-17814.1391635Pr-70
t(14;16)down-regulatesSRFrepressesR-17814.1391635Pr-70
t(4;14)down-regulatesSRFrepressesR-17814.1391635Pr-70
SYNE1down-regulatesSRFrepressesR-17814.1391635Pr-70
TACC2down-regulatesSRFrepressesR-17814.1391635Pr-70
TP53down-regulatesSRFrepressesR-17814.1391635Pr-70
ZNF462down-regulatesSRFrepressesR-17814.1391635Pr-70
AHNAK2down-regulatesELF1repressesR-29764.3880622Pr-70
BAI3down-regulatesELF1repressesR-29764.3880622Pr-70
TRAF3down-regulatesELF1repressesR-29764.3880622Pr-70
DIS3up-regulatesNFYAactivatesR-14694.5579221Pr-70
t(11;14)up-regulatesNFYAactivatesR-14694.5579221Pr-70
RNASeq_FGFR3_Callup-regulatesNFYAactivatesR-14694.5579221Pr-70
t(4;14)up-regulatesNFYAactivatesR-14694.5579221Pr-70
AHNAK2down-regulatesPOU2F1repressesR-734.6229937Pr-70
CMYA5down-regulatesPOU2F1repressesR-734.6229937Pr-70
DNAH5down-regulatesPOU2F1repressesR-734.6229937Pr-70
FAT3down-regulatesPOU2F1repressesR-734.6229937Pr-70
MACF1down-regulatesPOU2F1repressesR-734.6229937Pr-70
MAGI1down-regulatesPOU2F1repressesR-734.6229937Pr-70
PTPRDdown-regulatesPOU2F1repressesR-734.6229937Pr-70
TACC2down-regulatesPOU2F1repressesR-734.6229937Pr-70
LRP1Bdown-regulatesBHLHE40repressesR-9424.746398Pr-70
SYNE1down-regulatesBHLHE40repressesR-9424.746398Pr-70
TRAF3down-regulatesBHLHE40repressesR-9424.746398Pr-70
t(14;16)_cytogeneticdown-regulatesBHLHE40repressesR-9424.746398Pr-70
AHNAK2down-regulatesHBP1repressesR-18474.927096Pr-70
DCHS1down-regulatesHBP1repressesR-18474.927096Pr-70
DNAH5down-regulatesHBP1repressesR-18474.927096Pr-70
FAT3down-regulatesHBP1repressesR-18474.927096Pr-70
MACF1down-regulatesHBP1repressesR-18474.927096Pr-70
MAGI1down-regulatesHBP1repressesR-18474.927096Pr-70
PTPRDdown-regulatesHBP1repressesR-18474.927096Pr-70
SYNE1down-regulatesHBP1repressesR-18474.927096Pr-70
TACC2down-regulatesHBP1repressesR-18474.927096Pr-70
AHNAK2down-regulatesRORArepressesR-22814.957556Pr-70
KDM3Bdown-regulatesRORArepressesR-22814.957556Pr-70
del13up-regulatesRORArepressesR-22814.957556Pr-70
AHNAK2down-regulatesELF1repressesR-29925.065857Pr-70
PCDH10down-regulatesELF1repressesR-29925.065857Pr-70

Regulons in program Pr-70

Regulon Cox Hazard Ratio # genes # causal flows
R-16942.4221592
R-5053.219741012
R-14643.3225788
R-2963.8135587
R-17814.139163516
R-29764.38806223
R-14694.55792214
R-734.62299378
R-9424.7463984
R-18474.9270969
R-22814.9575563
R-29925.0658572

Genes in program Pr-70

EnsEMBL IdEntrez IdPreferred
ENSG00000273173 8926SNURF

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions