Program

Causal Mechanistic Flows with regulons in program Pr-120

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CMYA5down-regulatesRREB1repressesR-22990.1607979Pr-120
TP53down-regulatesRREB1repressesR-22990.1607979Pr-120
t(11;14)up-regulatesTGIF1repressesR-25030.3336117Pr-120
RNASeq_FGFR3_Callup-regulatesTGIF1repressesR-25030.3336117Pr-120
t(4;14)up-regulatesTGIF1repressesR-25030.3336117Pr-120
t(11;14)_cytogeneticup-regulatesTGIF1repressesR-25030.3336117Pr-120
t(4;14)_cytogeneticup-regulatesTGIF1repressesR-25030.3336117Pr-120
AHNAK2down-regulatesELF4repressesR-2342-0.45121416Pr-120
PCDH10down-regulatesELF4repressesR-2342-0.45121416Pr-120
t(11;14)up-regulatesELF4repressesR-2342-0.45121416Pr-120
RNASeq_FGFR3_Callup-regulatesELF4repressesR-2342-0.45121416Pr-120
NEBdown-regulatesBCL6repressesR-5460.45957613Pr-120
t(11;14)up-regulatesBCL6repressesR-5460.45957613Pr-120
MYCdown-regulatesBCL6repressesR-5460.45957613Pr-120
del17down-regulatesBCL6repressesR-5460.45957613Pr-120
CMYA5down-regulatesNFATC1repressesR-2201-0.6870318Pr-120
DNAH5down-regulatesNFATC1repressesR-2201-0.6870318Pr-120
FAM46Cdown-regulatesNFATC1repressesR-2201-0.6870318Pr-120
IRF4up-regulatesNFATC1repressesR-2201-0.6870318Pr-120
t(11;14)up-regulatesNFATC1repressesR-2201-0.6870318Pr-120
RNASeq_CCND3_Callup-regulatesNFATC1repressesR-2201-0.6870318Pr-120
t(14;16)up-regulatesNFATC1repressesR-2201-0.6870318Pr-120
del13up-regulatesNFATC1repressesR-2201-0.6870318Pr-120
t(11;14)_cytogeneticup-regulatesNFATC1repressesR-2201-0.6870318Pr-120
t(11;14)down-regulatesARID3AactivatesR-13460.7257919Pr-120
t(11;14)up-regulatesENSG00000245848repressesR-16510.75457312Pr-120
MYCdown-regulatesENSG00000245848repressesR-16510.75457312Pr-120
del17down-regulatesENSG00000245848repressesR-16510.75457312Pr-120
t(11;14)down-regulatesFLI1activatesR-7920.8103357Pr-120
t(4;14)down-regulatesFLI1activatesR-7920.8103357Pr-120
TRAF3down-regulatesFLI1activatesR-7920.8103357Pr-120
del13down-regulatesFLI1activatesR-7920.8103357Pr-120
t(11;14)_cytogeneticdown-regulatesFLI1activatesR-7920.8103357Pr-120
ATMup-regulatesSMAD3repressesR-29631.446688Pr-120
DIS3up-regulatesSMAD3repressesR-29631.446688Pr-120
FAM46Cdown-regulatesSMAD3repressesR-29631.446688Pr-120
IRF4up-regulatesSMAD3repressesR-29631.446688Pr-120
NRASdown-regulatesSMAD3repressesR-29631.446688Pr-120
t(11;14)up-regulatesSMAD3repressesR-29631.446688Pr-120
RNASeq_FGFR3_Callup-regulatesSMAD3repressesR-29631.446688Pr-120
t(14;16)up-regulatesSMAD3repressesR-29631.446688Pr-120
t(4;14)up-regulatesSMAD3repressesR-29631.446688Pr-120
TRIOup-regulatesSMAD3repressesR-29631.446688Pr-120
t(11;14)_cytogeneticup-regulatesSMAD3repressesR-29631.446688Pr-120
t(4;14)_cytogeneticup-regulatesSMAD3repressesR-29631.446688Pr-120

Regulons in program Pr-120

Regulon Cox Hazard Ratio # genes # causal flows
R-22990.16079792
R-25030.33361175
R-2342-0.451214164
R-5460.459576134
R-2201-0.68703189
R-13460.72579191
R-16510.754573123
R-7920.81033575
R-29631.44668812

Genes in program Pr-120

EnsEMBL IdEntrez IdPreferred
ENSG00000176915 23141ANKLE2
ENSG00000178821 339456TMEM52
ENSG00000180667 55432YOD1
ENSG00000180855 10224ZNF443
ENSG00000184221
ENSG00000184661 157313CDCA2
ENSG00000184990 10572SIVA1
ENSG00000185627 5719PSMD13
ENSG00000198824 283489CHAMP1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions