Program

Causal Mechanistic Flows with regulons in program Pr-90

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_MAFA_Callup-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
t(14;16)up-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
t(4;14)up-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
amp1qup-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
del1pup-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
t(4;14)_cytogeneticup-regulatesSTAT5AactivatesR-2163-0.03362212Pr-90
t(14;16)up-regulatesRUNX3activatesR-895-0.10778613Pr-90
TP53up-regulatesRUNX3activatesR-895-0.10778613Pr-90
DSTup-regulatesENSG00000162367activatesR-1709-0.43212916Pr-90
del1pup-regulatesENSG00000162367activatesR-1709-0.43212916Pr-90
ATMup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
CSMD1up-regulatesSMAD3activatesR-2960-0.75971615Pr-90
DIS3up-regulatesSMAD3activatesR-2960-0.75971615Pr-90
FLGup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
NRASdown-regulatesSMAD3activatesR-2960-0.75971615Pr-90
RNASeq_MAFA_Callup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
RNASeq_MAFB_Callup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
t(14;16)up-regulatesSMAD3activatesR-2960-0.75971615Pr-90
t(4;14)up-regulatesSMAD3activatesR-2960-0.75971615Pr-90
SYNE2up-regulatesSMAD3activatesR-2960-0.75971615Pr-90
TRIOup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
amp1qup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
del1pup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
t(14;16)_cytogeneticup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
t(4;14)_cytogeneticup-regulatesSMAD3activatesR-2960-0.75971615Pr-90
RNASeq_MAFA_Callup-regulatesSTAT4activatesR-2651-0.8797413Pr-90
t(14;16)up-regulatesSTAT4activatesR-2651-0.8797413Pr-90
t(11;14)up-regulatesFOXP1activatesR-3130-0.94670722Pr-90
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-3130-0.94670722Pr-90
t(14;16)up-regulatesFOXP1activatesR-3130-0.94670722Pr-90
del1pup-regulatesFOXP1activatesR-3130-0.94670722Pr-90
CSMD1down-regulatesTCF3repressesR-2057-1.0953228Pr-90
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-2057-1.0953228Pr-90
t(14;16)down-regulatesTCF3repressesR-2057-1.0953228Pr-90
t(11;14)up-regulatesFOXJ2activatesR-1437-1.1465323Pr-90
t(14;16)up-regulatesFOXJ2activatesR-1437-1.1465323Pr-90
amp1qup-regulatesFOXJ2activatesR-1437-1.1465323Pr-90
NRASdown-regulatesNFIAactivatesR-3531.3079910Pr-90
RELNup-regulatesNFIAactivatesR-3531.3079910Pr-90
RNASeq_MAFA_Callup-regulatesNFIAactivatesR-3531.3079910Pr-90
RNASeq_MAFB_Callup-regulatesNFIAactivatesR-3531.3079910Pr-90
t(14;16)up-regulatesNFIAactivatesR-3531.3079910Pr-90
SYNE2up-regulatesNFIAactivatesR-3531.3079910Pr-90
WDFY3up-regulatesNFIAactivatesR-3531.3079910Pr-90
t(14;16)_cytogeneticup-regulatesNFIAactivatesR-3531.3079910Pr-90
MYCdown-regulatesBCL6activatesR-536-1.4118923Pr-90
FAT2up-regulatesETS1activatesR-3-1.5228415Pr-90
NRASdown-regulatesETS1activatesR-3-1.5228415Pr-90
RNASeq_MAFA_Callup-regulatesETS1activatesR-3-1.5228415Pr-90
RNASeq_MAFB_Callup-regulatesETS1activatesR-3-1.5228415Pr-90
t(14;16)up-regulatesETS1activatesR-3-1.5228415Pr-90
SYNE2up-regulatesETS1activatesR-3-1.5228415Pr-90
NRASdown-regulatesSTAT3activatesR-306-2.1502114Pr-90
t(14;16)up-regulatesSTAT3activatesR-306-2.1502114Pr-90
MYCdown-regulatesSTAT3activatesR-306-2.1502114Pr-90
t(4;14)up-regulatesSTAT3activatesR-306-2.1502114Pr-90
amp1qup-regulatesSTAT3activatesR-306-2.1502114Pr-90
t(11;14)_cytogeneticdown-regulatesSTAT3activatesR-306-2.1502114Pr-90
ATMup-regulatesSPIBactivatesR-668-2.4167716Pr-90
DIS3up-regulatesSPIBactivatesR-668-2.4167716Pr-90
FAM46Cdown-regulatesSPIBactivatesR-668-2.4167716Pr-90
NRASdown-regulatesSPIBactivatesR-668-2.4167716Pr-90
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-668-2.4167716Pr-90
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-668-2.4167716Pr-90
t(14;16)up-regulatesSPIBactivatesR-668-2.4167716Pr-90
TRIOup-regulatesSPIBactivatesR-668-2.4167716Pr-90
amp1qup-regulatesSPIBactivatesR-668-2.4167716Pr-90
del1pup-regulatesSPIBactivatesR-668-2.4167716Pr-90
FAT2up-regulatesENSG00000177374activatesR-2361-2.623212Pr-90
NRASdown-regulatesENSG00000177374activatesR-2361-2.623212Pr-90
t(11;14)down-regulatesENSG00000177374activatesR-2361-2.623212Pr-90
RNASeq_MAFA_Callup-regulatesENSG00000177374activatesR-2361-2.623212Pr-90
t(14;16)up-regulatesENSG00000177374activatesR-2361-2.623212Pr-90

Regulons in program Pr-90

Regulon Cox Hazard Ratio # genes # causal flows
R-2163-0.033622126
R-895-0.107786132
R-1709-0.432129162
R-2960-0.7597161515
R-2651-0.87974132
R-3130-0.946707224
R-2057-1.09532283
R-1437-1.14653233
R-3531.30799108
R-536-1.41189231
R-3-1.52284156
R-306-2.15021146
R-668-2.416771610
R-2361-2.6232125

Genes in program Pr-90

EnsEMBL IdEntrez IdPreferred
ENSG00000175592 8061FOSL1
ENSG00000176209 114926SMIM19
ENSG00000180233 223082ZNRF2
ENSG00000185024 2972BRF1
ENSG00000186480 3638INSIG1
ENSG00000187446 11261CHP1
ENSG00000196154 6275S100A4
ENSG00000196591 3066HDAC2
ENSG00000197937 84671ZNF347
ENSG00000198719
ENSG00000203778 619208FAM229B
ENSG00000243943 84450ZNF512
ENSG00000272414 100631383FAM47E-STBD1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions