Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.
NFIA - nuclear factor I A
Uniprot Browser| Entrez ID | EnsEMBL ID | Preferred Name | Uniprot ID |
|---|---|---|---|
| 4774 | ENSG00000162599 | NFIA | A0A590UK38 |
Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.
Causal Mechanistic Flows for Regulator: NFIA
| Mutation | Regulator | Role | Regulon | Cox Hazard Ratio | Transcriptional Program |
|---|---|---|---|---|---|
| RNASeq_MAFA_Call | NFIA | represses | R-356 | 0.286701 | Pr-129 |
| NRAS | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| RELN | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| RNASeq_MAFA_Call | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| RNASeq_MAFB_Call | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| t(14;16) | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| SYNE2 | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| WDFY3 | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| t(14;16)_cytogenetic | NFIA | activates | R-353 | 1.30799 | Pr-90 |
| DNAH5 | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| NRAS | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| RNASeq_MAFA_Call | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| t(14;16) | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| TP53 | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| t(14;16)_cytogenetic | NFIA | represses | R-354 | -2.9087 | Pr-60 |
| DNAH10 | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| NRAS | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| PRDM1 | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| RNASeq_FGFR3_Call | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| RNASeq_MAFA_Call | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| RNASeq_MAFB_Call | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| t(14;16) | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| TP53 | NFIA | activates | R-355 | 4.10051 | Pr-76 |
| t(14;16)_cytogenetic | NFIA | activates | R-355 | 4.10051 | Pr-76 |
Regulator Causal Mechanistic Flow Network
Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.
