Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation RNASeq_MAFA_Call

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
DR1up-regulatesR-45-0.00173773Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

NR2F6down-regulatesR-13820.010612Pr-41
STAT5Aup-regulatesR-2163-0.033622Pr-90
ENSG00000177374up-regulatesR-23600.0589228Pr-1
SMAD3up-regulatesR-2966-0.0660624Pr-85
SP1up-regulatesR-2717-0.0948824Pr-2
SREBF1up-regulatesR-11390.101608Pr-7
SP1up-regulatesR-27300.102205Pr-89
RREB1down-regulatesR-2304-0.103823Pr-135
ELF2down-regulatesR-9740.122498Pr-25
FLI1down-regulatesR-790-0.135687Pr-137
PLAG1down-regulatesR-15220.140759Pr-93
VBP1up-regulatesR-2104-0.154186Pr-2
E4F1down-regulatesR-3147-0.190868Pr-0
SPIBup-regulatesR-6620.193889Pr-1
SP1up-regulatesR-27140.199684Pr-109
HSF2down-regulatesR-3159-0.213586Pr-85
ETV5down-regulatesR-338-0.237093Pr-0
SOX4down-regulatesR-21870.253475Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

CEBPGdown-regulatesR-436-0.258645Pr-2
SPIBup-regulatesR-670-0.26844Pr-92
ZEB1up-regulatesR-22470.272353Pr-7
MAFKdown-regulatesR-28010.283548Pr-40
ETS1up-regulatesR-5-0.284036Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

NFIAup-regulatesR-3560.286701Pr-129
FOXJ3down-regulatesR-2876-0.290335Pr-3
ATF1up-regulatesR-5640.297759Pr-93
ARID5Aup-regulatesR-597-0.298346Pr-85
FOXK1down-regulatesR-1191-0.320198Pr-3
FOXO3down-regulatesR-2769-0.336939Pr-3
ENSG00000177374up-regulatesR-23640.342897Pr-139
FOXK1down-regulatesR-12000.353655Pr-128
FOXK1down-regulatesR-1192-0.353736Pr-0
TRAF4down-regulatesR-3043-0.355413Pr-4
CEBPGdown-regulatesR-4510.388628Pr-117
SPIBup-regulatesR-6610.39364Pr-85
ARID5Aup-regulatesR-596-0.400576Pr-1
NR2C2down-regulatesR-1389-0.401596Pr-92
TCF3down-regulatesR-20450.404713Pr-1
MLXup-regulatesR-3197-0.407624Pr-0
ZNF143up-regulatesR-23120.42534Pr-25
ETS1up-regulatesR-12-0.427939Pr-60
ZNF143up-regulatesR-2325-0.447293Pr-3
HINFPdown-regulatesR-2624-0.44835Pr-35
ELF2down-regulatesR-9690.451308Pr-13
MAFup-regulatesR-1020.468356Pr-88
RFX7down-regulatesR-27490.473078Pr-5
HINFPdown-regulatesR-2627-0.48712Pr-88
ENSG00000178860up-regulatesR-11020.509953Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

MEF2Adown-regulatesR-1866-0.518528Pr-3
FOXJ1up-regulatesR-18490.519757Pr-7
NFATC2up-regulatesR-16880.551677Pr-85
IRX3down-regulatesR-2234-0.576042Pr-88
ENSG00000135638down-regulatesR-19580.576875Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

ZNF143up-regulatesR-2309-0.580912Pr-2
FOXO1down-regulatesR-14110.58467Pr-60
TGIF1up-regulatesR-25010.587545Pr-122
FOXJ3down-regulatesR-2881-0.590232Pr-34
NR3C1up-regulatesR-31900.592808Pr-23
SMAD3up-regulatesR-2962-0.592902Pr-122
ENSG00000143995down-regulatesR-133-0.60449Pr-138
RREB1down-regulatesR-2283-0.618728Pr-2
ELK4up-regulatesR-7710.623476Pr-117
ARID3Aup-regulatesR-1341-0.641665Pr-2
HSF2down-regulatesR-31670.645152Pr-3
RREB1down-regulatesR-2300-0.646333Pr-20
ARID3Aup-regulatesR-1336-0.651462Pr-0
MYBup-regulatesR-6150.668149Pr-85
TFCP2up-regulatesR-1698-0.67238Pr-0
TCF3down-regulatesR-20650.686699Pr-7
KLF7down-regulatesR-287-0.699278Pr-28
FLI1down-regulatesR-786-0.733394Pr-59
TFCP2up-regulatesR-1699-0.734782Pr-3
MEF2Adown-regulatesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RREB1down-regulatesR-2296-0.757232Pr-9
SMAD3up-regulatesR-2960-0.759716Pr-90
SOX4down-regulatesR-2189-0.776926Pr-12
TRAF4down-regulatesR-3033-0.781484Pr-0
VBP1up-regulatesR-21000.788348Pr-0
SP1up-regulatesR-2711-0.793825Pr-0
IRX3down-regulatesR-22280.802821Pr-3
FOXO1down-regulatesR-1394-0.807027Pr-0
MAZup-regulatesR-508-0.810173Pr-0
STAT5Bup-regulatesR-23660.819111Pr-85
ETS1up-regulatesR-7-0.82093Pr-64
ELF2down-regulatesR-9820.82189Pr-21
FOXK1down-regulatesR-1188-0.824193Pr-0
XBP1down-regulatesR-3065-0.830078Pr-65
FOXP1up-regulatesR-31360.83863Pr-7
CDC5Lup-regulatesR-16300.87323Pr-1
TCF3down-regulatesR-2067-0.873555Pr-135
STAT4up-regulatesR-2651-0.87974Pr-90
ELK1up-regulatesR-6410.884722Pr-58
ETV3down-regulatesR-2538-0.885616Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

IRX3down-regulatesR-2220-0.898467Pr-0
ZNF691up-regulatesR-30080.909713Pr-62
ERFdown-regulatesR-3370.913173Pr-135
NR3C1up-regulatesR-31760.918992Pr-1
ETV3down-regulatesR-25310.919835Pr-136
ATF1up-regulatesR-559-0.936734Pr-0
BBXup-regulatesR-15320.944278Pr-16
FOXP1up-regulatesR-3130-0.946707Pr-90
SREBF1up-regulatesR-11370.963749Pr-87
NFYCup-regulatesR-299-0.964307Pr-111
ERFdown-regulatesR-3310.969151Pr-136
PAX5down-regulatesR-23740.983647Pr-85
PBX1down-regulatesR-2114-0.995452Pr-4
FOXJ3down-regulatesR-2870-0.999227Pr-0
ETV5down-regulatesR-3391.002Pr-136
NFATC1down-regulatesR-2207-1.00385Pr-15
IRX3down-regulatesR-2232-1.01367Pr-3
PBX1down-regulatesR-21121.03594Pr-3
STAT4up-regulatesR-26471.03676Pr-85
MAFKdown-regulatesR-28001.04701Pr-13
FOXJ3down-regulatesR-28831.05152Pr-5
MYBup-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ARID5Aup-regulatesR-6041.06015Pr-18
ETS1up-regulatesR-131.07999Pr-93
SP1up-regulatesR-27131.08118Pr-87
CEBPGdown-regulatesR-433-1.08132Pr-0
HMGA1down-regulatesR-8331.0818Pr-58
KLF7down-regulatesR-290-1.08997Pr-0
TCF3down-regulatesR-2057-1.09532Pr-90
HINFPdown-regulatesR-2625-1.11022Pr-118
RREB1down-regulatesR-2298-1.11227Pr-6
FOXP1up-regulatesR-31251.11357Pr-87
ELF2down-regulatesR-964-1.11857Pr-58
SP1up-regulatesR-2728-1.12023Pr-9
ATF1up-regulatesR-562-1.1286Pr-0
MAFKdown-regulatesR-2798-1.12983Pr-0
NFATC1down-regulatesR-22061.13365Pr-0
ESRRGdown-regulatesR-24351.13858Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXJ3down-regulatesR-2871-1.14551Pr-58
ARID3Aup-regulatesR-1344-1.15545Pr-9
NFATC1down-regulatesR-2204-1.15799Pr-10
ARID5Aup-regulatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

FOXP1up-regulatesR-31381.1619Pr-88
ARID3Aup-regulatesR-1353-1.16523Pr-10
TCF3down-regulatesR-2062-1.17031Pr-102
TCF3down-regulatesR-20521.17437Pr-87
ELF2down-regulatesR-9791.18484Pr-135
MAZup-regulatesR-503-1.19474Pr-9
DLX4down-regulatesR-1988-1.19988Pr-137
XBP1down-regulatesR-30671.20619Pr-7
FOXP1up-regulatesR-31311.21746Pr-93
PLAG1down-regulatesR-15171.22016Pr-108
FLI1down-regulatesR-7881.22051Pr-7
FOXO3down-regulatesR-2774-1.22358Pr-10
ERFdown-regulatesR-333-1.22378Pr-3
TRAF4down-regulatesR-3036-1.23044Pr-112
HMGA1down-regulatesR-8261.24266Pr-93
MEF2Adown-regulatesR-1878-1.24921Pr-9
SPIBup-regulatesR-6661.25766Pr-16
NR2C2down-regulatesR-1392-1.2713Pr-60
MAFKdown-regulatesR-2806-1.27994Pr-9
ZNF143up-regulatesR-2316-1.2845Pr-22
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

FOXP1up-regulatesR-31281.29587Pr-16
NFIAup-regulatesR-3531.30799Pr-90
ETS1up-regulatesR-101.31637Pr-109
KLF13down-regulatesR-2041-1.31925Pr-42
SPIBup-regulatesR-6641.32468Pr-87
CEBPGdown-regulatesR-448-1.37561Pr-10
SP1up-regulatesR-27251.37906Pr-93
ETS1up-regulatesR-81.3888Pr-96
ZNF691up-regulatesR-30091.394Pr-139
FOXO1down-regulatesR-1408-1.42694Pr-9
MAFKdown-regulatesR-28101.44186Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

NR3C1up-regulatesR-3193-1.45371Pr-86
FOXJ3down-regulatesR-2892-1.46097Pr-10
FOXK1down-regulatesR-1205-1.46171Pr-10
MAFup-regulatesR-1041.49044Pr-88
MZF1down-regulatesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

ELF2down-regulatesR-977-1.49682Pr-85
ETS1up-regulatesR-3-1.52284Pr-90
MZF1down-regulatesR-30171.54275Pr-85
MAFup-regulatesR-1011.56978Pr-87
ZNF143up-regulatesR-2322-1.59054Pr-3
HMGA1down-regulatesR-8221.59236Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

MAFKdown-regulatesR-2802-1.60272Pr-25
NFATC2up-regulatesR-1690-1.61477Pr-88
MYBup-regulatesR-6171.6152Pr-87
MYBup-regulatesR-6231.65419Pr-96
SREBF1up-regulatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

VBP1up-regulatesR-21021.67538Pr-73
MZF1down-regulatesR-3025-1.67565Pr-11
FOXJ3down-regulatesR-2894-1.67584Pr-113
ZEB1up-regulatesR-22491.69836Pr-1
RFX7down-regulatesR-2750-1.73199Pr-118
ZEB1up-regulatesR-2240-1.75042Pr-86
MAZup-regulatesR-511-1.75904Pr-0
FOXO1down-regulatesR-14091.77972Pr-21
FOXK1down-regulatesR-1206-1.77991Pr-88
HMGA1down-regulatesR-8201.79517Pr-87
ATF1up-regulatesR-560-1.81953Pr-4
MAZup-regulatesR-4951.8487Pr-87
TRIM28down-regulatesR-1503-1.87101Pr-42
E2F2up-regulatesR-29451.88745Pr-133
SATB1down-regulatesR-1075-1.88885Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

NFYCup-regulatesR-293-1.90832Pr-4
MYBup-regulatesR-622-1.933Pr-85
RREB1down-regulatesR-2302-1.95334Pr-10
ENSG00000175745down-regulatesR-5141.95404Pr-123
FOXO1down-regulatesR-1412-1.97656Pr-28
HMGA1down-regulatesR-824-1.97932Pr-91
SOX4down-regulatesR-2185-1.98014Pr-0
ZNF740down-regulatesR-3841.98118Pr-52
SMAD3up-regulatesR-2967-1.98807Pr-139
PLAG1down-regulatesR-1521-2.02883Pr-118
YY1up-regulatesR-2526-2.05153Pr-89
NR3C1up-regulatesR-31792.06628Pr-60
STAT4up-regulatesR-2649-2.07524Pr-86
ETV3down-regulatesR-2532-2.0819Pr-3
ELK1up-regulatesR-6492.08583Pr-96
BBXup-regulatesR-1537-2.08705Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

MEF2Adown-regulatesR-1885-2.09865Pr-89
PLAG1down-regulatesR-1525-2.09931Pr-42
HINFPdown-regulatesR-2623-2.10028Pr-110
TCF3down-regulatesR-2056-2.11546Pr-91
NR3C1up-regulatesR-3195-2.141Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

VBP1up-regulatesR-2099-2.16715Pr-4
SPIBup-regulatesR-672-2.17589Pr-135
ENSG00000175745down-regulatesR-5152.17763Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

SP1up-regulatesR-2733-2.20943Pr-20
ARID3Aup-regulatesR-1348-2.22043Pr-137
ARID3Aup-regulatesR-13382.23222Pr-60
XBP1down-regulatesR-3058-2.24563Pr-59
ZNF740down-regulatesR-397-2.24578Pr-139
ENSG00000136574down-regulatesR-36-2.24791Pr-15
STAT5Aup-regulatesR-2159-2.25001Pr-86
SRFdown-regulatesR-1778-2.26549Pr-4
YY1up-regulatesR-25222.27836Pr-16
YY1up-regulatesR-2523-2.28203Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

SMAD3up-regulatesR-29652.28284Pr-137
MZF1down-regulatesR-30212.2875Pr-87
HINFPdown-regulatesR-2628-2.29875Pr-42
RELAdown-regulatesR-1463-2.30399Pr-4
HMGA1down-regulatesR-8342.30843Pr-136
NR2C2down-regulatesR-13872.31271Pr-131
HMGA1down-regulatesR-818-2.31588Pr-4
MZF1down-regulatesR-3022-2.32297Pr-139
ELF2down-regulatesR-987-2.34496Pr-20
NR3C1up-regulatesR-3187-2.36326Pr-85
ENSG00000087510up-regulatesR-2630-2.36566Pr-93
XBP1down-regulatesR-3056-2.38499Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

SP1up-regulatesR-2723-2.38863Pr-30
MEF2Adown-regulatesR-18812.39457Pr-21
ELF2down-regulatesR-9762.40613Pr-62
MAFKdown-regulatesR-2799-2.41258Pr-4
SPIBup-regulatesR-668-2.41677Pr-90
IRX3down-regulatesR-22292.44878Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ERFdown-regulatesR-3352.46806Pr-136
ARID5Aup-regulatesR-598-2.47726Pr-17
FOXO3down-regulatesR-2767-2.51658Pr-4
FLI1down-regulatesR-7932.52326Pr-96
CEBPGdown-regulatesR-4452.53867Pr-21
ERFdown-regulatesR-329-2.5417Pr-36
ZNF691up-regulatesR-3010-2.54571Pr-3