Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-45

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
DIS3	up-regulates	TGIF1	represses	R-2504	-0.811771	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)	up-regulates	TGIF1	represses	R-2504	-0.811771	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
RNASeq_CCND3_Call	up-regulates	TGIF1	represses	R-2504	-0.811771	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)	up-regulates	TGIF1	represses	R-2504	-0.811771	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)_cytogenetic	up-regulates	TGIF1	represses	R-2504	-0.811771	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
HUWE1	up-regulates	HSF4	represses	R-174	-1.34961	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
IRF4	up-regulates	HSF4	represses	R-174	-1.34961	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)	up-regulates	HSF4	represses	R-174	-1.34961	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)_cytogenetic	up-regulates	HSF4	represses	R-174	-1.34961	6	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
HUWE1	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
IRF4	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
KDM3B	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
MXRA5	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
PRKD2	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
RNASeq_MAFA_Call	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
ROBO2	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)_cytogenetic	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)_cytogenetic	down-regulates	HOXA5	activates	R-25	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
AHNAK2	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
FRAS1	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
HUWE1	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
IRF4	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
KDM3B	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
RNASeq_MAFA_Call	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
MYC	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(4;14)	up-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
amp1q	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(11;14)_cytogenetic	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)_cytogenetic	down-regulates	ENSG00000105991	activates	R-229	-2.84707	7	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
DST	up-regulates	ENSG00000186564	represses	R-481	-3.30778	9	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
t(14;16)	up-regulates	ENSG00000186564	represses	R-481	-3.30778	9	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
TRAF3	up-regulates	ENSG00000186564	represses	R-481	-3.30778	9	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481

Regulons in program Pr-45

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-2504	-0.811771	6	5
R-174	-1.34961	6	4
R-25	-2.84707	7	11
R-229	-2.84707	7	13
R-481	-3.30778	9	3

Genes in program Pr-45

EnsEMBL Id	Entrez Id	Preferred
ENSG00000185633	56901	NDUFA4L2
ENSG00000198276	54963	UCKL1

Pr-45

Program 45

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Program Survival Plots