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Causal Mechanistic Flows with regulons in program Pr-17

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Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
AHNAK2	down-regulates	SPDEF	activates	R-1961	-1.74175	16	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	FOXP1	activates	R-3124	-2.15985	30	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	TRAF4	activates	R-3035	-2.1684	17	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	FOXK1	activates	R-1194	-2.1796	24	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	RREB1	activates	R-2286	-2.31249	19	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	NR4A2	activates	R-1716	-2.35911	11	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	FOXO1	activates	R-1399	-2.38797	30	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	HBP1	activates	R-1829	-2.78136	20	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	ELF4	activates	R-2330	-2.93229	34	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
AHNAK2	down-regulates	RELA	activates	R-1465	-3.41018	8	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997

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Regulons in program Pr-17

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Regulon	Cox Hazard Ratio	# genes	# causal flows
R-3124	-2.15985	30	9
R-3035	-2.1684	17	7
R-2997	-4.26614	15	4
R-2330	-2.93229	34	4
R-2286	-2.31249	19	6
R-1961	-1.74175	16	4
R-1829	-2.78136	20	7
R-1716	-2.35911	11	6
R-1465	-3.41018	8	7
R-1399	-2.38797	30	4

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Genes in program Pr-17

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EnsEMBL Id	Entrez Id	Preferred
ENSG00000213551	23234	DNAJC9
ENSG00000230510	100506012	PPP5D1
ENSG00000239305	7844	RNF103
ENSG00000244005	9054	NFS1
ENSG00000244242	402778	IFITM10
ENSG00000247315	85364	ZCCHC3
ENSG00000256269	3145	HMBS
ENSG00000257923	1523	CUX1
ENSG00000259120	100130933	SMIM6
ENSG00000262246	79585	CORO7

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