Program

Causal Mechanistic Flows with regulons in program Pr-17

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesSPDEFactivatesR-1961-1.7417516Pr-17
CYLDup-regulatesSPDEFactivatesR-1961-1.7417516Pr-17
amp1qup-regulatesSPDEFactivatesR-1961-1.7417516Pr-17
del13up-regulatesSPDEFactivatesR-1961-1.7417516Pr-17
HUWE1up-regulatesZNF740repressesR-385-2.0049711Pr-17
t(14;16)down-regulatesZNF740repressesR-385-2.0049711Pr-17
amp1qdown-regulatesZNF740repressesR-385-2.0049711Pr-17
del13down-regulatesZNF740repressesR-385-2.0049711Pr-17
LRP2down-regulatesENSG00000054598activatesR-1001-2.0621931Pr-17
AHNAK2down-regulatesFOXP1activatesR-3124-2.1598530Pr-17
CYLDup-regulatesFOXP1activatesR-3124-2.1598530Pr-17
PCDH10down-regulatesFOXP1activatesR-3124-2.1598530Pr-17
PRDM1up-regulatesFOXP1activatesR-3124-2.1598530Pr-17
RNASeq_CCND2_Calldown-regulatesFOXP1activatesR-3124-2.1598530Pr-17
t(14;16)up-regulatesFOXP1activatesR-3124-2.1598530Pr-17
amp1qup-regulatesFOXP1activatesR-3124-2.1598530Pr-17
del13up-regulatesFOXP1activatesR-3124-2.1598530Pr-17
del1pup-regulatesFOXP1activatesR-3124-2.1598530Pr-17
AHNAK2down-regulatesTRAF4activatesR-3035-2.168417Pr-17
CMYA5down-regulatesTRAF4activatesR-3035-2.168417Pr-17
CYLDup-regulatesTRAF4activatesR-3035-2.168417Pr-17
FAT3down-regulatesTRAF4activatesR-3035-2.168417Pr-17
PCDH10down-regulatesTRAF4activatesR-3035-2.168417Pr-17
RNASeq_CCND2_Calldown-regulatesTRAF4activatesR-3035-2.168417Pr-17
TACC2down-regulatesTRAF4activatesR-3035-2.168417Pr-17
AHNAK2down-regulatesFOXK1activatesR-1194-2.179624Pr-17
FAT3down-regulatesFOXK1activatesR-1194-2.179624Pr-17
amp1qup-regulatesFOXK1activatesR-1194-2.179624Pr-17
del13up-regulatesFOXK1activatesR-1194-2.179624Pr-17
AHNAK2down-regulatesRREB1activatesR-2286-2.3124919Pr-17
CMYA5down-regulatesRREB1activatesR-2286-2.3124919Pr-17
FAT3down-regulatesRREB1activatesR-2286-2.3124919Pr-17
MXRA5down-regulatesRREB1activatesR-2286-2.3124919Pr-17
TACC2down-regulatesRREB1activatesR-2286-2.3124919Pr-17
TP53down-regulatesRREB1activatesR-2286-2.3124919Pr-17
AHNAK2down-regulatesNR4A2activatesR-1716-2.3591111Pr-17
CMYA5down-regulatesNR4A2activatesR-1716-2.3591111Pr-17
CYLDup-regulatesNR4A2activatesR-1716-2.3591111Pr-17
FAT3down-regulatesNR4A2activatesR-1716-2.3591111Pr-17
MXRA5down-regulatesNR4A2activatesR-1716-2.3591111Pr-17
TP53down-regulatesNR4A2activatesR-1716-2.3591111Pr-17
AHNAK2down-regulatesFOXO1activatesR-1399-2.3879730Pr-17
FAT3down-regulatesFOXO1activatesR-1399-2.3879730Pr-17
TACC2down-regulatesFOXO1activatesR-1399-2.3879730Pr-17
del13up-regulatesFOXO1activatesR-1399-2.3879730Pr-17
RNASeq_MAFA_Callup-regulatesARID5AactivatesR-598-2.4772616Pr-17
t(14;16)up-regulatesARID5AactivatesR-598-2.4772616Pr-17
amp1qup-regulatesARID5AactivatesR-598-2.4772616Pr-17
del13up-regulatesARID5AactivatesR-598-2.4772616Pr-17
del1pup-regulatesARID5AactivatesR-598-2.4772616Pr-17
AHNAK2down-regulatesHBP1activatesR-1829-2.7813620Pr-17
DNAH5down-regulatesHBP1activatesR-1829-2.7813620Pr-17
FAT3down-regulatesHBP1activatesR-1829-2.7813620Pr-17
PCDH10down-regulatesHBP1activatesR-1829-2.7813620Pr-17
TACC2down-regulatesHBP1activatesR-1829-2.7813620Pr-17
amp1qup-regulatesHBP1activatesR-1829-2.7813620Pr-17
del13up-regulatesHBP1activatesR-1829-2.7813620Pr-17
AHNAK2down-regulatesELF4activatesR-2330-2.9322934Pr-17
PCDH10down-regulatesELF4activatesR-2330-2.9322934Pr-17
PRDM1up-regulatesELF4activatesR-2330-2.9322934Pr-17
t(14;16)up-regulatesELF4activatesR-2330-2.9322934Pr-17
DNAH5down-regulatesJDP2activatesR-358-3.1026213Pr-17
FAT3down-regulatesJDP2activatesR-358-3.1026213Pr-17
LRP2down-regulatesJDP2activatesR-358-3.1026213Pr-17
NRASdown-regulatesJDP2activatesR-358-3.1026213Pr-17
RNASeq_FGFR3_Calldown-regulatesJDP2activatesR-358-3.1026213Pr-17
RNASeq_MAFA_Callup-regulatesJDP2activatesR-358-3.1026213Pr-17
t(14;16)up-regulatesJDP2activatesR-358-3.1026213Pr-17
t(4;14)down-regulatesJDP2activatesR-358-3.1026213Pr-17
AHNAK2down-regulatesRELAactivatesR-1465-3.410188Pr-17
DNAH5down-regulatesRELAactivatesR-1465-3.410188Pr-17
FAT3down-regulatesRELAactivatesR-1465-3.410188Pr-17
MACF1down-regulatesRELAactivatesR-1465-3.410188Pr-17
TACC2down-regulatesRELAactivatesR-1465-3.410188Pr-17
amp1qup-regulatesRELAactivatesR-1465-3.410188Pr-17
del13up-regulatesRELAactivatesR-1465-3.410188Pr-17
AHNAK2down-regulatesBACH1activatesR-470-3.7784313Pr-17
CMYA5down-regulatesBACH1activatesR-470-3.7784313Pr-17
PCDH10down-regulatesBACH1activatesR-470-3.7784313Pr-17
t(14;16)up-regulatesBACH1activatesR-470-3.7784313Pr-17
TACC2down-regulatesBACH1activatesR-470-3.7784313Pr-17
del13up-regulatesBACH1activatesR-470-3.7784313Pr-17
CMYA5down-regulatesTCF4activatesR-2997-4.2661415Pr-17
NRASdown-regulatesTCF4activatesR-2997-4.2661415Pr-17
TRAF3up-regulatesTCF4activatesR-2997-4.2661415Pr-17
del13up-regulatesTCF4activatesR-2997-4.2661415Pr-17

Regulons in program Pr-17

Regulon Cox Hazard Ratio # genes # causal flows
R-1961-1.74175164
R-385-2.00497114
R-1001-2.06219311
R-3124-2.15985309
R-3035-2.1684177
R-1194-2.1796244
R-2286-2.31249196
R-1716-2.35911116
R-1399-2.38797304
R-598-2.47726165
R-1829-2.78136207
R-2330-2.93229344
R-358-3.10262138
R-1465-3.4101887
R-470-3.77843136
R-2997-4.26614154

Genes in program Pr-17

EnsEMBL IdEntrez IdPreferred
ENSG00000213551 23234DNAJC9
ENSG00000230510 100506012PPP5D1
ENSG00000239305 7844RNF103
ENSG00000244005 9054NFS1
ENSG00000244242 402778IFITM10
ENSG00000247315 85364ZCCHC3
ENSG00000256269 3145HMBS
ENSG00000259120 100130933SMIM6
ENSG00000262246 79585CORO7
ENSG00000257923 1523CUX1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions