Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SPDEF - SAM pointed domain containing ETS transcription factor

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
25803 ENSG00000124664 SPDEF O95238

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: SPDEF

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2SPDEFactivatesR-19620.33001Pr-124
IRF4SPDEFrepressesR-1972-0.517954Pr-109
t(11;14)SPDEFrepressesR-1972-0.517954Pr-109
SETD2SPDEFrepressesR-1972-0.517954Pr-109
AHNAK2SPDEFactivatesR-1960-0.548684Pr-3
MAGI1SPDEFactivatesR-1960-0.548684Pr-3
PTPRDSPDEFactivatesR-1960-0.548684Pr-3
RNASeq_MAFB_CallSPDEFactivatesR-1960-0.548684Pr-3
del17pSPDEFactivatesR-1960-0.548684Pr-3
CYLDSPDEFactivatesR-1977-1.08293Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

IRF4SPDEFactivatesR-1977-1.08293Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qSPDEFactivatesR-1977-1.08293Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

del13SPDEFactivatesR-1977-1.08293Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

amp1qSPDEFactivatesR-19681.12309Pr-7
del13SPDEFactivatesR-19681.12309Pr-7
MAGI1SPDEFactivatesR-19591.15903Pr-1
amp1qSPDEFactivatesR-19591.15903Pr-1
del13SPDEFactivatesR-19591.15903Pr-1
amp1qSPDEFactivatesR-19751.56683Pr-125
del13SPDEFactivatesR-19751.56683Pr-125
IRF4SPDEFrepressesR-19741.59808Pr-63
t(11;14)SPDEFrepressesR-19741.59808Pr-63
TP53SPDEFrepressesR-19741.59808Pr-63
amp1qSPDEFrepressesR-19741.59808Pr-63
del13SPDEFrepressesR-19741.59808Pr-63
AHNAK2SPDEFactivatesR-1976-1.62216Pr-10
TP53SPDEFactivatesR-1976-1.62216Pr-10
AHNAK2SPDEFactivatesR-1961-1.74175Pr-17
CYLDSPDEFactivatesR-1961-1.74175Pr-17
amp1qSPDEFactivatesR-1961-1.74175Pr-17
del13SPDEFactivatesR-1961-1.74175Pr-17
IRF4SPDEFrepressesR-19641.96106Pr-127
t(11;14)SPDEFrepressesR-19641.96106Pr-127
SETD2SPDEFrepressesR-19641.96106Pr-127
TP53SPDEFrepressesR-19641.96106Pr-127
ZFHX3SPDEFrepressesR-19641.96106Pr-127
AHNAK2SPDEFactivatesR-1967-2.26981Pr-19
CYLDSPDEFactivatesR-1967-2.26981Pr-19
IRF4SPDEFactivatesR-1967-2.26981Pr-19
MAGI1SPDEFactivatesR-1967-2.26981Pr-19
PTPRDSPDEFactivatesR-1967-2.26981Pr-19
t(11;14)SPDEFactivatesR-1967-2.26981Pr-19
RNASeq_MAFB_CallSPDEFactivatesR-1967-2.26981Pr-19
ZFHX3SPDEFactivatesR-1967-2.26981Pr-19
IRF4SPDEFrepressesR-1969-2.53849Pr-65
t(11;14)SPDEFrepressesR-1969-2.53849Pr-65
amp1qSPDEFrepressesR-1969-2.53849Pr-65
del13SPDEFrepressesR-1969-2.53849Pr-65
AHNAK2SPDEFactivatesR-1966-2.98845Pr-11
t(11;14)SPDEFactivatesR-1966-2.98845Pr-11
TP53SPDEFactivatesR-1966-2.98845Pr-11
amp1qSPDEFactivatesR-1966-2.98845Pr-11
del13SPDEFactivatesR-1966-2.98845Pr-11
AHNAK2SPDEFrepressesR-19733.49659Pr-50
IRF4SPDEFrepressesR-19733.49659Pr-50
PTPRDSPDEFrepressesR-19733.49659Pr-50
RNASeq_MAFB_CallSPDEFrepressesR-19733.49659Pr-50
PTPRDSPDEFactivatesR-1970-3.58682Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(11;14)SPDEFactivatesR-1970-3.58682Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

PTPRDSPDEFactivatesR-1971-3.6364Pr-113
t(11;14)SPDEFactivatesR-1971-3.6364Pr-113
RNASeq_MAFB_CallSPDEFactivatesR-1971-3.6364Pr-113
amp1qSPDEFactivatesR-1971-3.6364Pr-113
del13SPDEFactivatesR-1971-3.6364Pr-113
AHNAK2SPDEFactivatesR-1963-4.23229Pr-35
IRF4SPDEFactivatesR-1963-4.23229Pr-35
t(11;14)SPDEFactivatesR-1963-4.23229Pr-35
RNASeq_MAFB_CallSPDEFactivatesR-1963-4.23229Pr-35
SETD2SPDEFactivatesR-1963-4.23229Pr-35
AHNAK2SPDEFrepressesR-19655.28567Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

PTPRDSPDEFrepressesR-19655.28567Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_MAFB_CallSPDEFrepressesR-19655.28567Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.