Mutation – Multiple Myeloma Network Portal

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TP53

Regulator	Role	Regulon	Cox Hazard Ratio (Regulon)	Transcriptional Programs
STAT1	up-regulates	R-3071	-0.0145432	Pr-133 Genes (6) UCP3, GJD4, ACOT4, HNRNPA0, ZCWPW2 Regulons (7) R-3071, R-1940, R-2231, R-372, R-2200, R-2945, R-2989
STAT3	down-regulates	R-311	-0.0731142	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
RREB1	down-regulates	R-2304	-0.103823	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
ATF3	down-regulates	R-2412	-0.107523	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
RUNX3	up-regulates	R-895	-0.107786	Pr-90 Genes (13) FOSL1, SMIM19, ZNRF2, BRF1, INSIG1, CHP1, S100A4, HDAC2, ZNF347, FAM229B, ZNF512, FAM47E-STBD1 Regulons (14) R-2163, R-895, R-1709, R-2960, R-2651, R-3130, R-2057, R-1437, R-353, R-536, R-3, R-306, R-668, R-2361
ATF3	down-regulates	R-2410	-0.14054	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
RREB1	down-regulates	R-2299	0.160797	Pr-120 Genes (9) ANKLE2, TMEM52, YOD1, ZNF443, CDCA2, SIVA1, PSMD13, CHAMP1 Regulons (9) R-2299, R-2503, R-2342, R-546, R-2201, R-1346, R-1651, R-792, R-2963
THRA	down-regulates	R-62	0.204827	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
NF1	down-regulates	R-127	-0.22305	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
IRF7	up-regulates	R-1086	-0.243887	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
ATF3	down-regulates	R-2409	-0.31315	Pr-0 Genes (84) GPX2, BNIP3, METRNL, PUS1, SAMD12, CD163, SLC25A20, EFCAB13, EXOSC4, SAMD4B, CATSPERE, C14orf119, ARHGAP45, BBS12, EHMT1, SETD2, ZBTB20, RFX7, TSKU, SRPRA, SLC25A10, ASB7, UPP1, LIN9, CCR10, ZFP1, USP18, TNFAIP2, CDNF, SOCS1, METTL7A, PDE6G, SP1, P4HB, DRG1, CXorf38, MORF4L1, AIDA, WWOX, SAPCD2, PPP1CC, SPIN4, CXCR3, ZNF397, TPCN1, CMC1, GCNT1, FNBP1, RSBN1L, LOC100288637, TMPPE, ZC3H6, ZNF669, NANOS1, ALKBH2, JPT1, LIN54, HLA-DRB1, ZNF493, EPHB4, TRAPPC2B, SIAH1, ESRRG, TCF4, SERTAD1, ZNF398, ZNF257, ATG7, MPEG1, RPS4X, PNP, HMGN2, HIST2H2BF, COLQ, RPS29 Regulons (86) R-180, R-2076, R-2157, R-3164, R-3147, R-338, R-2156, R-2409, R-885, R-941, R-1192, R-556, R-3197, R-1572, R-999, R-636, R-902, R-2541, R-440, R-890, R-3175, R-767, R-1542, R-1336, R-2472, R-1698, R-2326, R-1906, R-269, R-772, R-647, R-3033, R-2100, R-2711, R-1394, R-3068, R-508, R-63, R-1916, R-1188, R-532, R-2135, R-997, R-1687, R-2951, R-1853, R-2220, R-577, R-585, R-2597, R-1021, R-3119, R-301, R-559, R-1560, R-175, R-2870, R-3015, R-66, R-595, R-3185, R-2905, R-433, R-290, R-381, R-2509, R-562, R-2798, R-2206, R-1418, R-60, R-3050, R-2073, R-611, R-2488, R-881, R-1095, R-2153, R-2553, R-2305, R-2656, R-1697, R-511, R-2185, R-1492, R-2555
TFE3	down-regulates	R-558	-0.31956	Pr-39 Genes (11) PAAF1, KDF1, CD28, MAF, TBK1, PGP, FCAR, APOL6, SIGLEC14, MTRNR2L2 Regulons (17) R-889, R-2846, R-1954, R-558, R-2141, R-1857, R-708, R-378, R-1343, R-2900, R-1704, R-2347, R-2988, R-2552, R-1245, R-474, R-2797
ZFX	down-regulates	R-1927	-0.36742	Pr-5 Genes (32) ZNF25, POLD4, CLK2, EPS8L2, PIDD1, JUN, AGTRAP, C2orf69, GRINA, PTPN11, PITPNB, DNAH14, C15orf41, KIF18B, DUSP28, CFAP126, ZFP62, MYO5A, FAM114A1, FAM118B, PIM3, ZNF627, TEX45, ITPRIPL1, MRPL53, TECPR1, RNPS1, CFAP44, ZNF726, EML6, LOC441155 Regulons (33) R-362, R-1924, R-1337, R-92, R-1207, R-3137, R-2527, R-2775, R-2562, R-1927, R-2749, R-2109, R-1198, R-1854, R-275, R-2883, R-3016, R-286, R-1350, R-2038, R-148, R-42, R-3198, R-2569, R-2282, R-581, R-590, R-2346, R-2265, R-2473, R-2377, R-2110, R-1385
RREB1	down-regulates	R-2284	-0.436433	Pr-14 Genes (17) TMEM70, TUBB6, PNMA1, CASKIN2, ANXA2R, MLF1, ARID3B, SLC17A8, FZD2, PLAG1, SLC8A1, SEMA4B, NOXA1, AKR1C3, MPV17L2 Regulons (18) R-1002, R-1429, R-1659, R-894, R-77, R-1832, R-1545, R-184, R-2284, R-2223, R-2075, R-2878, R-2606, R-1398, R-2952, R-1932, R-3170, R-2014
JUN	down-regulates	R-1177	0.50809	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
E2F2	up-regulates	R-2943	-0.530398	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
THRA	down-regulates	R-59	-0.644538	Pr-30 Genes (6) HMCES, CHSY3, DNASE1, MC1R, PCDHGA4, LUZP6 Regulons (6) R-59, R-2407, R-2315, R-2482, R-2723, R-2957
ELF3	down-regulates	R-2141	-0.655011	Pr-39 Genes (11) PAAF1, KDF1, CD28, MAF, TBK1, PGP, FCAR, APOL6, SIGLEC14, MTRNR2L2 Regulons (17) R-889, R-2846, R-1954, R-558, R-2141, R-1857, R-708, R-378, R-1343, R-2900, R-1704, R-2347, R-2988, R-2552, R-1245, R-474, R-2797
IRF7	up-regulates	R-1083	0.674001	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
JUN	down-regulates	R-1186	0.700789	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
STAT1	up-regulates	R-3069	0.785822	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
VBP1	up-regulates	R-2100	0.788348	Pr-0 Genes (84) GPX2, BNIP3, METRNL, PUS1, SAMD12, CD163, SLC25A20, EFCAB13, EXOSC4, SAMD4B, CATSPERE, C14orf119, ARHGAP45, BBS12, EHMT1, SETD2, ZBTB20, RFX7, TSKU, SRPRA, SLC25A10, ASB7, UPP1, LIN9, CCR10, ZFP1, USP18, TNFAIP2, CDNF, SOCS1, METTL7A, PDE6G, SP1, P4HB, DRG1, CXorf38, MORF4L1, AIDA, WWOX, SAPCD2, PPP1CC, SPIN4, CXCR3, ZNF397, TPCN1, CMC1, GCNT1, FNBP1, RSBN1L, LOC100288637, TMPPE, ZC3H6, ZNF669, NANOS1, ALKBH2, JPT1, LIN54, HLA-DRB1, ZNF493, EPHB4, TRAPPC2B, SIAH1, ESRRG, TCF4, SERTAD1, ZNF398, ZNF257, ATG7, MPEG1, RPS4X, PNP, HMGN2, HIST2H2BF, COLQ, RPS29 Regulons (86) R-180, R-2076, R-2157, R-3164, R-3147, R-338, R-2156, R-2409, R-885, R-941, R-1192, R-556, R-3197, R-1572, R-999, R-636, R-902, R-2541, R-440, R-890, R-3175, R-767, R-1542, R-1336, R-2472, R-1698, R-2326, R-1906, R-269, R-772, R-647, R-3033, R-2100, R-2711, R-1394, R-3068, R-508, R-63, R-1916, R-1188, R-532, R-2135, R-997, R-1687, R-2951, R-1853, R-2220, R-577, R-585, R-2597, R-1021, R-3119, R-301, R-559, R-1560, R-175, R-2870, R-3015, R-66, R-595, R-3185, R-2905, R-433, R-290, R-381, R-2509, R-562, R-2798, R-2206, R-1418, R-60, R-3050, R-2073, R-611, R-2488, R-881, R-1095, R-2153, R-2553, R-2305, R-2656, R-1697, R-511, R-2185, R-1492, R-2555
ELF3	down-regulates	R-2151	-0.794443	Pr-22 Genes (9) TMEM179B, GPRIN3, LMNTD2, ZNF780A, MAFK, COX20, FANCG, ZNF737, PPIL3 Regulons (9) R-2350, R-2151, R-2186, R-2316, R-1888, R-876, R-2765, R-1678, R-1015
BBX	down-regulates	R-1536	-0.809151	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
ZNF691	up-regulates	R-3007	-0.816485	Pr-2 Genes (47) MSRA, PLEKHF2, NUPR1, IP6K1, TCP11L1, SPHK1, TYMS, FAM89B, WDR73, IRX3, ACAD9, CD151, KCNJ10, ARL6IP6, ODF3B, MPI, HYI, SPTY2D1, DAND5, ELMOD2, CDC42EP4, MAF1, SERTAD2, GLIPR1L2, LSMEM1, HIST3H2A, C5orf24, GINS3, RAD51B, MXRA7, BRICD5, RUVBL2, RBM12B, BRWD1, ANKRD37, TTC30B, SFI1, CTR9, CCDC167, PDXP Regulons (47) R-1855, R-2267, R-3037, R-486, R-2717, R-878, R-363, R-2104, R-631, R-3178, R-563, R-1911, R-436, R-183, R-2977, R-78, R-2479, R-2411, R-1825, R-49, R-272, R-390, R-1869, R-1831, R-2225, R-1586, R-775, R-535, R-1660, R-796, R-1574, R-1561, R-3126, R-2309, R-1717, R-2283, R-1341, R-2662, R-3007, R-2873, R-599, R-1189, R-2486, R-24, R-3064, R-570, R-288
IRF9	up-regulates	R-1149	0.851839	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
IRF7	up-regulates	R-1084	-0.861526	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
RREB1	down-regulates	R-2293	-0.862205	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
IRF1	up-regulates	R-182	0.909345	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
ZNF691	up-regulates	R-3008	0.909713	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
JUN	down-regulates	R-1181	0.916484	Pr-119 Genes (4) GPBAR1, RHD, GMFB, C5AR1 Regulons (4) R-832, R-1181, R-58, R-164
JUN	down-regulates	R-1184	-0.962738	Pr-66 Genes (3) SHISAL2A, USP7, RUNDC1 Regulons (3) R-2776, R-1184, R-825
ENSG00000165066	up-regulates	R-3080	0.967824	Pr-131 Genes (6) UBE2G2, ERC2, SLC9A8, ZNF770, MGEA5, ZNF350 Regulons (6) R-2999, R-3080, R-706, R-1303, R-79, R-1387
IRF7	up-regulates	R-1092	-0.976053	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
GABPA	up-regulates	R-1456	-1.00351	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
GABPA	up-regulates	R-1454	-1.00665	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
IRF9	up-regulates	R-1152	-1.01235	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
SRF	down-regulates	R-1790	-1.04379	Pr-27 Genes (8) AGMO, CALHM6, NHLRC2, DNM3, ITSN1, PLPP6 Regulons (8) R-2493, R-2777, R-1790, R-2323, R-2279, R-2558, R-2815, R-3194
IRF7	up-regulates	R-1090	-1.0469	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
IRF1	up-regulates	R-192	-1.06726	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
IRF9	up-regulates	R-1154	-1.10025	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
BRCA1	up-regulates	R-1032	1.10039	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
RREB1	down-regulates	R-2298	-1.11227	Pr-6 Genes (31) SART1, C11orf68, TALDO1, GPR150, ZNF543, COX14, ZNF571, KCTD2, PRKAG1, CSF1R, VMO1, SMDT1, SF3A3, TTC32, XPOT, KRBA2, MED12, APOBR, SDR42E1, FMNL1, ZBTB37, L3MBTL1, TRABD2A, CD55, ZNF34, DCHS2, CRIP1, NDUFA7 Regulons (31) R-46, R-2648, R-3177, R-869, R-2895, R-64, R-940, R-1917, R-3120, R-435, R-697, R-2958, R-886, R-1865, R-2783, R-1396, R-1420, R-1057, R-2768, R-2047, R-2528, R-2603, R-557, R-178, R-2874, R-70, R-2298, R-2329, R-2561, R-651, R-1845
RARA	down-regulates	R-157	1.1957	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
ATF1	up-regulates	R-571	-1.19606	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
RARA	down-regulates	R-164	1.24046	Pr-119 Genes (4) GPBAR1, RHD, GMFB, C5AR1 Regulons (4) R-832, R-1181, R-58, R-164
E2F2	up-regulates	R-2946	-1.27434	Pr-15 Genes (14) RBM33, RUFY4, SLC39A10, RPE, GLMP, MSRB1, BMPR2, SIPA1, VDAC1, EIF6, STON1, PRKDC Regulons (22) R-2088, R-2040, R-2207, R-282, R-2251, R-2946, R-1593, R-2737, R-1470, R-1848, R-1263, R-297, R-989, R-36, R-1782, R-1427, R-2049, R-2191, R-2288, R-1104, R-149, R-2959
IRF9	up-regulates	R-1158	1.2922	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
GABPA	up-regulates	R-1455	1.3231	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
POU2F2	down-regulates	R-2512	1.37817	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
ZBTB3	up-regulates	R-1268	1.42882	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
GABPA	up-regulates	R-1452	1.4809	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
JUN	down-regulates	R-1179	-1.50896	Pr-129 Genes (12) DALRD3, CTNNBIP1, FAHD1, ZBTB2, SLC2A4, UBA7, KLHDC8B, BCDIN3D, FAM111B, MAN1A2, HYLS1, INF2 Regulons (12) R-356, R-1920, R-2758, R-2274, R-507, R-1886, R-1777, R-1479, R-1180, R-2321, R-756, R-1179
SRF	down-regulates	R-1784	1.54282	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
KLF7	down-regulates	R-281	-1.54497	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
ZBTB3	up-regulates	R-1271	1.5513	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
SPDEF	down-regulates	R-1974	1.59808	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
RREB1	down-regulates	R-2291	-1.6207	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
SPDEF	down-regulates	R-1976	-1.62216	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
ZFX	down-regulates	R-1918	-1.62764	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
MYB	up-regulates	R-623	1.65419	Pr-96 Genes (6) SEMA4D, CTNND1, C4orf46, SAMD9, TNFRSF25, LILRA2 Regulons (7) R-171, R-8, R-1551, R-623, R-1590, R-649, R-793
VBP1	up-regulates	R-2102	1.67538	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
ELF3	down-regulates	R-2149	-1.67654	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
ZBTB4	down-regulates	R-2090	1.72041	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
ZBTB3	up-regulates	R-1263	-1.74288	Pr-15 Genes (14) RBM33, RUFY4, SLC39A10, RPE, GLMP, MSRB1, BMPR2, SIPA1, VDAC1, EIF6, STON1, PRKDC Regulons (22) R-2088, R-2040, R-2207, R-282, R-2251, R-2946, R-1593, R-2737, R-1470, R-1848, R-1263, R-297, R-989, R-36, R-1782, R-1427, R-2049, R-2191, R-2288, R-1104, R-149, R-2959
MAZ	up-regulates	R-511	-1.75904	Pr-0 Genes (84) GPX2, BNIP3, METRNL, PUS1, SAMD12, CD163, SLC25A20, EFCAB13, EXOSC4, SAMD4B, CATSPERE, C14orf119, ARHGAP45, BBS12, EHMT1, SETD2, ZBTB20, RFX7, TSKU, SRPRA, SLC25A10, ASB7, UPP1, LIN9, CCR10, ZFP1, USP18, TNFAIP2, CDNF, SOCS1, METTL7A, PDE6G, SP1, P4HB, DRG1, CXorf38, MORF4L1, AIDA, WWOX, SAPCD2, PPP1CC, SPIN4, CXCR3, ZNF397, TPCN1, CMC1, GCNT1, FNBP1, RSBN1L, LOC100288637, TMPPE, ZC3H6, ZNF669, NANOS1, ALKBH2, JPT1, LIN54, HLA-DRB1, ZNF493, EPHB4, TRAPPC2B, SIAH1, ESRRG, TCF4, SERTAD1, ZNF398, ZNF257, ATG7, MPEG1, RPS4X, PNP, HMGN2, HIST2H2BF, COLQ, RPS29 Regulons (86) R-180, R-2076, R-2157, R-3164, R-3147, R-338, R-2156, R-2409, R-885, R-941, R-1192, R-556, R-3197, R-1572, R-999, R-636, R-902, R-2541, R-440, R-890, R-3175, R-767, R-1542, R-1336, R-2472, R-1698, R-2326, R-1906, R-269, R-772, R-647, R-3033, R-2100, R-2711, R-1394, R-3068, R-508, R-63, R-1916, R-1188, R-532, R-2135, R-997, R-1687, R-2951, R-1853, R-2220, R-577, R-585, R-2597, R-1021, R-3119, R-301, R-559, R-1560, R-175, R-2870, R-3015, R-66, R-595, R-3185, R-2905, R-433, R-290, R-381, R-2509, R-562, R-2798, R-2206, R-1418, R-60, R-3050, R-2073, R-611, R-2488, R-881, R-1095, R-2153, R-2553, R-2305, R-2656, R-1697, R-511, R-2185, R-1492, R-2555
CEBPZ	up-regulates	R-758	1.76604	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
MAZ	up-regulates	R-495	1.8487	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
KLF7	down-regulates	R-289	-1.856	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ENSG00000176887	up-regulates	R-1900	1.8751	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
E2F2	up-regulates	R-2945	1.88745	Pr-133 Genes (6) UCP3, GJD4, ACOT4, HNRNPA0, ZCWPW2 Regulons (7) R-3071, R-1940, R-2231, R-372, R-2200, R-2945, R-2989
NRF1	down-regulates	R-2705	1.91369	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
NRF1	down-regulates	R-2704	1.94607	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
RREB1	down-regulates	R-2302	-1.95334	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
SPDEF	down-regulates	R-1964	1.96106	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
CREB1	down-regulates	R-274	-1.97415	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
PRDM4	down-regulates	R-3075	2.00508	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
E4F1	down-regulates	R-3148	-2.09252	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
KLF7	down-regulates	R-288	-2.09925	Pr-2 Genes (47) MSRA, PLEKHF2, NUPR1, IP6K1, TCP11L1, SPHK1, TYMS, FAM89B, WDR73, IRX3, ACAD9, CD151, KCNJ10, ARL6IP6, ODF3B, MPI, HYI, SPTY2D1, DAND5, ELMOD2, CDC42EP4, MAF1, SERTAD2, GLIPR1L2, LSMEM1, HIST3H2A, C5orf24, GINS3, RAD51B, MXRA7, BRICD5, RUVBL2, RBM12B, BRWD1, ANKRD37, TTC30B, SFI1, CTR9, CCDC167, PDXP Regulons (47) R-1855, R-2267, R-3037, R-486, R-2717, R-878, R-363, R-2104, R-631, R-3178, R-563, R-1911, R-436, R-183, R-2977, R-78, R-2479, R-2411, R-1825, R-49, R-272, R-390, R-1869, R-1831, R-2225, R-1586, R-775, R-535, R-1660, R-796, R-1574, R-1561, R-3126, R-2309, R-1717, R-2283, R-1341, R-2662, R-3007, R-2873, R-599, R-1189, R-2486, R-24, R-3064, R-570, R-288
RUNX2	up-regulates	R-1282	-2.24394	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
CREB1	down-regulates	R-278	-2.27835	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
TCF7L1	down-regulates	R-3170	-2.27892	Pr-14 Genes (17) TMEM70, TUBB6, PNMA1, CASKIN2, ANXA2R, MLF1, ARID3B, SLC17A8, FZD2, PLAG1, SLC8A1, SEMA4B, NOXA1, AKR1C3, MPV17L2 Regulons (18) R-1002, R-1429, R-1659, R-894, R-77, R-1832, R-1545, R-184, R-2284, R-2223, R-2075, R-2878, R-2606, R-1398, R-2952, R-1932, R-3170, R-2014
RREB1	down-regulates	R-2286	-2.31249	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
RUNX2	up-regulates	R-1283	2.3191	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
MAZ	up-regulates	R-499	-2.32628	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
GABPA	up-regulates	R-1458	-2.32781	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
NR4A2	down-regulates	R-1716	-2.35911	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
RARA	down-regulates	R-167	-2.36681	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
PATZ1	up-regulates	R-2196	2.39409	Pr-55 Genes (5) NR2C2AP, KCNK12, RACK1, KLHL23, AARSD1 Regulons (6) R-877, R-129, R-2602, R-478, R-2196, R-1944
RARA	down-regulates	R-169	2.42125	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
RREB1	down-regulates	R-2289	-2.4348	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
SRF	down-regulates	R-1786	2.43898	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
BRCA1	up-regulates	R-1033	-2.58375	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
RARA	down-regulates	R-151	-2.63142	Pr-61 Genes (2) HLA-DQA1, SCARF2 Regulons (13) R-1530, R-2176, R-151, R-637, R-153, R-2896, R-612, R-909, R-2375, R-1414, R-2980, R-653, R-1529
BRCA1	up-regulates	R-1031	2.71498	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
RUNX3	up-regulates	R-898	2.74094	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
TCF7L1	down-regulates	R-3173	-2.7488	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
IRF1	up-regulates	R-185	2.8096	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
NRF1	down-regulates	R-2703	2.85746	Pr-72 Genes (3) ZNF250, ZNF625 Regulons (13) R-1955, R-2746, R-714, R-693, R-705, R-2703, R-2530, R-1020, R-554, R-1391, R-2710, R-1743, R-831
ATF4	down-regulates	R-95	-2.89504	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
NFIA	up-regulates	R-354	-2.9087	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
JUN	down-regulates	R-1176	-2.91332	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
SPDEF	down-regulates	R-1966	-2.98845	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
STAT5B	up-regulates	R-2367	3.00488	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
IRF1	up-regulates	R-197	3.05156	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
POU2F2	down-regulates	R-2519	-3.13355	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-616	3.1672	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
ENSG00000138795	up-regulates	R-27	3.20229	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
MAZ	up-regulates	R-505	3.21974	Pr-70 Genes (1) SNURF Regulons (12) R-1694, R-505, R-1464, R-296, R-1781, R-2976, R-1469, R-73, R-942, R-1847, R-2281, R-2992
ENSG00000165066	up-regulates	R-3082	3.32738	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
IRF7	up-regulates	R-1087	3.35543	Pr-114 Genes (3) PCGF5, SAMD11, KCTD21 Regulons (7) R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107
ENSG00000176887	up-regulates	R-1892	3.42989	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
BRCA1	up-regulates	R-1030	-3.4552	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
RREB1	down-regulates	R-2292	-3.46394	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
MYB	up-regulates	R-625	3.48247	Pr-81 Genes (0) Regulons (4) R-1351, R-2993, R-6, R-625
MAZ	up-regulates	R-512	-3.50135	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
POU2F2	down-regulates	R-2511	-3.52119	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ZFX	down-regulates	R-1921	-3.52781	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
STAT5B	up-regulates	R-2370	3.57469	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
RARA	down-regulates	R-166	-3.60154	Pr-20 Genes (5) ZNF530, ERCC6L, NAP1L4, ZNF324B, RNASE4 Regulons (10) R-2300, R-2901, R-1936, R-2733, R-987, R-2297, R-3189, R-166, R-2726, R-2484
ENSG00000176887	up-regulates	R-1897	-3.60963	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
STAT3	down-regulates	R-307	-3.61941	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
ENSG00000165066	up-regulates	R-3081	3.73477	Pr-128 Genes (4) C10orf67, CLK3, PSTK Regulons (11) R-1200, R-1893, R-2641, R-1739, R-1183, R-1246, R-3081, R-225, R-1880, R-1475, R-90
KLF7	down-regulates	R-285	3.90122	Pr-74 Genes (1) MAP1LC3B2 Regulons (9) R-2514, R-2986, R-712, R-2759, R-285, R-343, R-995, R-2615, R-975
YY1	up-regulates	R-2525	3.91807	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
POU2F2	down-regulates	R-2520	-3.9229	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
SRF	down-regulates	R-1791	3.92786	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
MAZ	up-regulates	R-509	-4.01621	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
NFIA	up-regulates	R-355	4.10051	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
SRF	down-regulates	R-1781	4.13916	Pr-70 Genes (1) SNURF Regulons (12) R-1694, R-505, R-1464, R-296, R-1781, R-2976, R-1469, R-73, R-942, R-1847, R-2281, R-2992
E2F8	up-regulates	R-1629	4.14363	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
RREB1	down-regulates	R-2287	-4.14495	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
KLF7	down-regulates	R-280	-4.33884	Pr-44 Genes (0) Regulons (7) R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280
NRF1	down-regulates	R-2710	4.52843	Pr-72 Genes (3) ZNF250, ZNF625 Regulons (13) R-1955, R-2746, R-714, R-693, R-705, R-2703, R-2530, R-1020, R-554, R-1391, R-2710, R-1743, R-831
SRF	down-regulates	R-1785	4.55548	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
MAZ	up-regulates	R-506	-4.85353	Pr-4 Genes (37) B3GNT4, ZNF575, CRACR2B, ALS2CL, TCAIM, MED14, ADO, SFXN4, TM2D3, GAS2L1, EIF4EBP1, COL4A5, LRRK2, MXD3, ZBED8, CFAP97D1, WDR92, TMEM141, USP51, ZNF260, MTRNR2L8, CLLU1, CHURC1, CEP95, MRPL12, RPS10-NUDT3, YY1, BACH2, E2F2 Regulons (47) R-295, R-2879, R-2639, R-2318, R-3043, R-1908, R-1695, R-1554, R-2485, R-1767, R-777, R-443, R-1753, R-2114, R-1585, R-2824, R-1670, R-560, R-293, R-773, R-2432, R-270, R-2099, R-778, R-1778, R-1633, R-1277, R-1463, R-818, R-176, R-1573, R-1468, R-2599, R-2799, R-68, R-2950, R-2767, R-1174, R-990, R-2658, R-2221, R-2487, R-1684, R-3051, R-2813, R-1017, R-506
E2F1	up-regulates	R-2174	5.04725	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
IRF7	up-regulates	R-1088	5.08481	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
SRF	down-regulates	R-1787	-5.29074	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-621	-5.47246	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-618	5.69454	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
KLF7	down-regulates	R-283	7.07253	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
SRF	down-regulates	R-1780	7.20867	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
ARID5B	down-regulates	R-1096	7.71326	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
POU2F2	down-regulates	R-2518	8.01545	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
MYB	up-regulates	R-614	8.54513	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F2	up-regulates	R-2942	8.59906	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F8	up-regulates	R-1626	8.62493	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F8	up-regulates	R-1628	8.73321	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
E2F1	up-regulates	R-2173	8.76486	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F1	up-regulates	R-2172	8.82921	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F2	up-regulates	R-2944	8.90615	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
E2F8	up-regulates	R-1627	9.26408	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627

Causal Mechanistic Flows for Mutation TP53

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