Program

Causal Mechanistic Flows with regulons in program Pr-100

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_MAFB_Callup-regulatesENSG00000186564activatesR-4850.8833566Pr-100
t(14;16)up-regulatesENSG00000186564activatesR-4850.8833566Pr-100
DIS3down-regulatesGRHL1activatesR-3145-1.377247Pr-100
FAM46Cup-regulatesGRHL1activatesR-3145-1.377247Pr-100
FGFR3down-regulatesGRHL1activatesR-3145-1.377247Pr-100
IRF4down-regulatesGRHL1activatesR-3145-1.377247Pr-100
NRASup-regulatesGRHL1activatesR-3145-1.377247Pr-100
PRKD2down-regulatesGRHL1activatesR-3145-1.377247Pr-100
t(11;14)down-regulatesGRHL1activatesR-3145-1.377247Pr-100
RNASeq_FGFR3_Calldown-regulatesGRHL1activatesR-3145-1.377247Pr-100
MYCup-regulatesGRHL1activatesR-3145-1.377247Pr-100
t(4;14)down-regulatesGRHL1activatesR-3145-1.377247Pr-100
TRAF3down-regulatesGRHL1activatesR-3145-1.377247Pr-100
UNC80down-regulatesGRHL1activatesR-3145-1.377247Pr-100
t(4;14)_cytogeneticdown-regulatesGRHL1activatesR-3145-1.377247Pr-100
HUWE1down-regulatesARID5BactivatesR-1097-2.328056Pr-100
t(11;14)down-regulatesARID5BactivatesR-1097-2.328056Pr-100
RNASeq_MAFA_Calldown-regulatesHSF2activatesR-3161-2.8195112Pr-100
DIS3down-regulatesHMGA1activatesR-819-2.8756824Pr-100
FAM46Cup-regulatesHMGA1activatesR-819-2.8756824Pr-100
IRF4down-regulatesHMGA1activatesR-819-2.8756824Pr-100
NRASup-regulatesHMGA1activatesR-819-2.8756824Pr-100
PRKD2down-regulatesHMGA1activatesR-819-2.8756824Pr-100
t(11;14)down-regulatesHMGA1activatesR-819-2.8756824Pr-100
RNASeq_FGFR3_Calldown-regulatesHMGA1activatesR-819-2.8756824Pr-100
RNASeq_MAFA_Calldown-regulatesHMGA1activatesR-819-2.8756824Pr-100
t(4;14)down-regulatesHMGA1activatesR-819-2.8756824Pr-100
t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-819-2.8756824Pr-100
t(4;14)_cytogeneticdown-regulatesHMGA1activatesR-819-2.8756824Pr-100
ABCA13down-regulatesPOU2F1activatesR-74-2.9656436Pr-100
ABCA13down-regulatesFOXJ2activatesR-1423-3.1336434Pr-100
BAI3down-regulatesFOXO1activatesR-1397-3.2380332Pr-100
RNASeq_MAFA_Calldown-regulatesFOXO1activatesR-1397-3.2380332Pr-100
DIS3up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
FAM46Cdown-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
HUWE1up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
IRF4up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
NRASdown-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
PRKD2up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
t(11;14)up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
RNASeq_FGFR3_Callup-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
t(4;14)up-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
t(11;14)_cytogeneticup-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
t(4;14)_cytogeneticup-regulatesCEBPBrepressesR-1761-3.2982619Pr-100
ABCA13down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
DIS3down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
DNAH10down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
FAM46Cup-regulatesFOXO3activatesR-2771-3.3043328Pr-100
HUWE1down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
IRF4down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
NRASup-regulatesFOXO3activatesR-2771-3.3043328Pr-100
PCLOup-regulatesFOXO3activatesR-2771-3.3043328Pr-100
PKHD1L1down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
PRKD2down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
t(11;14)down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
RNASeq_MAFA_Calldown-regulatesFOXO3activatesR-2771-3.3043328Pr-100
SETD2down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
TRAF3down-regulatesFOXO3activatesR-2771-3.3043328Pr-100
t(11;14)_cytogeneticdown-regulatesFOXO3activatesR-2771-3.3043328Pr-100
t(4;14)_cytogeneticdown-regulatesFOXO3activatesR-2771-3.3043328Pr-100
DIS3down-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
FAM46Cup-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
NRASup-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
RNASeq_FGFR3_Calldown-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
RNASeq_MAFA_Calldown-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
t(4;14)down-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
SETD2down-regulatesMEF2AactivatesR-1868-3.3740133Pr-100
HUWE1down-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
IRF4down-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
t(11;14)down-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
RNASeq_MAFA_Calldown-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
TP53down-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
t(11;14)_cytogeneticdown-regulatesPOU2F2activatesR-2511-3.5211921Pr-100
NRASup-regulatesIRF1activatesR-187-3.6964127Pr-100
TRAF3down-regulatesIRF1activatesR-187-3.6964127Pr-100
AHNAK2down-regulatesRREB1activatesR-2287-4.1449519Pr-100
DNAH10down-regulatesRREB1activatesR-2287-4.1449519Pr-100
PRKD2down-regulatesRREB1activatesR-2287-4.1449519Pr-100
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2287-4.1449519Pr-100
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2287-4.1449519Pr-100
t(4;14)down-regulatesRREB1activatesR-2287-4.1449519Pr-100
SETD2down-regulatesRREB1activatesR-2287-4.1449519Pr-100
TP53down-regulatesRREB1activatesR-2287-4.1449519Pr-100
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2287-4.1449519Pr-100
DIS3down-regulatesKLF16activatesR-2692-4.1563615Pr-100
t(11;14)down-regulatesKLF16activatesR-2692-4.1563615Pr-100
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2692-4.1563615Pr-100
t(4;14)down-regulatesKLF16activatesR-2692-4.1563615Pr-100
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2692-4.1563615Pr-100
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2692-4.1563615Pr-100

Regulons in program Pr-100

Regulon Cox Hazard Ratio # genes # causal flows
R-4850.88335662
R-3145-1.37724713
R-1097-2.3280562
R-3161-2.81951121
R-819-2.875682411
R-74-2.96564361
R-1423-3.13364341
R-1397-3.23803322
R-1761-3.298261911
R-2771-3.304332816
R-1868-3.37401337
R-2511-3.52119216
R-187-3.69641272
R-2287-4.14495199
R-2692-4.15636156

Genes in program Pr-100

EnsEMBL IdEntrez IdPreferred
ENSG00000186566 23131GPATCH8
ENSG00000198382 7405UVRAG
ENSG00000257949 100134934TEN1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions