Program

Causal Mechanistic Flows with regulons in program Pr-58

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
COL12A1down-regulatesZNF740activatesR-3860.11148210Pr-58
FLGdown-regulatesZNF740activatesR-3860.11148210Pr-58
HUWE1up-regulatesZNF740activatesR-3860.11148210Pr-58
IRF4up-regulatesZNF740activatesR-3860.11148210Pr-58
KIAA1109down-regulatesZNF740activatesR-3860.11148210Pr-58
MAXdown-regulatesZNF740activatesR-3860.11148210Pr-58
PCLOdown-regulatesZNF740activatesR-3860.11148210Pr-58
t(11;14)up-regulatesZNF740activatesR-3860.11148210Pr-58
RNASeq_FGFR3_Calldown-regulatesZNF740activatesR-3860.11148210Pr-58
t(4;14)down-regulatesZNF740activatesR-3860.11148210Pr-58
amp1qdown-regulatesZNF740activatesR-3860.11148210Pr-58
del13down-regulatesZNF740activatesR-3860.11148210Pr-58
t(11;14)_cytogeneticup-regulatesZNF740activatesR-3860.11148210Pr-58
t(4;14)_cytogeneticdown-regulatesZNF740activatesR-3860.11148210Pr-58
FAM46Cdown-regulatesPEBP1activatesR-1756-0.298376Pr-58
IRF4up-regulatesPEBP1activatesR-1756-0.298376Pr-58
NRASdown-regulatesPEBP1activatesR-1756-0.298376Pr-58
t(11;14)up-regulatesPEBP1activatesR-1756-0.298376Pr-58
RNASeq_FGFR3_Callup-regulatesPEBP1activatesR-1756-0.298376Pr-58
t(4;14)up-regulatesPEBP1activatesR-1756-0.298376Pr-58
t(11;14)_cytogeneticup-regulatesPEBP1activatesR-1756-0.298376Pr-58
ATMup-regulatesMAFGactivatesR-1490-0.3001698Pr-58
BRAFup-regulatesMAFGactivatesR-1490-0.3001698Pr-58
t(11;14)up-regulatesMAFGactivatesR-1490-0.3001698Pr-58
t(14;16)up-regulatesMAFGactivatesR-1490-0.3001698Pr-58
t(4;14)up-regulatesMAFGactivatesR-1490-0.3001698Pr-58
t(11;14)_cytogeneticup-regulatesMAFGactivatesR-1490-0.3001698Pr-58
t(4;14)_cytogeneticup-regulatesMAFGactivatesR-1490-0.3001698Pr-58
CMYA5up-regulatesHMGA1repressesR-817-0.34299661Pr-58
DIS3down-regulatesHMGA1repressesR-817-0.34299661Pr-58
FAM46Cup-regulatesHMGA1repressesR-817-0.34299661Pr-58
IRF4down-regulatesHMGA1repressesR-817-0.34299661Pr-58
t(11;14)down-regulatesHMGA1repressesR-817-0.34299661Pr-58
RNASeq_CCND3_Calldown-regulatesHMGA1repressesR-817-0.34299661Pr-58
MYCup-regulatesHMGA1repressesR-817-0.34299661Pr-58
ROBO1up-regulatesHMGA1repressesR-817-0.34299661Pr-58
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-817-0.34299661Pr-58
DIS3down-regulatesPLAG1repressesR-1516-0.443931Pr-58
FAM46Cup-regulatesPLAG1repressesR-1516-0.443931Pr-58
IRF4down-regulatesPLAG1repressesR-1516-0.443931Pr-58
t(11;14)down-regulatesPLAG1repressesR-1516-0.443931Pr-58
t(11;14)_cytogeneticdown-regulatesPLAG1repressesR-1516-0.443931Pr-58
t(11;14)down-regulatesARID3ArepressesR-13420.51515116Pr-58
CMYA5up-regulatesE2F2repressesR-2943-0.53039814Pr-58
DNAH5up-regulatesE2F2repressesR-2943-0.53039814Pr-58
MACF1up-regulatesE2F2repressesR-2943-0.53039814Pr-58
MUC12up-regulatesE2F2repressesR-2943-0.53039814Pr-58
RELNup-regulatesE2F2repressesR-2943-0.53039814Pr-58
RNASeq_FGFR3_Callup-regulatesE2F2repressesR-2943-0.53039814Pr-58
t(14;16)up-regulatesE2F2repressesR-2943-0.53039814Pr-58
MYCup-regulatesE2F2repressesR-2943-0.53039814Pr-58
t(4;14)up-regulatesE2F2repressesR-2943-0.53039814Pr-58
TP53up-regulatesE2F2repressesR-2943-0.53039814Pr-58
amp1qup-regulatesE2F2repressesR-2943-0.53039814Pr-58
del17up-regulatesE2F2repressesR-2943-0.53039814Pr-58
del17pup-regulatesE2F2repressesR-2943-0.53039814Pr-58
amp1qup-regulatesETV3repressesR-2529-0.63143820Pr-58
del13up-regulatesETV3repressesR-2529-0.63143820Pr-58
DIS3up-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
DSCAML1down-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
FAM46Cdown-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
FRAS1up-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
HUWE1up-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
IRF4up-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
t(11;14)up-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
RNASeq_CCND2_Callup-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
RNASeq_CCND3_Callup-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
del17pdown-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
t(11;14)_cytogeneticup-regulatesBORCS8-MEF2BactivatesR-959-0.72145830Pr-58
COL12A1up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
HUWE1down-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
IRF4down-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
KLHL6up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
PCDH10up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
t(11;14)down-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
RNASeq_CCND3_Calldown-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
RNASeq_FGFR3_Callup-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
t(4;14)up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
ROBO1up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
del13up-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
t(11;14)_cytogeneticdown-regulatesPOU2F2repressesR-2510-0.78580853Pr-58
FGFR3up-regulatesTEAD1repressesR-1213-0.83181443Pr-58
t(11;14)down-regulatesTEAD1repressesR-1213-0.83181443Pr-58
RNASeq_FGFR3_Callup-regulatesTEAD1repressesR-1213-0.83181443Pr-58
t(4;14)up-regulatesTEAD1repressesR-1213-0.83181443Pr-58
amp1qup-regulatesTEAD1repressesR-1213-0.83181443Pr-58
del13up-regulatesTEAD1repressesR-1213-0.83181443Pr-58
t(11;14)_cytogeneticdown-regulatesTEAD1repressesR-1213-0.83181443Pr-58
t(4;14)_cytogeneticup-regulatesTEAD1repressesR-1213-0.83181443Pr-58
CMYA5down-regulatesZBTB16activatesR-578-0.87991743Pr-58
DIS3up-regulatesZBTB16activatesR-578-0.87991743Pr-58
DNAH5down-regulatesZBTB16activatesR-578-0.87991743Pr-58
DSTdown-regulatesZBTB16activatesR-578-0.87991743Pr-58
FAM46Cdown-regulatesZBTB16activatesR-578-0.87991743Pr-58
IRF4up-regulatesZBTB16activatesR-578-0.87991743Pr-58
LRP2down-regulatesZBTB16activatesR-578-0.87991743Pr-58
MUC12down-regulatesZBTB16activatesR-578-0.87991743Pr-58
t(11;14)up-regulatesZBTB16activatesR-578-0.87991743Pr-58
t(11;14)_cytogeneticup-regulatesZBTB16activatesR-578-0.87991743Pr-58
t(14;16)_cytogeneticdown-regulatesZBTB16activatesR-578-0.87991743Pr-58
RNASeq_MAFA_Callup-regulatesELK1repressesR-6410.88472214Pr-58
t(14;16)up-regulatesELK1repressesR-6410.88472214Pr-58
amp1qup-regulatesELK1repressesR-6410.88472214Pr-58
del13up-regulatesELK1repressesR-6410.88472214Pr-58
CMYA5down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
COL12A1down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
DNAH5down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
DSTdown-regulatesSMAD4activatesR-2353-0.94676922Pr-58
KIAA1109down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
LRP2down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
PCDH10down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
PKHD1L1down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
t(11;14)up-regulatesSMAD4activatesR-2353-0.94676922Pr-58
ROBO1down-regulatesSMAD4activatesR-2353-0.94676922Pr-58
t(11;14)_cytogeneticup-regulatesSMAD4activatesR-2353-0.94676922Pr-58
DSTdown-regulatesELF1activatesR-2974-0.97714748Pr-58
PCDH10down-regulatesELF1activatesR-2974-0.97714748Pr-58
t(11;14)up-regulatesELF1activatesR-2974-0.97714748Pr-58
t(11;14)_cytogeneticup-regulatesELF1activatesR-2974-0.97714748Pr-58
DSTdown-regulatesELF1activatesR-29821.0065317Pr-58
KRASup-regulatesELF1activatesR-29821.0065317Pr-58
t(11;14)up-regulatesELF1activatesR-29821.0065317Pr-58
t(11;14)_cytogeneticup-regulatesELF1activatesR-29821.0065317Pr-58
t(14;16)down-regulatesTCF3activatesR-20541.0807432Pr-58
ATMdown-regulatesHMGA1repressesR-8331.08186Pr-58
DIS3down-regulatesHMGA1repressesR-8331.08186Pr-58
IRF4down-regulatesHMGA1repressesR-8331.08186Pr-58
NRASup-regulatesHMGA1repressesR-8331.08186Pr-58
t(11;14)down-regulatesHMGA1repressesR-8331.08186Pr-58
RNASeq_MAFA_Calldown-regulatesHMGA1repressesR-8331.08186Pr-58
RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-8331.08186Pr-58
t(14;16)down-regulatesHMGA1repressesR-8331.08186Pr-58
ROBO1up-regulatesHMGA1repressesR-8331.08186Pr-58
t(11;14)_cytogeneticdown-regulatesHMGA1repressesR-8331.08186Pr-58
FAM46Cdown-regulatesFOSactivatesR-2190-1.0879920Pr-58
KIAA1109down-regulatesFOSactivatesR-2190-1.0879920Pr-58
t(11;14)up-regulatesFOSactivatesR-2190-1.0879920Pr-58
RNASeq_CCND3_Callup-regulatesFOSactivatesR-2190-1.0879920Pr-58
t(14;16)down-regulatesFOSactivatesR-2190-1.0879920Pr-58
MYCdown-regulatesFOSactivatesR-2190-1.0879920Pr-58
ROBO1down-regulatesFOSactivatesR-2190-1.0879920Pr-58
amp1qdown-regulatesFOSactivatesR-2190-1.0879920Pr-58
del13down-regulatesFOSactivatesR-2190-1.0879920Pr-58
t(11;14)_cytogeneticup-regulatesFOSactivatesR-2190-1.0879920Pr-58
DIS3down-regulatesPITX1repressesR-657-1.0987434Pr-58
FAM46Cup-regulatesPITX1repressesR-657-1.0987434Pr-58
t(11;14)down-regulatesPITX1repressesR-657-1.0987434Pr-58
MYCup-regulatesPITX1repressesR-657-1.0987434Pr-58
t(11;14)_cytogeneticdown-regulatesPITX1repressesR-657-1.0987434Pr-58
AHNAK2down-regulatesELF2activatesR-964-1.1185742Pr-58
MACF1down-regulatesELF2activatesR-964-1.1185742Pr-58
NEBdown-regulatesELF2activatesR-964-1.1185742Pr-58
PCDH10down-regulatesELF2activatesR-964-1.1185742Pr-58
RNASeq_MAFA_Calldown-regulatesELF2activatesR-964-1.1185742Pr-58
CMYA5down-regulatesPOU2F1activatesR-67-1.13734103Pr-58
DNAH5down-regulatesPOU2F1activatesR-67-1.13734103Pr-58
MACF1down-regulatesPOU2F1activatesR-67-1.13734103Pr-58
t(11;14)up-regulatesPOU2F1activatesR-67-1.13734103Pr-58
MYCdown-regulatesPOU2F1activatesR-67-1.13734103Pr-58
del17down-regulatesPOU2F1activatesR-67-1.13734103Pr-58
del17pdown-regulatesPOU2F1activatesR-67-1.13734103Pr-58
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-67-1.13734103Pr-58
ANK2down-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
CMYA5down-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
DNAH5down-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
KRASup-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
MYO10down-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
NEBdown-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
t(11;14)up-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
RNASeq_MAFA_Calldown-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
del17down-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
del17pdown-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-2871-1.1455189Pr-58
COL12A1down-regulatesPATZ1activatesR-2195-1.1532812Pr-58
DIS3up-regulatesPATZ1activatesR-2195-1.1532812Pr-58
DSTdown-regulatesPATZ1activatesR-2195-1.1532812Pr-58
IRF4up-regulatesPATZ1activatesR-2195-1.1532812Pr-58
KIAA1244down-regulatesPATZ1activatesR-2195-1.1532812Pr-58
KRASup-regulatesPATZ1activatesR-2195-1.1532812Pr-58
PRKD2up-regulatesPATZ1activatesR-2195-1.1532812Pr-58
t(11;14)up-regulatesPATZ1activatesR-2195-1.1532812Pr-58
amp1qdown-regulatesPATZ1activatesR-2195-1.1532812Pr-58
t(11;14)_cytogeneticup-regulatesPATZ1activatesR-2195-1.1532812Pr-58
COL12A1down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
DIS3up-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
FAT1down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
IRF4up-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
KLHL6down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
RELNdown-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
t(11;14)up-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
RNASeq_FGFR3_Calldown-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
t(14;16)down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
t(4;14)down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
ROBO1down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
amp1qdown-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
del13down-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
t(11;14)_cytogeneticup-regulatesENSG00000165066activatesR-3076-1.2154925Pr-58
DIS3up-regulatesYY1activatesR-25211.3742320Pr-58
PRKD2up-regulatesYY1activatesR-25211.3742320Pr-58
TRAF3down-regulatesYY1activatesR-25211.3742320Pr-58
DIS3up-regulatesENSG00000176887activatesR-18941.463429Pr-58
FGFR3up-regulatesENSG00000176887activatesR-18941.463429Pr-58
t(11;14)up-regulatesENSG00000176887activatesR-18941.463429Pr-58
RNASeq_FGFR3_Callup-regulatesENSG00000176887activatesR-18941.463429Pr-58
t(4;14)up-regulatesENSG00000176887activatesR-18941.463429Pr-58
t(11;14)_cytogeneticup-regulatesENSG00000176887activatesR-18941.463429Pr-58
t(4;14)_cytogeneticup-regulatesENSG00000176887activatesR-18941.463429Pr-58
ANK2down-regulatesE4F1activatesR-3148-2.092526Pr-58
CMYA5down-regulatesE4F1activatesR-3148-2.092526Pr-58
IRF4up-regulatesE4F1activatesR-3148-2.092526Pr-58
KRASup-regulatesE4F1activatesR-3148-2.092526Pr-58
t(11;14)up-regulatesE4F1activatesR-3148-2.092526Pr-58
MYCdown-regulatesE4F1activatesR-3148-2.092526Pr-58
TP53down-regulatesE4F1activatesR-3148-2.092526Pr-58
amp1qdown-regulatesE4F1activatesR-3148-2.092526Pr-58
del17pdown-regulatesE4F1activatesR-3148-2.092526Pr-58
t(11;14)_cytogeneticup-regulatesE4F1activatesR-3148-2.092526Pr-58

Regulons in program Pr-58

Regulon Cox Hazard Ratio # genes # causal flows
R-3860.1114821014
R-1756-0.2983767
R-1490-0.30016987
R-817-0.342996619
R-1516-0.4439315
R-13420.515151161
R-2943-0.5303981413
R-2529-0.631438202
R-959-0.7214583011
R-2510-0.7858085312
R-1213-0.831814438
R-578-0.8799174311
R-6410.884722144
R-2353-0.9467692211
R-2974-0.977147484
R-29821.00653174
R-20541.08074321
R-8331.0818610
R-2190-1.087992010
R-657-1.09874345
R-964-1.11857425
R-67-1.137341038
R-2871-1.145518911
R-2195-1.153281210
R-3076-1.215492514
R-25211.37423203
R-18941.4634297
R-3148-2.09252610

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions