Program

Causal Mechanistic Flows with regulons in program Pr-72

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesGABPB1repressesR-19551.091016Pr-72
PTPRDdown-regulatesGABPB1repressesR-19551.091016Pr-72
t(11;14)up-regulatesGABPB1repressesR-19551.091016Pr-72
RNASeq_CCND2_Calldown-regulatesGABPB1repressesR-19551.091016Pr-72
DIS3down-regulatesESRRAactivatesR-27461.177357Pr-72
FAM46Cup-regulatesESRRAactivatesR-27461.177357Pr-72
IRF4down-regulatesESRRAactivatesR-27461.177357Pr-72
KIAA1244up-regulatesESRRAactivatesR-27461.177357Pr-72
t(11;14)down-regulatesESRRAactivatesR-27461.177357Pr-72
RNASeq_FGFR3_Calldown-regulatesESRRAactivatesR-27461.177357Pr-72
MYCup-regulatesESRRAactivatesR-27461.177357Pr-72
t(4;14)down-regulatesESRRAactivatesR-27461.177357Pr-72
t(11;14)_cytogeneticdown-regulatesESRRAactivatesR-27461.177357Pr-72
AHNAK2down-regulatesETV6repressesR-7142.324559Pr-72
ASXL3down-regulatesETV6repressesR-7142.324559Pr-72
MAGEC1down-regulatesETV6repressesR-7142.324559Pr-72
RNASeq_FGFR3_Callup-regulatesETV6repressesR-7142.324559Pr-72
t(4;14)up-regulatesETV6repressesR-7142.324559Pr-72
amp1qup-regulatesETV6repressesR-7142.324559Pr-72
del13up-regulatesETV6repressesR-7142.324559Pr-72
t(4;14)_cytogeneticup-regulatesETV6repressesR-7142.324559Pr-72
AHNAK2down-regulatesETV6repressesR-6932.5296938Pr-72
PCDH10down-regulatesETV6repressesR-6932.5296938Pr-72
RNASeq_FGFR3_Callup-regulatesETV6repressesR-6932.5296938Pr-72
t(4;14)up-regulatesETV6repressesR-6932.5296938Pr-72
del13up-regulatesETV6repressesR-6932.5296938Pr-72
t(4;14)_cytogeneticup-regulatesETV6repressesR-6932.5296938Pr-72
RNASeq_FGFR3_Callup-regulatesETV6repressesR-7052.5870413Pr-72
t(4;14)up-regulatesETV6repressesR-7052.5870413Pr-72
del13up-regulatesETV6repressesR-7052.5870413Pr-72
t(4;14)_cytogeneticup-regulatesETV6repressesR-7052.5870413Pr-72
AHNAK2down-regulatesNRF1repressesR-27032.8574631Pr-72
DNAH5down-regulatesNRF1repressesR-27032.8574631Pr-72
NEBdown-regulatesNRF1repressesR-27032.8574631Pr-72
PTPRDdown-regulatesNRF1repressesR-27032.8574631Pr-72
t(11;14)up-regulatesNRF1repressesR-27032.8574631Pr-72
MYCdown-regulatesNRF1repressesR-27032.8574631Pr-72
SDK1down-regulatesNRF1repressesR-27032.8574631Pr-72
SYNE1down-regulatesNRF1repressesR-27032.8574631Pr-72
TP53down-regulatesNRF1repressesR-27032.8574631Pr-72
del13up-regulatesNRF1repressesR-27032.8574631Pr-72
del17down-regulatesNRF1repressesR-27032.8574631Pr-72
del17pdown-regulatesNRF1repressesR-27032.8574631Pr-72
t(11;14)_cytogeneticup-regulatesNRF1repressesR-27032.8574631Pr-72
AHNAK2down-regulatesETV3repressesR-25302.9377216Pr-72
FAT3down-regulatesETV3repressesR-25302.9377216Pr-72
SYNE1down-regulatesETV3repressesR-25302.9377216Pr-72
TACC2down-regulatesETV3repressesR-25302.9377216Pr-72
del13up-regulatesETV3repressesR-25302.9377216Pr-72
MAGI1down-regulatesENSG00000054598repressesR-10203.392077Pr-72
NEBdown-regulatesENSG00000054598repressesR-10203.392077Pr-72
PTPRDdown-regulatesENSG00000054598repressesR-10203.392077Pr-72
t(11;14)up-regulatesENSG00000054598repressesR-10203.392077Pr-72
MYCdown-regulatesENSG00000054598repressesR-10203.392077Pr-72
del17down-regulatesENSG00000054598repressesR-10203.392077Pr-72
t(14;16)_cytogeneticdown-regulatesENSG00000054598repressesR-10203.392077Pr-72
MAGI1down-regulatesBCL6repressesR-5543.392077Pr-72
NEBdown-regulatesBCL6repressesR-5543.392077Pr-72
t(11;14)up-regulatesBCL6repressesR-5543.392077Pr-72
MYCdown-regulatesBCL6repressesR-5543.392077Pr-72
SYNE1down-regulatesBCL6repressesR-5543.392077Pr-72
del17down-regulatesBCL6repressesR-5543.392077Pr-72
t(14;16)_cytogeneticdown-regulatesBCL6repressesR-5543.392077Pr-72
PKHD1L1down-regulatesNR2C2repressesR-13913.418446Pr-72
RNASeq_MAFA_Calldown-regulatesNR2C2repressesR-13913.418446Pr-72
AHNAK2down-regulatesNRF1repressesR-27104.528436Pr-72
DNAH5down-regulatesNRF1repressesR-27104.528436Pr-72
NEBdown-regulatesNRF1repressesR-27104.528436Pr-72
PTPRDdown-regulatesNRF1repressesR-27104.528436Pr-72
t(11;14)up-regulatesNRF1repressesR-27104.528436Pr-72
MYCdown-regulatesNRF1repressesR-27104.528436Pr-72
SDK1down-regulatesNRF1repressesR-27104.528436Pr-72
SYNE1down-regulatesNRF1repressesR-27104.528436Pr-72
TP53down-regulatesNRF1repressesR-27104.528436Pr-72
del17down-regulatesNRF1repressesR-27104.528436Pr-72
del17pdown-regulatesNRF1repressesR-27104.528436Pr-72
t(11;14)_cytogeneticup-regulatesNRF1repressesR-27104.528436Pr-72
LRP1Bdown-regulatesMAFBrepressesR-17435.343719Pr-72
MUC12down-regulatesMAFBrepressesR-17435.343719Pr-72
PKHD1L1down-regulatesMAFBrepressesR-17435.343719Pr-72
RELNdown-regulatesMAFBrepressesR-17435.343719Pr-72
t(11;14)up-regulatesMAFBrepressesR-17435.343719Pr-72
t(14;16)down-regulatesMAFBrepressesR-17435.343719Pr-72
MYCdown-regulatesMAFBrepressesR-17435.343719Pr-72
t(14;16)_cytogeneticdown-regulatesMAFBrepressesR-17435.343719Pr-72
CMYA5up-regulatesHMGA1activatesR-8316.733316Pr-72
FGFR3down-regulatesHMGA1activatesR-8316.733316Pr-72
NRASup-regulatesHMGA1activatesR-8316.733316Pr-72
RNASeq_FGFR3_Calldown-regulatesHMGA1activatesR-8316.733316Pr-72
MYCup-regulatesHMGA1activatesR-8316.733316Pr-72
t(4;14)down-regulatesHMGA1activatesR-8316.733316Pr-72
del13down-regulatesHMGA1activatesR-8316.733316Pr-72
t(4;14)_cytogeneticdown-regulatesHMGA1activatesR-8316.733316Pr-72

Regulons in program Pr-72

Regulon Cox Hazard Ratio # genes # causal flows
R-19551.0910164
R-27461.1773579
R-7142.3245598
R-6932.52969386
R-7052.58704134
R-27032.857463113
R-25302.93772165
R-10203.3920777
R-5543.3920777
R-13913.4184462
R-27104.52843612
R-17435.3437198
R-8316.7333168

Genes in program Pr-72

EnsEMBL IdEntrez IdPreferred
ENSG00000196150 58500ZNF250
ENSG00000196935
ENSG00000257591 90589ZNF625

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions