Program

Causal Mechanistic Flows with regulons in program Pr-107

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
BAI3down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

KDM3Bdown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

RNASeq_FGFR3_Callup-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

RNASeq_MAFA_Calldown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

RNASeq_MAFB_Calldown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(14;16)down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

MYCdown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(4;14)up-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

ROBO2down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

SYNE1down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

ZNF462down-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)_cytogeneticdown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(14;16)_cytogeneticdown-regulatesCREB3L2activatesR-521-1.291286Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

DIS3up-regulatesYY1repressesR-2523-2.2820318Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

DNAH10up-regulatesYY1repressesR-2523-2.2820318Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

PRKD2up-regulatesYY1repressesR-2523-2.2820318Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

RNASeq_MAFA_Callup-regulatesYY1repressesR-2523-2.2820318Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

IRF4down-regulatesXBP1activatesR-3056-2.384999Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)down-regulatesXBP1activatesR-3056-2.384999Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

RNASeq_MAFA_Calldown-regulatesXBP1activatesR-3056-2.384999Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)_cytogeneticdown-regulatesXBP1activatesR-3056-2.384999Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

IRF4up-regulatesRARArepressesR-154-2.9074817Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)up-regulatesRARArepressesR-154-2.9074817Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

del13up-regulatesRARArepressesR-154-2.9074817Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

t(11;14)_cytogeneticup-regulatesRARArepressesR-154-2.9074817Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

Regulons in program Pr-107

Regulon Cox Hazard Ratio # genes # causal flows
R-521-1.29128614
R-2523-2.28203184
R-3056-2.3849994
R-154-2.90748174

Genes in program Pr-107

EnsEMBL IdEntrez IdPreferred
ENSG00000197837 121504HIST4H4
ENSG00000254999 55845BRK1
ENSG00000262180 10896OCLM

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions