Program

Causal Mechanistic Flows with regulons in program Pr-38

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3down-regulatesTP53activatesR-3760.1271148Pr-38
FAM46Cup-regulatesTP53activatesR-3760.1271148Pr-38
MAXdown-regulatesTP53activatesR-3760.1271148Pr-38
NRASup-regulatesTP53activatesR-3760.1271148Pr-38
PTPRDup-regulatesTP53activatesR-3760.1271148Pr-38
RNASeq_FGFR3_Calldown-regulatesTP53activatesR-3760.1271148Pr-38
t(14;16)down-regulatesTP53activatesR-3760.1271148Pr-38
MYCup-regulatesTP53activatesR-3760.1271148Pr-38
t(4;14)down-regulatesTP53activatesR-3760.1271148Pr-38
UBR4up-regulatesTP53activatesR-3760.1271148Pr-38
amp1qdown-regulatesTP53activatesR-3760.1271148Pr-38
del13down-regulatesTP53activatesR-3760.1271148Pr-38
t(4;14)_cytogeneticdown-regulatesTP53activatesR-3760.1271148Pr-38
DIS3down-regulatesHOXA3activatesR-2271.498536Pr-38
FAM46Cup-regulatesHOXA3activatesR-2271.498536Pr-38
IRF4down-regulatesHOXA3activatesR-2271.498536Pr-38
KLHL6up-regulatesHOXA3activatesR-2271.498536Pr-38
t(11;14)down-regulatesHOXA3activatesR-2271.498536Pr-38
RNASeq_MAFB_Calldown-regulatesHOXA3activatesR-2271.498536Pr-38
t(14;16)down-regulatesHOXA3activatesR-2271.498536Pr-38
t(11;14)_cytogeneticdown-regulatesHOXA3activatesR-2271.498536Pr-38
t(11;14)up-regulatesELK1repressesR-655-2.042596Pr-38
t(14;16)up-regulatesELK1repressesR-655-2.042596Pr-38
amp1qup-regulatesELK1repressesR-655-2.042596Pr-38
del13up-regulatesELK1repressesR-655-2.042596Pr-38
IRF4up-regulatesRARArepressesR-158-2.6925513Pr-38
t(11;14)up-regulatesRARArepressesR-158-2.6925513Pr-38
del13up-regulatesRARArepressesR-158-2.6925513Pr-38
t(11;14)_cytogeneticup-regulatesRARArepressesR-158-2.6925513Pr-38
DIS3up-regulatesZBTB16repressesR-584-2.8377313Pr-38
FAM46Cdown-regulatesZBTB16repressesR-584-2.8377313Pr-38
IRF4up-regulatesZBTB16repressesR-584-2.8377313Pr-38
PRKD2up-regulatesZBTB16repressesR-584-2.8377313Pr-38
t(11;14)up-regulatesZBTB16repressesR-584-2.8377313Pr-38
RNASeq_FGFR3_Callup-regulatesZBTB16repressesR-584-2.8377313Pr-38
t(4;14)up-regulatesZBTB16repressesR-584-2.8377313Pr-38
t(11;14)_cytogeneticup-regulatesZBTB16repressesR-584-2.8377313Pr-38
t(4;14)_cytogeneticup-regulatesZBTB16repressesR-584-2.8377313Pr-38
DIS3down-regulatesPITX1activatesR-659-3.051428Pr-38
FAM46Cup-regulatesPITX1activatesR-659-3.051428Pr-38
NRASup-regulatesPITX1activatesR-659-3.051428Pr-38
t(11;14)down-regulatesPITX1activatesR-659-3.051428Pr-38
RNASeq_FGFR3_Calldown-regulatesPITX1activatesR-659-3.051428Pr-38
RNASeq_MAFA_Calldown-regulatesPITX1activatesR-659-3.051428Pr-38
t(4;14)down-regulatesPITX1activatesR-659-3.051428Pr-38
TRAF3down-regulatesPITX1activatesR-659-3.051428Pr-38
del13down-regulatesPITX1activatesR-659-3.051428Pr-38
t(11;14)_cytogeneticdown-regulatesPITX1activatesR-659-3.051428Pr-38
AHNAK2down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
DIS3down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
FAM46Cup-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
FAT3down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
MACF1down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
MAXdown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
NRASup-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
PTPRDdown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
RNASeq_FGFR3_Calldown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
RNASeq_MAFA_Calldown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
RNASeq_MAFB_Calldown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
t(4;14)down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
SETD2down-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
t(14;16)_cytogeneticdown-regulatesMEF2AactivatesR-1877-3.2002220Pr-38
ATMup-regulatesETV6repressesR-710-3.2878410Pr-38
RNASeq_FGFR3_Callup-regulatesETV6repressesR-710-3.2878410Pr-38
RNASeq_MAFB_Callup-regulatesETV6repressesR-710-3.2878410Pr-38
t(14;16)up-regulatesETV6repressesR-710-3.2878410Pr-38
t(4;14)up-regulatesETV6repressesR-710-3.2878410Pr-38
amp1qup-regulatesETV6repressesR-710-3.2878410Pr-38
del13up-regulatesETV6repressesR-710-3.2878410Pr-38
t(4;14)_cytogeneticup-regulatesETV6repressesR-710-3.2878410Pr-38
AHNAK2up-regulatesMYBrepressesR-620-3.3754110Pr-38
ATMup-regulatesMYBrepressesR-620-3.3754110Pr-38
DIS3up-regulatesMYBrepressesR-620-3.3754110Pr-38
FAM46Cdown-regulatesMYBrepressesR-620-3.3754110Pr-38
FLGup-regulatesMYBrepressesR-620-3.3754110Pr-38
IRF4up-regulatesMYBrepressesR-620-3.3754110Pr-38
MACF1up-regulatesMYBrepressesR-620-3.3754110Pr-38
NRASdown-regulatesMYBrepressesR-620-3.3754110Pr-38
PTPRDup-regulatesMYBrepressesR-620-3.3754110Pr-38
t(11;14)up-regulatesMYBrepressesR-620-3.3754110Pr-38
RNASeq_FGFR3_Callup-regulatesMYBrepressesR-620-3.3754110Pr-38
RNASeq_MAFA_Callup-regulatesMYBrepressesR-620-3.3754110Pr-38
RNASeq_MAFB_Callup-regulatesMYBrepressesR-620-3.3754110Pr-38
t(14;16)up-regulatesMYBrepressesR-620-3.3754110Pr-38
t(4;14)up-regulatesMYBrepressesR-620-3.3754110Pr-38
ROBO2up-regulatesMYBrepressesR-620-3.3754110Pr-38
TRIOup-regulatesMYBrepressesR-620-3.3754110Pr-38
amp1qup-regulatesMYBrepressesR-620-3.3754110Pr-38
del13up-regulatesMYBrepressesR-620-3.3754110Pr-38
t(14;16)_cytogeneticup-regulatesMYBrepressesR-620-3.3754110Pr-38
t(4;14)_cytogeneticup-regulatesMYBrepressesR-620-3.3754110Pr-38
DIS3up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
FAM46Cdown-regulatesCEBPBrepressesR-1774-3.924868Pr-38
HUWE1up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
IRF4up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
MAXup-regulatesCEBPBrepressesR-1774-3.924868Pr-38
NRASdown-regulatesCEBPBrepressesR-1774-3.924868Pr-38
PRKD2up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
t(11;14)up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
RNASeq_FGFR3_Callup-regulatesCEBPBrepressesR-1774-3.924868Pr-38
t(4;14)up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
SETD2up-regulatesCEBPBrepressesR-1774-3.924868Pr-38
TRIOup-regulatesCEBPBrepressesR-1774-3.924868Pr-38
t(11;14)_cytogeneticup-regulatesCEBPBrepressesR-1774-3.924868Pr-38
t(4;14)_cytogeneticup-regulatesCEBPBrepressesR-1774-3.924868Pr-38
AHNAK2up-regulatesSP1repressesR-2734-3.9868213Pr-38
DIS3up-regulatesSP1repressesR-2734-3.9868213Pr-38
DNAH9up-regulatesSP1repressesR-2734-3.9868213Pr-38
FAM46Cdown-regulatesSP1repressesR-2734-3.9868213Pr-38
FAT3up-regulatesSP1repressesR-2734-3.9868213Pr-38
IRF4up-regulatesSP1repressesR-2734-3.9868213Pr-38
RNASeq_FGFR3_Callup-regulatesSP1repressesR-2734-3.9868213Pr-38
RNASeq_MAFA_Callup-regulatesSP1repressesR-2734-3.9868213Pr-38
RNASeq_MAFB_Callup-regulatesSP1repressesR-2734-3.9868213Pr-38
t(14;16)up-regulatesSP1repressesR-2734-3.9868213Pr-38
t(4;14)up-regulatesSP1repressesR-2734-3.9868213Pr-38
ROBO2up-regulatesSP1repressesR-2734-3.9868213Pr-38
TRAF3up-regulatesSP1repressesR-2734-3.9868213Pr-38
TRIOup-regulatesSP1repressesR-2734-3.9868213Pr-38
t(14;16)_cytogeneticup-regulatesSP1repressesR-2734-3.9868213Pr-38
t(4;14)_cytogeneticup-regulatesSP1repressesR-2734-3.9868213Pr-38
FGFR3up-regulatesPOU2F2activatesR-2516-5.216067Pr-38
HUWE1down-regulatesPOU2F2activatesR-2516-5.216067Pr-38
IRF4down-regulatesPOU2F2activatesR-2516-5.216067Pr-38
KDM3Bdown-regulatesPOU2F2activatesR-2516-5.216067Pr-38
KLHL6up-regulatesPOU2F2activatesR-2516-5.216067Pr-38
t(11;14)down-regulatesPOU2F2activatesR-2516-5.216067Pr-38
RNASeq_FGFR3_Callup-regulatesPOU2F2activatesR-2516-5.216067Pr-38
RNASeq_MAFA_Calldown-regulatesPOU2F2activatesR-2516-5.216067Pr-38
RNASeq_MAFB_Calldown-regulatesPOU2F2activatesR-2516-5.216067Pr-38
t(14;16)down-regulatesPOU2F2activatesR-2516-5.216067Pr-38
t(4;14)up-regulatesPOU2F2activatesR-2516-5.216067Pr-38
t(11;14)_cytogeneticdown-regulatesPOU2F2activatesR-2516-5.216067Pr-38

Regulons in program Pr-38

Regulon Cox Hazard Ratio # genes # causal flows
R-3760.127114813
R-2271.4985368
R-655-2.0425964
R-158-2.69255134
R-584-2.83773139
R-659-3.05142810
R-1877-3.200222014
R-710-3.28784108
R-620-3.375411021
R-1774-3.92486814
R-2734-3.986821316
R-2516-5.21606712

Genes in program Pr-38

EnsEMBL IdEntrez IdPreferred
ENSG00000176407 56888KCMF1
ENSG00000198959 7052TGM2
ENSG00000237172 84752B3GNT9

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions