Program

Causal Mechanistic Flows with regulons in program Pr-30

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
RNASeq_FGFR3_Callup-regulatesTHRAactivatesR-59-0.6445386Pr-30
t(4;14)up-regulatesTHRAactivatesR-59-0.6445386Pr-30
TP53down-regulatesTHRAactivatesR-59-0.6445386Pr-30
amp1qup-regulatesTHRAactivatesR-59-0.6445386Pr-30
del13up-regulatesTHRAactivatesR-59-0.6445386Pr-30
PRKD2down-regulatesTEFrepressesR-2407-1.3262510Pr-30
RNASeq_FGFR3_Calldown-regulatesTEFrepressesR-2407-1.3262510Pr-30
t(4;14)down-regulatesTEFrepressesR-2407-1.3262510Pr-30
amp1qdown-regulatesTEFrepressesR-2407-1.3262510Pr-30
del13down-regulatesTEFrepressesR-2407-1.3262510Pr-30
EGR1down-regulatesZNF143repressesR-2315-1.774929Pr-30
FAT3up-regulatesZNF143repressesR-2315-1.774929Pr-30
FAT3down-regulatesZNF281activatesR-2482-2.3457915Pr-30
t(11;14)up-regulatesZNF281activatesR-2482-2.3457915Pr-30
del13up-regulatesZNF281activatesR-2482-2.3457915Pr-30
t(11;14)_cytogeneticup-regulatesZNF281activatesR-2482-2.3457915Pr-30
DIS3up-regulatesSP1repressesR-2723-2.3886322Pr-30
FAT3up-regulatesSP1repressesR-2723-2.3886322Pr-30
RNASeq_MAFA_Callup-regulatesSP1repressesR-2723-2.3886322Pr-30
t(14;16)up-regulatesSP1repressesR-2723-2.3886322Pr-30
SVILup-regulatesSP1repressesR-2723-2.3886322Pr-30
MYCdown-regulatesDBPrepressesR-2957-2.398816Pr-30
ROBO1down-regulatesDBPrepressesR-2957-2.398816Pr-30

Regulons in program Pr-30

Regulon Cox Hazard Ratio # genes # causal flows
R-59-0.64453865
R-2407-1.32625105
R-2315-1.7749292
R-2482-2.34579154
R-2723-2.38863225
R-2957-2.3988162

Genes in program Pr-30

EnsEMBL IdEntrez IdPreferred
ENSG00000183624 56941HMCES
ENSG00000198108 337876CHSY3
ENSG00000213918 1773DNASE1
ENSG00000258839 4157MC1R
ENSG00000262576 56111PCDHGA4
ENSG00000267697 767558LUZP6

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions