Program

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

Causal Mechanistic Flows with regulons in program Pr-76

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ATMup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MACF1up-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PTPRDup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Callup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Callup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_Callup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)up-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)up-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del13up-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del1pup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticup-regulatesSREBF1activatesR-11401.672846Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ATMup-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAT2up-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

NRASdown-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Callup-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_Callup-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)up-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SYNE2up-regulatesETS1activatesR-92.772316Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DIS3down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAM46Cup-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PRKD2down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(11;14)down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Calldown-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Calldown-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_Calldown-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

TP53down-regulatesSRFrepressesR-17913.927867Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DNAH10up-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

NRASdown-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PRDM1up-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Callup-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Callup-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_Callup-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)up-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

TP53up-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticup-regulatesNFIAactivatesR-3554.100517Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DIS3down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DSTdown-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAT3down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

IRF4down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MACF1down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MAXdown-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PRKD2down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Calldown-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)down-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qdown-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticdown-regulatesVDRrepressesR-12315.128166Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ATMup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DCHS1up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DIS3up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAT1up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FGFR3up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MAXup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RELNup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Callup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Callup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_Callup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ROBO1down-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del13up-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticup-regulatesMAFactivatesR-1065.508259Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DCHS1down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

DIS3down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAM46Cup-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FGFR3down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

NRASup-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RELNdown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_Calldown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_Calldown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SETD2down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

TRIOdown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

amp1qdown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

del13down-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)_cytogeneticdown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)_cytogeneticdown-regulatesMZF1repressesR-30246.080418Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

Regulons in program Pr-76

Regulon Cox Hazard Ratio # genes # causal flows
R-11401.67284613
R-92.7723167
R-17913.92786710
R-3554.1005179
R-12315.12816612
R-1065.50825917
R-30246.08041816

Genes in program Pr-76

EnsEMBL IdEntrez IdPreferred
ENSG00000205832

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions