Program

Causal Mechanistic Flows with regulons in program Pr-62

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FAM46Cdown-regulatesMAZactivatesR-5100.3068137Pr-62
NRASdown-regulatesMAZactivatesR-5100.3068137Pr-62
PRKD2up-regulatesMAZactivatesR-5100.3068137Pr-62
TRAF3up-regulatesMAZactivatesR-5100.3068137Pr-62
BAI3up-regulatesHMBOX1activatesR-23820.3781786Pr-62
CMYA5down-regulatesHMBOX1activatesR-23820.3781786Pr-62
DMDup-regulatesHMBOX1activatesR-23820.3781786Pr-62
DNAH5down-regulatesHMBOX1activatesR-23820.3781786Pr-62
FGFR3up-regulatesHMBOX1activatesR-23820.3781786Pr-62
IRF4up-regulatesHMBOX1activatesR-23820.3781786Pr-62
KLHL6down-regulatesHMBOX1activatesR-23820.3781786Pr-62
MACF1down-regulatesHMBOX1activatesR-23820.3781786Pr-62
MPDZup-regulatesHMBOX1activatesR-23820.3781786Pr-62
OBSCNdown-regulatesHMBOX1activatesR-23820.3781786Pr-62
PCDH10down-regulatesHMBOX1activatesR-23820.3781786Pr-62
PKHD1up-regulatesHMBOX1activatesR-23820.3781786Pr-62
PKHD1L1down-regulatesHMBOX1activatesR-23820.3781786Pr-62
PRDM1up-regulatesHMBOX1activatesR-23820.3781786Pr-62
t(11;14)up-regulatesHMBOX1activatesR-23820.3781786Pr-62
RNASeq_CCND3_Callup-regulatesHMBOX1activatesR-23820.3781786Pr-62
RNASeq_MAFB_Callup-regulatesHMBOX1activatesR-23820.3781786Pr-62
SYNE2down-regulatesHMBOX1activatesR-23820.3781786Pr-62
TRIOup-regulatesHMBOX1activatesR-23820.3781786Pr-62
del17down-regulatesHMBOX1activatesR-23820.3781786Pr-62
del17pdown-regulatesHMBOX1activatesR-23820.3781786Pr-62
t(11;14)_cytogeneticup-regulatesHMBOX1activatesR-23820.3781786Pr-62
DMDdown-regulatesETV2repressesR-15110.4475426Pr-62
IRF4down-regulatesETV2repressesR-15110.4475426Pr-62
t(11;14)down-regulatesETV2repressesR-15110.4475426Pr-62
RNASeq_CCND3_Calldown-regulatesETV2repressesR-15110.4475426Pr-62
t(11;14)_cytogeneticdown-regulatesETV2repressesR-15110.4475426Pr-62
KIAA1109down-regulatesNF1activatesR-126-0.8810567Pr-62
t(11;14)up-regulatesNF1activatesR-126-0.8810567Pr-62
RNASeq_CCND3_Callup-regulatesNF1activatesR-126-0.8810567Pr-62
t(11;14)_cytogeneticup-regulatesNF1activatesR-126-0.8810567Pr-62
RNASeq_MAFA_Callup-regulatesZNF691activatesR-30080.9097138Pr-62
TP53up-regulatesZNF691activatesR-30080.9097138Pr-62
ASXL3down-regulatesRORArepressesR-22800.9146026Pr-62
t(11;14)down-regulatesRORArepressesR-22800.9146026Pr-62
amp1qup-regulatesRORArepressesR-22800.9146026Pr-62
del13up-regulatesRORArepressesR-22800.9146026Pr-62
DIS3up-regulatesIRF9activatesR-11510.92701618Pr-62
ROBO1down-regulatesIRF9activatesR-11510.92701618Pr-62
DIS3up-regulatesVENTXactivatesR-2116-1.021898Pr-62
t(11;14)up-regulatesVENTXactivatesR-2116-1.021898Pr-62
RNASeq_FGFR3_Calldown-regulatesVENTXactivatesR-2116-1.021898Pr-62
t(4;14)down-regulatesVENTXactivatesR-2116-1.021898Pr-62
t(11;14)_cytogeneticup-regulatesVENTXactivatesR-2116-1.021898Pr-62
t(14;16)_cytogeneticdown-regulatesVENTXactivatesR-2116-1.021898Pr-62
t(4;14)_cytogeneticdown-regulatesVENTXactivatesR-2116-1.021898Pr-62
DIS3down-regulatesENSG00000168269repressesR-15631.1026917Pr-62
IRF4down-regulatesENSG00000168269repressesR-15631.1026917Pr-62
t(11;14)down-regulatesENSG00000168269repressesR-15631.1026917Pr-62
t(4;14)up-regulatesENSG00000168269repressesR-15631.1026917Pr-62
t(11;14)_cytogeneticdown-regulatesENSG00000168269repressesR-15631.1026917Pr-62
COL12A1up-regulatesPOU2F2repressesR-25121.3781715Pr-62
FAT1up-regulatesPOU2F2repressesR-25121.3781715Pr-62
FGFR3up-regulatesPOU2F2repressesR-25121.3781715Pr-62
IRF4down-regulatesPOU2F2repressesR-25121.3781715Pr-62
KDM3Bdown-regulatesPOU2F2repressesR-25121.3781715Pr-62
KLHL6up-regulatesPOU2F2repressesR-25121.3781715Pr-62
t(11;14)down-regulatesPOU2F2repressesR-25121.3781715Pr-62
RNASeq_FGFR3_Callup-regulatesPOU2F2repressesR-25121.3781715Pr-62
t(4;14)up-regulatesPOU2F2repressesR-25121.3781715Pr-62
ROBO1up-regulatesPOU2F2repressesR-25121.3781715Pr-62
TP53down-regulatesPOU2F2repressesR-25121.3781715Pr-62
del13up-regulatesPOU2F2repressesR-25121.3781715Pr-62
t(11;14)_cytogeneticdown-regulatesPOU2F2repressesR-25121.3781715Pr-62
t(4;14)_cytogeneticup-regulatesPOU2F2repressesR-25121.3781715Pr-62
t(11;14)up-regulatesBORCS8-MEF2BactivatesR-9611.3818210Pr-62
RNASeq_CCND2_Callup-regulatesBORCS8-MEF2BactivatesR-9611.3818210Pr-62
t(11;14)_cytogeneticup-regulatesBORCS8-MEF2BactivatesR-9611.3818210Pr-62
RNASeq_MAFA_Calldown-regulatesELF2activatesR-9762.4061311Pr-62
DIS3up-regulatesSP1activatesR-27272.5314918Pr-62
FAM46Cdown-regulatesSP1activatesR-27272.5314918Pr-62
IRF4up-regulatesSP1activatesR-27272.5314918Pr-62
TRAF3up-regulatesSP1activatesR-27272.5314918Pr-62

Regulons in program Pr-62

Regulon Cox Hazard Ratio # genes # causal flows
R-5100.30681374
R-23820.378178622
R-15110.44754265
R-126-0.88105674
R-30080.90971382
R-22800.91460264
R-11510.927016182
R-2116-1.0218987
R-15631.10269175
R-25121.378171514
R-9611.38182103
R-9762.40613111
R-27272.53149184

Genes in program Pr-62

EnsEMBL IdEntrez IdPreferred
ENSG00000178498 196403DTX3
ENSG00000179388 1960EGR3
ENSG00000180530 8204NRIP1
ENSG00000186529 4051CYP4F3
ENSG00000186834 10614HEXIM1
ENSG00000186998
ENSG00000187147 55182RNF220
ENSG00000188529 10772SRSF10
ENSG00000196233 84458LCOR
ENSG00000198431 7296TXNRD1
ENSG00000198467 7169TPM2
ENSG00000269404 6689SPIB

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions