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Causal Mechanistic Flows with regulons in program Pr-68

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Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
AHNAK2	up-regulates	PARP1	activates	R-2636	8.12838	12	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	MYB	activates	R-614	8.54513	43	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F2	activates	R-2942	8.59906	19	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F8	activates	R-1626	8.62493	33	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F1	activates	R-2173	8.76486	19	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F1	activates	R-2172	8.82921	52	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F2	activates	R-2944	8.90615	10	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	up-regulates	E2F8	activates	R-1627	9.26408	11	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
amp1q	up-regulates	E2F2	activates	R-2944	8.90615	10	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627

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Regulons in program Pr-68

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Regulon	Cox Hazard Ratio	# genes	# causal flows
R-2944	8.90615	10	28
R-2942	8.59906	19	18
R-2636	8.12838	12	16
R-2518	8.01545	6	5
R-2319	7.33249	7	5
R-2173	8.76486	19	19
R-2172	8.82921	52	20
R-2046	8.47287	50	2
R-2043	8.36323	138	1
R-1931	8.29917	16	1

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Genes in program Pr-68