Program

Causal Mechanistic Flows with regulons in program Pr-104

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MAXdown-regulatesTP53repressesR-374-0.2892828Pr-104
t(14;16)down-regulatesTP53repressesR-374-0.2892828Pr-104
SYNE1up-regulatesTP53repressesR-374-0.2892828Pr-104
del13down-regulatesTP53repressesR-374-0.2892828Pr-104
t(4;14)up-regulatesNFYAactivatesR-1474-2.2968611Pr-104
DIS3up-regulatesSATB1repressesR-1081-2.381956Pr-104
MAXdown-regulatesSATB1repressesR-1081-2.381956Pr-104
PRKD2up-regulatesSATB1repressesR-1081-2.381956Pr-104
FGFR3up-regulatesPOU2F2activatesR-2519-3.133556Pr-104
HUWE1down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
IRF4down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
KDM3Bdown-regulatesPOU2F2activatesR-2519-3.133556Pr-104
KLHL6up-regulatesPOU2F2activatesR-2519-3.133556Pr-104
MXRA5down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
NRASdown-regulatesPOU2F2activatesR-2519-3.133556Pr-104
t(11;14)down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
RNASeq_FGFR3_Callup-regulatesPOU2F2activatesR-2519-3.133556Pr-104
RNASeq_MAFA_Calldown-regulatesPOU2F2activatesR-2519-3.133556Pr-104
RNASeq_MAFB_Calldown-regulatesPOU2F2activatesR-2519-3.133556Pr-104
t(14;16)down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
t(4;14)up-regulatesPOU2F2activatesR-2519-3.133556Pr-104
ROBO1up-regulatesPOU2F2activatesR-2519-3.133556Pr-104
TP53down-regulatesPOU2F2activatesR-2519-3.133556Pr-104
t(11;14)_cytogeneticdown-regulatesPOU2F2activatesR-2519-3.133556Pr-104
t(4;14)_cytogeneticup-regulatesPOU2F2activatesR-2519-3.133556Pr-104
FAT3down-regulatesZNF281activatesR-2496-3.64947Pr-104
amp1qup-regulatesZNF281activatesR-2496-3.64947Pr-104
del13up-regulatesZNF281activatesR-2496-3.64947Pr-104
IRF4down-regulatesNR3C1activatesR-3191-3.9519710Pr-104
t(11;14)down-regulatesNR3C1activatesR-3191-3.9519710Pr-104
RNASeq_CCND2_Calldown-regulatesNR3C1activatesR-3191-3.9519710Pr-104
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3191-3.9519710Pr-104
DIS3down-regulatesHMGA1activatesR-828-4.345897Pr-104
IRF4down-regulatesHMGA1activatesR-828-4.345897Pr-104
NEBup-regulatesHMGA1activatesR-828-4.345897Pr-104
t(11;14)down-regulatesHMGA1activatesR-828-4.345897Pr-104
RNASeq_CCND3_Calldown-regulatesHMGA1activatesR-828-4.345897Pr-104
ROBO1up-regulatesHMGA1activatesR-828-4.345897Pr-104
t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-828-4.345897Pr-104
BRAFup-regulatesZNF219repressesR-2215-4.809678Pr-104
DIS3up-regulatesZNF219repressesR-2215-4.809678Pr-104
FAM46Cdown-regulatesZNF219repressesR-2215-4.809678Pr-104
IRF4up-regulatesZNF219repressesR-2215-4.809678Pr-104
t(11;14)up-regulatesZNF219repressesR-2215-4.809678Pr-104
t(11;14)_cytogeneticup-regulatesZNF219repressesR-2215-4.809678Pr-104
DIS3up-regulatesSREBF1repressesR-1138-5.226078Pr-104
IRF4up-regulatesSREBF1repressesR-1138-5.226078Pr-104
t(11;14)up-regulatesSREBF1repressesR-1138-5.226078Pr-104
RNASeq_MAFA_Callup-regulatesSREBF1repressesR-1138-5.226078Pr-104
RNASeq_MAFB_Callup-regulatesSREBF1repressesR-1138-5.226078Pr-104
t(14;16)up-regulatesSREBF1repressesR-1138-5.226078Pr-104
t(11;14)_cytogeneticup-regulatesSREBF1repressesR-1138-5.226078Pr-104
DIS3down-regulatesSRFactivatesR-1787-5.2907419Pr-104
DNAH10down-regulatesSRFactivatesR-1787-5.2907419Pr-104
FAM46Cup-regulatesSRFactivatesR-1787-5.2907419Pr-104
FRAS1down-regulatesSRFactivatesR-1787-5.2907419Pr-104
IRF4down-regulatesSRFactivatesR-1787-5.2907419Pr-104
MXRA5down-regulatesSRFactivatesR-1787-5.2907419Pr-104
t(11;14)down-regulatesSRFactivatesR-1787-5.2907419Pr-104
RNASeq_MAFA_Calldown-regulatesSRFactivatesR-1787-5.2907419Pr-104
RNASeq_MAFB_Calldown-regulatesSRFactivatesR-1787-5.2907419Pr-104
t(14;16)down-regulatesSRFactivatesR-1787-5.2907419Pr-104
MYCdown-regulatesSRFactivatesR-1787-5.2907419Pr-104
TP53down-regulatesSRFactivatesR-1787-5.2907419Pr-104
ZNF462down-regulatesSRFactivatesR-1787-5.2907419Pr-104
IRF4up-regulatesMYBrepressesR-621-5.472468Pr-104
t(11;14)up-regulatesMYBrepressesR-621-5.472468Pr-104
RNASeq_MAFA_Callup-regulatesMYBrepressesR-621-5.472468Pr-104
RNASeq_MAFB_Callup-regulatesMYBrepressesR-621-5.472468Pr-104
t(14;16)up-regulatesMYBrepressesR-621-5.472468Pr-104
TP53up-regulatesMYBrepressesR-621-5.472468Pr-104
t(11;14)_cytogeneticup-regulatesMYBrepressesR-621-5.472468Pr-104
DIS3up-regulatesSP1repressesR-2720-6.0235428Pr-104
FAM46Cdown-regulatesSP1repressesR-2720-6.0235428Pr-104
IRF4up-regulatesSP1repressesR-2720-6.0235428Pr-104
RNASeq_MAFA_Callup-regulatesSP1repressesR-2720-6.0235428Pr-104
RNASeq_MAFB_Callup-regulatesSP1repressesR-2720-6.0235428Pr-104
t(14;16)up-regulatesSP1repressesR-2720-6.0235428Pr-104
ROBO2up-regulatesSP1repressesR-2720-6.0235428Pr-104
TRIOup-regulatesSP1repressesR-2720-6.0235428Pr-104
TTNup-regulatesSP1repressesR-2720-6.0235428Pr-104
ZNF462up-regulatesSP1repressesR-2720-6.0235428Pr-104
amp1qup-regulatesSP1repressesR-2720-6.0235428Pr-104

Regulons in program Pr-104

Regulon Cox Hazard Ratio # genes # causal flows
R-374-0.28928284
R-1474-2.29686111
R-1081-2.3819563
R-2519-3.13355617
R-2496-3.649473
R-3191-3.95197104
R-828-4.3458977
R-2215-4.8096786
R-1138-5.2260787
R-1787-5.290741913
R-621-5.4724687
R-2720-6.023542811

Genes in program Pr-104

EnsEMBL IdEntrez IdPreferred
ENSG00000178163 85460ZNF518B
ENSG00000255529 81488POLR2M
ENSG00000261857 8190MIA

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions