Program

Causal Mechanistic Flows with regulons in program Pr-59

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
amp1qup-regulatesFOXP1repressesR-3140-0.014358710Pr-59
del13up-regulatesFOXP1repressesR-3140-0.014358710Pr-59
NEBdown-regulatesPRDM1repressesR-20800.51764211Pr-59
RNASeq_FGFR3_Callup-regulatesPRDM1repressesR-20800.51764211Pr-59
t(4;14)up-regulatesPRDM1repressesR-20800.51764211Pr-59
amp1qup-regulatesPRDM1repressesR-20800.51764211Pr-59
del13up-regulatesPRDM1repressesR-20800.51764211Pr-59
del1pup-regulatesPRDM1repressesR-20800.51764211Pr-59
FAM46Cdown-regulatesNFYCactivatesR-298-0.6604637Pr-59
IRF4up-regulatesNFYCactivatesR-298-0.6604637Pr-59
NRASdown-regulatesNFYCactivatesR-298-0.6604637Pr-59
t(11;14)up-regulatesNFYCactivatesR-298-0.6604637Pr-59
amp1qdown-regulatesNFYCactivatesR-298-0.6604637Pr-59
t(11;14)_cytogeneticup-regulatesNFYCactivatesR-298-0.6604637Pr-59
ATMdown-regulatesFLI1activatesR-786-0.73339410Pr-59
MAXdown-regulatesFLI1activatesR-786-0.73339410Pr-59
NRASup-regulatesFLI1activatesR-786-0.73339410Pr-59
PTPRTdown-regulatesFLI1activatesR-786-0.73339410Pr-59
RNASeq_MAFA_Calldown-regulatesFLI1activatesR-786-0.73339410Pr-59
t(14;16)down-regulatesFLI1activatesR-786-0.73339410Pr-59
TRAF3down-regulatesFLI1activatesR-786-0.73339410Pr-59
TTNdown-regulatesFLI1activatesR-786-0.73339410Pr-59
amp1qdown-regulatesFLI1activatesR-786-0.73339410Pr-59
del13down-regulatesFLI1activatesR-786-0.73339410Pr-59
t(14;16)_cytogeneticdown-regulatesFLI1activatesR-786-0.73339410Pr-59
AHNAK2up-regulatesMYBrepressesR-619-0.78142510Pr-59
MACF1up-regulatesMYBrepressesR-619-0.78142510Pr-59
NRASdown-regulatesMYBrepressesR-619-0.78142510Pr-59
t(14;16)up-regulatesMYBrepressesR-619-0.78142510Pr-59
t(4;14)up-regulatesMYBrepressesR-619-0.78142510Pr-59
amp1qup-regulatesMYBrepressesR-619-0.78142510Pr-59
del13up-regulatesMYBrepressesR-619-0.78142510Pr-59
t(14;16)_cytogeneticup-regulatesMYBrepressesR-619-0.78142510Pr-59
t(11;14)up-regulatesNFYAactivatesR-1472-0.79888114Pr-59
amp1qup-regulatesCEBPGrepressesR-450-0.8104067Pr-59
del13up-regulatesCEBPGrepressesR-450-0.8104067Pr-59
KIAA1109up-regulatesARID5ArepressesR-6010.90014610Pr-59
amp1qup-regulatesARID5ArepressesR-6010.90014610Pr-59
AHNAK2down-regulatesRREB1repressesR-23011.039028Pr-59
FAM46Cup-regulatesENSG00000168269repressesR-15641.2801917Pr-59
MYO10down-regulatesENSG00000168269repressesR-15641.2801917Pr-59
t(11;14)down-regulatesENSG00000168269repressesR-15641.2801917Pr-59
RNASeq_MAFB_Calldown-regulatesENSG00000168269repressesR-15641.2801917Pr-59
SDK1down-regulatesENSG00000168269repressesR-15641.2801917Pr-59
TACC2down-regulatesENSG00000168269repressesR-15641.2801917Pr-59
t(11;14)_cytogeneticdown-regulatesENSG00000168269repressesR-15641.2801917Pr-59
t(14;16)up-regulatesELK1repressesR-654-1.311246Pr-59
TACC2down-regulatesELK1repressesR-654-1.311246Pr-59
amp1qup-regulatesELK1repressesR-654-1.311246Pr-59
del13up-regulatesELK1repressesR-654-1.311246Pr-59
del1pup-regulatesELK1repressesR-654-1.311246Pr-59
CYLDup-regulatesFOSL1repressesR-27951.6001110Pr-59
FGFR3down-regulatesFOSL1repressesR-27951.6001110Pr-59
RNASeq_FGFR3_Calldown-regulatesFOSL1repressesR-27951.6001110Pr-59
t(4;14)down-regulatesFOSL1repressesR-27951.6001110Pr-59
t(4;14)_cytogeneticdown-regulatesFOSL1repressesR-27951.6001110Pr-59
RNASeq_FGFR3_Callup-regulatesFOXJ3repressesR-2891-1.6870413Pr-59
t(4;14)up-regulatesFOXJ3repressesR-2891-1.6870413Pr-59
amp1qup-regulatesFOXJ3repressesR-2891-1.6870413Pr-59
del13up-regulatesFOXJ3repressesR-2891-1.6870413Pr-59
RNASeq_MAFA_Calldown-regulatesXBP1activatesR-3058-2.245638Pr-59
MYCdown-regulatesXBP1activatesR-3058-2.245638Pr-59
del1pdown-regulatesXBP1activatesR-3058-2.245638Pr-59
t(11;14)down-regulatesSOX4repressesR-2183-2.3572110Pr-59
RNASeq_MAFB_Calldown-regulatesSOX4repressesR-2183-2.3572110Pr-59
t(14;16)down-regulatesSOX4repressesR-2183-2.3572110Pr-59
SYNE2down-regulatesSOX4repressesR-2183-2.3572110Pr-59
t(11;14)_cytogeneticdown-regulatesSOX4repressesR-2183-2.3572110Pr-59
BAI3down-regulatesETV2repressesR-15082.56349Pr-59
DIS3down-regulatesETV2repressesR-15082.56349Pr-59
FAM46Cup-regulatesETV2repressesR-15082.56349Pr-59
IRF4down-regulatesETV2repressesR-15082.56349Pr-59
KDM3Bdown-regulatesETV2repressesR-15082.56349Pr-59
MAXdown-regulatesETV2repressesR-15082.56349Pr-59
t(11;14)down-regulatesETV2repressesR-15082.56349Pr-59
t(4;14)down-regulatesETV2repressesR-15082.56349Pr-59
TRAF3down-regulatesETV2repressesR-15082.56349Pr-59
t(11;14)_cytogeneticdown-regulatesETV2repressesR-15082.56349Pr-59
t(14;16)up-regulatesNRF1repressesR-2708-2.688699Pr-59
amp1qup-regulatesNRF1repressesR-2708-2.688699Pr-59
del13up-regulatesNRF1repressesR-2708-2.688699Pr-59
t(11;14)down-regulatesPITX1repressesR-658-3.0434511Pr-59
t(11;14)_cytogeneticdown-regulatesPITX1repressesR-658-3.0434511Pr-59

Regulons in program Pr-59

Regulon Cox Hazard Ratio # genes # causal flows
R-3140-0.0143587102
R-20800.517642116
R-298-0.66046376
R-786-0.7333941011
R-619-0.781425108
R-1472-0.798881141
R-450-0.81040672
R-6010.900146102
R-23011.0390281
R-15641.28019177
R-654-1.3112465
R-27951.60011105
R-2891-1.68704134
R-3058-2.2456383
R-2183-2.35721105
R-15082.5634910
R-2708-2.6886993
R-658-3.04345112

Genes in program Pr-59

EnsEMBL IdEntrez IdPreferred
ENSG00000175550 10589DRAP1
ENSG00000181610 51649MRPS23
ENSG00000183741 23466CBX6
ENSG00000184752 55967NDUFA12
ENSG00000185262 283991UBALD2
ENSG00000185499 4582MUC1
ENSG00000185630 5087PBX1
ENSG00000186806
ENSG00000188783 5549PRELP
ENSG00000197766 1675CFD
ENSG00000197965 9019MPZL1
ENSG00000204634 11138TBC1D8
ENSG00000211455 23012STK38L
ENSG00000253485 56110PCDHGA5
ENSG00000259075 100528030POC1B-GALNT4

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions