Program

Causal Mechanistic Flows with regulons in program Pr-91

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
NEBdown-regulatesFOXK1repressesR-1211-1.321957Pr-91
t(4;14)up-regulatesFOXK1repressesR-1211-1.321957Pr-91
MXRA5down-regulatesSP3activatesR-1821-1.4883210Pr-91
NRASdown-regulatesSP3activatesR-1821-1.4883210Pr-91
RNASeq_MAFB_Callup-regulatesSP3activatesR-1821-1.4883210Pr-91
t(14;16)up-regulatesSP3activatesR-1821-1.4883210Pr-91
TRAF3up-regulatesSP3activatesR-1821-1.4883210Pr-91
del13up-regulatesSP3activatesR-1821-1.4883210Pr-91
MXRA5down-regulatesSP3activatesR-1822-1.742988Pr-91
NRASdown-regulatesSP3activatesR-1822-1.742988Pr-91
t(4;14)up-regulatesSP3activatesR-1822-1.742988Pr-91
SVILup-regulatesSP3activatesR-1822-1.742988Pr-91
TRAF3up-regulatesSP3activatesR-1822-1.742988Pr-91
del13up-regulatesSP3activatesR-1822-1.742988Pr-91
FAT3down-regulatesNFKB1activatesR-1580-1.8192515Pr-91
MAXdown-regulatesNFKB1activatesR-1580-1.8192515Pr-91
RNASeq_FGFR3_Calldown-regulatesNFKB1activatesR-1580-1.8192515Pr-91
t(4;14)down-regulatesNFKB1activatesR-1580-1.8192515Pr-91
t(4;14)_cytogeneticdown-regulatesNFKB1activatesR-1580-1.8192515Pr-91
ATMdown-regulatesHMGA1repressesR-824-1.9793219Pr-91
NRASup-regulatesHMGA1repressesR-824-1.9793219Pr-91
RNASeq_MAFA_Calldown-regulatesHMGA1repressesR-824-1.9793219Pr-91
RNASeq_MAFB_Calldown-regulatesHMGA1repressesR-824-1.9793219Pr-91
t(14;16)down-regulatesHMGA1repressesR-824-1.9793219Pr-91
FGFR3down-regulatesSOX7activatesR-1298-2.0128923Pr-91
PRKD2down-regulatesSOX7activatesR-1298-2.0128923Pr-91
RNASeq_FGFR3_Calldown-regulatesSOX7activatesR-1298-2.0128923Pr-91
t(4;14)down-regulatesSOX7activatesR-1298-2.0128923Pr-91
t(4;14)_cytogeneticdown-regulatesSOX7activatesR-1298-2.0128923Pr-91
CYLDdown-regulatesTCF3repressesR-2056-2.1154629Pr-91
MAXup-regulatesTCF3repressesR-2056-2.1154629Pr-91
NFKB2down-regulatesTCF3repressesR-2056-2.1154629Pr-91
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-2056-2.1154629Pr-91
t(14;16)down-regulatesTCF3repressesR-2056-2.1154629Pr-91
ZNF208up-regulatesTCF3repressesR-2056-2.1154629Pr-91
t(14;16)up-regulatesRUNX3activatesR-896-2.1666912Pr-91
t(11;14)_cytogeneticup-regulatesRUNX3activatesR-896-2.1666912Pr-91
del13up-regulatesRORAactivatesR-2268-2.4255814Pr-91
NFKB2up-regulatesIRF7activatesR-1085-2.5147516Pr-91
RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1085-2.5147516Pr-91
t(4;14)down-regulatesIRF7activatesR-1085-2.5147516Pr-91
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1085-2.5147516Pr-91
CYLDup-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
FAT2up-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
FGFR3down-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
MAXdown-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
NFKB2up-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
NRASdown-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
PRKD2down-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
t(11;14)down-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
RNASeq_CCND2_Calldown-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
RNASeq_FGFR3_Calldown-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
RNASeq_MAFA_Callup-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
t(14;16)up-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
t(4;14)down-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
t(4;14)_cytogeneticdown-regulatesENSG00000177374activatesR-2362-2.7831511Pr-91
CACNA1Hup-regulatesNR3C1activatesR-3186-2.9313515Pr-91
CYLDup-regulatesNR3C1activatesR-3186-2.9313515Pr-91
IRF4down-regulatesNR3C1activatesR-3186-2.9313515Pr-91
KIAA1244up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
MYO10up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
NFKB2up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
NRASdown-regulatesNR3C1activatesR-3186-2.9313515Pr-91
PRKD2down-regulatesNR3C1activatesR-3186-2.9313515Pr-91
t(11;14)down-regulatesNR3C1activatesR-3186-2.9313515Pr-91
SP140up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
SYNE2up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
TRAF3up-regulatesNR3C1activatesR-3186-2.9313515Pr-91
del13up-regulatesNR3C1activatesR-3186-2.9313515Pr-91

Regulons in program Pr-91

Regulon Cox Hazard Ratio # genes # causal flows
R-1211-1.3219572
R-1821-1.48832106
R-1822-1.7429886
R-1580-1.81925155
R-824-1.97932195
R-1298-2.01289235
R-2056-2.11546296
R-896-2.16669122
R-2268-2.42558141
R-1085-2.51475164
R-2362-2.783151114
R-3186-2.931351513

Genes in program Pr-91

EnsEMBL IdEntrez IdPreferred
ENSG00000198046 63934ZNF667
ENSG00000198919 9666DZIP3
ENSG00000213593 51075TMX2
ENSG00000214413 92482BBIP1
ENSG00000228300 55009C19orf24
ENSG00000231389 3113HLA-DPA1
ENSG00000242550 5273SERPINB10
ENSG00000244165 5032P2RY11
ENSG00000082641 4779NFE2L1
ENSG00000276561 3665IRF7

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions