Program

Causal Mechanistic Flows with regulons in program Pr-2

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
del13up-regulatesUSF1activatesR-1855-0.057076111Pr-2
t(11;14)_cytogeneticup-regulatesUSF1activatesR-1855-0.057076111Pr-2
AHNAK2down-regulatesRORAactivatesR-2267-0.065542416Pr-2
BRAFup-regulatesRORAactivatesR-2267-0.065542416Pr-2
del13up-regulatesRORAactivatesR-2267-0.065542416Pr-2
AHNAK2down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
CMYA5down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
FAT3down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
MACF1down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
NEBdown-regulatesTRAF4activatesR-3037-0.069899716Pr-2
PCDH10down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
PTPRDdown-regulatesTRAF4activatesR-3037-0.069899716Pr-2
t(11;14)up-regulatesTRAF4activatesR-3037-0.069899716Pr-2
RNASeq_MAFB_Calldown-regulatesTRAF4activatesR-3037-0.069899716Pr-2
TACC2down-regulatesTRAF4activatesR-3037-0.069899716Pr-2
AHNAK2down-regulatesDDIT3activatesR-486-0.07965637Pr-2
CMYA5down-regulatesDDIT3activatesR-486-0.07965637Pr-2
MYO10down-regulatesDDIT3activatesR-486-0.07965637Pr-2
NEBdown-regulatesDDIT3activatesR-486-0.07965637Pr-2
t(11;14)up-regulatesDDIT3activatesR-486-0.07965637Pr-2
amp1qup-regulatesDDIT3activatesR-486-0.07965637Pr-2
del13up-regulatesDDIT3activatesR-486-0.07965637Pr-2
t(11;14)_cytogeneticup-regulatesDDIT3activatesR-486-0.07965637Pr-2
AHNAK2up-regulatesSP1repressesR-2717-0.094882432Pr-2
PTPRDup-regulatesSP1repressesR-2717-0.094882432Pr-2
RNASeq_MAFA_Callup-regulatesSP1repressesR-2717-0.094882432Pr-2
RNASeq_MAFB_Callup-regulatesSP1repressesR-2717-0.094882432Pr-2
amp1qup-regulatesMEF2DactivatesR-8780.1017346Pr-2
del13up-regulatesMEF2DactivatesR-8780.1017346Pr-2
t(11;14)down-regulatesTP53repressesR-3630.10382916Pr-2
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3630.10382916Pr-2
t(4;14)down-regulatesTP53repressesR-3630.10382916Pr-2
SYNE1up-regulatesTP53repressesR-3630.10382916Pr-2
amp1qdown-regulatesTP53repressesR-3630.10382916Pr-2
del13down-regulatesTP53repressesR-3630.10382916Pr-2
AHNAK2up-regulatesVBP1repressesR-2104-0.1541866Pr-2
CMYA5up-regulatesVBP1repressesR-2104-0.1541866Pr-2
MACF1up-regulatesVBP1repressesR-2104-0.1541866Pr-2
MYO10up-regulatesVBP1repressesR-2104-0.1541866Pr-2
NEBup-regulatesVBP1repressesR-2104-0.1541866Pr-2
PTPRDup-regulatesVBP1repressesR-2104-0.1541866Pr-2
RNASeq_MAFA_Callup-regulatesVBP1repressesR-2104-0.1541866Pr-2
SYNE1up-regulatesVBP1repressesR-2104-0.1541866Pr-2
TACC2up-regulatesVBP1repressesR-2104-0.1541866Pr-2
del13down-regulatesVBP1repressesR-2104-0.1541866Pr-2
del17up-regulatesVBP1repressesR-2104-0.1541866Pr-2
del17pup-regulatesVBP1repressesR-2104-0.1541866Pr-2
t(14;16)_cytogeneticup-regulatesVBP1repressesR-2104-0.1541866Pr-2
AHNAK2up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
CMYA5up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
FAT3up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
MACF1up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
NEBup-regulatesZSCAN16repressesR-631-0.1655966Pr-2
PCDH10up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
PTPRDup-regulatesZSCAN16repressesR-631-0.1655966Pr-2
t(11;14)down-regulatesZSCAN16repressesR-631-0.1655966Pr-2
t(4;14)down-regulatesZSCAN16repressesR-631-0.1655966Pr-2
SYNE1up-regulatesZSCAN16repressesR-631-0.1655966Pr-2
del13down-regulatesZSCAN16repressesR-631-0.1655966Pr-2
AHNAK2down-regulatesNR3C1activatesR-3178-0.17304624Pr-2
PCDH10down-regulatesNR3C1activatesR-3178-0.17304624Pr-2
t(14;16)up-regulatesNR3C1activatesR-3178-0.17304624Pr-2
del13up-regulatesNR3C1activatesR-3178-0.17304624Pr-2
AHNAK2up-regulatesATF1repressesR-5630.21933513Pr-2
PCDH10up-regulatesATF1repressesR-5630.21933513Pr-2
FAT3up-regulatesNFE2L2repressesR-1911-0.24623912Pr-2
MACF1up-regulatesNFE2L2repressesR-1911-0.24623912Pr-2
amp1qdown-regulatesNFE2L2repressesR-1911-0.24623912Pr-2
del13down-regulatesNFE2L2repressesR-1911-0.24623912Pr-2
AHNAK2down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
FAT3down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
MACF1down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
MYO10down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
NEBdown-regulatesCEBPGactivatesR-436-0.25864519Pr-2
PCDH10down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
PTPRDdown-regulatesCEBPGactivatesR-436-0.25864519Pr-2
RNASeq_MAFA_Calldown-regulatesCEBPGactivatesR-436-0.25864519Pr-2
SYNE1down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
TACC2down-regulatesCEBPGactivatesR-436-0.25864519Pr-2
amp1qup-regulatesCEBPGactivatesR-436-0.25864519Pr-2
del13up-regulatesCEBPGactivatesR-436-0.25864519Pr-2
AHNAK2down-regulatesIRF1activatesR-183-0.26189329Pr-2
t(11;14)up-regulatesIRF1activatesR-183-0.26189329Pr-2
t(14;16)up-regulatesIRF1activatesR-183-0.26189329Pr-2
t(11;14)_cytogeneticup-regulatesIRF1activatesR-183-0.26189329Pr-2
AHNAK2down-regulatesELF1activatesR-2977-0.27217321Pr-2
PCDH10down-regulatesELF1activatesR-2977-0.27217321Pr-2
t(11;14)up-regulatesELF1activatesR-2977-0.27217321Pr-2
t(11;14)_cytogeneticup-regulatesELF1activatesR-2977-0.27217321Pr-2
AHNAK2down-regulatesPOU2F1activatesR-78-0.27241833Pr-2
CMYA5down-regulatesPOU2F1activatesR-78-0.27241833Pr-2
FAT3down-regulatesPOU2F1activatesR-78-0.27241833Pr-2
MACF1down-regulatesPOU2F1activatesR-78-0.27241833Pr-2
NEBdown-regulatesPOU2F1activatesR-78-0.27241833Pr-2
PTPRDdown-regulatesPOU2F1activatesR-78-0.27241833Pr-2
t(11;14)up-regulatesPOU2F1activatesR-78-0.27241833Pr-2
TACC2down-regulatesPOU2F1activatesR-78-0.27241833Pr-2
amp1qup-regulatesPOU2F1activatesR-78-0.27241833Pr-2
del13up-regulatesPOU2F1activatesR-78-0.27241833Pr-2
t(11;14)_cytogeneticup-regulatesPOU2F1activatesR-78-0.27241833Pr-2
AHNAK2down-regulatesZNF281activatesR-2479-0.33336823Pr-2
CMYA5down-regulatesZNF281activatesR-2479-0.33336823Pr-2
MACF1down-regulatesZNF281activatesR-2479-0.33336823Pr-2
NEBdown-regulatesZNF281activatesR-2479-0.33336823Pr-2
PCDH10down-regulatesZNF281activatesR-2479-0.33336823Pr-2
PTPRDdown-regulatesZNF281activatesR-2479-0.33336823Pr-2
t(11;14)up-regulatesZNF281activatesR-2479-0.33336823Pr-2
RNASeq_MAFB_Calldown-regulatesZNF281activatesR-2479-0.33336823Pr-2
t(4;14)up-regulatesZNF281activatesR-2479-0.33336823Pr-2
SYNE1down-regulatesZNF281activatesR-2479-0.33336823Pr-2
TACC2down-regulatesZNF281activatesR-2479-0.33336823Pr-2
del13up-regulatesZNF281activatesR-2479-0.33336823Pr-2
t(11;14)_cytogeneticup-regulatesZNF281activatesR-2479-0.33336823Pr-2
AHNAK2down-regulatesATF3activatesR-24110.3395297Pr-2
CMYA5down-regulatesATF3activatesR-24110.3395297Pr-2
RNASeq_FGFR3_Callup-regulatesATF3activatesR-24110.3395297Pr-2
RNASeq_MAFB_Calldown-regulatesATF3activatesR-24110.3395297Pr-2
t(4;14)up-regulatesATF3activatesR-24110.3395297Pr-2
SYNE1down-regulatesATF3activatesR-24110.3395297Pr-2
RNASeq_MAFB_Callup-regulatesNFE2L1repressesR-1825-0.3436098Pr-2
AHNAK2down-regulatesHSF1activatesR-49-0.35025215Pr-2
FAT3down-regulatesHSF1activatesR-49-0.35025215Pr-2
MACF1down-regulatesHSF1activatesR-49-0.35025215Pr-2
NEBdown-regulatesHSF1activatesR-49-0.35025215Pr-2
RNASeq_MAFB_Calldown-regulatesHSF1activatesR-49-0.35025215Pr-2
SYNE1down-regulatesHSF1activatesR-49-0.35025215Pr-2
TACC2down-regulatesHSF1activatesR-49-0.35025215Pr-2
del13up-regulatesHSF1activatesR-49-0.35025215Pr-2
AHNAK2down-regulatesCREB1activatesR-2720.36697411Pr-2
CMYA5down-regulatesCREB1activatesR-2720.36697411Pr-2
t(14;16)up-regulatesCREB1activatesR-2720.36697411Pr-2
amp1qup-regulatesCREB1activatesR-2720.36697411Pr-2
del13up-regulatesCREB1activatesR-2720.36697411Pr-2
SP140down-regulatesZNF740repressesR-390-0.3748817Pr-2
amp1qdown-regulatesZNF740repressesR-390-0.3748817Pr-2
del13down-regulatesZNF740repressesR-390-0.3748817Pr-2
AHNAK2down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
FAT3down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
MACF1down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
MYO10down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
RNASeq_MAFB_Calldown-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
SYNE1down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
TACC2down-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
amp1qup-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
del13up-regulatesMEF2AactivatesR-1869-0.39702233Pr-2
AHNAK2down-regulatesHBP1activatesR-1831-0.39754519Pr-2
MACF1down-regulatesHBP1activatesR-1831-0.39754519Pr-2
NEBdown-regulatesHBP1activatesR-1831-0.39754519Pr-2
PCDH10down-regulatesHBP1activatesR-1831-0.39754519Pr-2
t(11;14)up-regulatesHBP1activatesR-1831-0.39754519Pr-2
SYNE1down-regulatesHBP1activatesR-1831-0.39754519Pr-2
TACC2down-regulatesHBP1activatesR-1831-0.39754519Pr-2
amp1qup-regulatesHBP1activatesR-1831-0.39754519Pr-2
del13up-regulatesHBP1activatesR-1831-0.39754519Pr-2
NEBdown-regulatesIRX3activatesR-2225-0.39904413Pr-2
SYNE1down-regulatesIRX3activatesR-2225-0.39904413Pr-2
FAT3down-regulatesNFKB1activatesR-15860.401558Pr-2
SVILdown-regulatesNFKB1activatesR-15860.401558Pr-2
ZFHX3down-regulatesNFKB1activatesR-15860.401558Pr-2
RNASeq_FGFR3_Callup-regulatesCREB5activatesR-7750.44692412Pr-2
t(4;14)up-regulatesCREB5activatesR-7750.44692412Pr-2
amp1qup-regulatesCREB5activatesR-7750.44692412Pr-2
del13up-regulatesCREB5activatesR-7750.44692412Pr-2
t(4;14)_cytogeneticup-regulatesCREB5activatesR-7750.44692412Pr-2
NEBdown-regulatesBCL6activatesR-535-0.47832131Pr-2
t(11;14)up-regulatesBCL6activatesR-535-0.47832131Pr-2
SYNE1down-regulatesBCL6activatesR-535-0.47832131Pr-2
AHNAK2down-regulatesRFX3activatesR-1660-0.49581613Pr-2
CMYA5down-regulatesRFX3activatesR-1660-0.49581613Pr-2
MYO10down-regulatesRFX3activatesR-1660-0.49581613Pr-2
NEBdown-regulatesRFX3activatesR-1660-0.49581613Pr-2
t(11;14)up-regulatesRFX3activatesR-1660-0.49581613Pr-2
t(11;14)_cytogeneticup-regulatesRFX3activatesR-1660-0.49581613Pr-2
PTPRDdown-regulatesAHRactivatesR-7960.5191676Pr-2
del13up-regulatesAHRactivatesR-7960.5191676Pr-2
AHNAK2down-regulatesNFKB1activatesR-1574-0.53878430Pr-2
FAT3down-regulatesNFKB1activatesR-1574-0.53878430Pr-2
MACF1down-regulatesNFKB1activatesR-1574-0.53878430Pr-2
PCDH10down-regulatesNFKB1activatesR-1574-0.53878430Pr-2
RNASeq_MAFB_Calldown-regulatesNFKB1activatesR-1574-0.53878430Pr-2
TACC2down-regulatesNFKB1activatesR-1574-0.53878430Pr-2
PTPRDdown-regulatesENSG00000168269activatesR-1561-0.54791824Pr-2
RNASeq_MAFB_Calldown-regulatesENSG00000168269activatesR-1561-0.54791824Pr-2
t(4;14)up-regulatesENSG00000168269activatesR-1561-0.54791824Pr-2
TACC2down-regulatesENSG00000168269activatesR-1561-0.54791824Pr-2
AHNAK2down-regulatesFOXP1activatesR-3126-0.55565829Pr-2
DMDup-regulatesFOXP1activatesR-3126-0.55565829Pr-2
PCDH10down-regulatesFOXP1activatesR-3126-0.55565829Pr-2
PCDH7down-regulatesFOXP1activatesR-3126-0.55565829Pr-2
t(11;14)up-regulatesFOXP1activatesR-3126-0.55565829Pr-2
TACC2down-regulatesFOXP1activatesR-3126-0.55565829Pr-2
del13up-regulatesFOXP1activatesR-3126-0.55565829Pr-2
t(11;14)_cytogeneticup-regulatesFOXP1activatesR-3126-0.55565829Pr-2
MACF1up-regulatesZNF143repressesR-2309-0.58091214Pr-2
RNASeq_MAFA_Callup-regulatesZNF143repressesR-2309-0.58091214Pr-2
MYCup-regulatesZNF143repressesR-2309-0.58091214Pr-2
SYNE1up-regulatesZNF143repressesR-2309-0.58091214Pr-2
AHNAK2down-regulatesNR4A2activatesR-1717-0.58489310Pr-2
CMYA5down-regulatesNR4A2activatesR-1717-0.58489310Pr-2
FAT3down-regulatesNR4A2activatesR-1717-0.58489310Pr-2
MACF1down-regulatesNR4A2activatesR-1717-0.58489310Pr-2
TACC2down-regulatesNR4A2activatesR-1717-0.58489310Pr-2
AHNAK2down-regulatesRREB1activatesR-2283-0.61872822Pr-2
CMYA5down-regulatesRREB1activatesR-2283-0.61872822Pr-2
MACF1down-regulatesRREB1activatesR-2283-0.61872822Pr-2
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2283-0.61872822Pr-2
RNASeq_MAFB_Calldown-regulatesRREB1activatesR-2283-0.61872822Pr-2
SYNE1down-regulatesRREB1activatesR-2283-0.61872822Pr-2
TACC2down-regulatesRREB1activatesR-2283-0.61872822Pr-2
AHNAK2up-regulatesARID3ArepressesR-1341-0.64166518Pr-2
t(11;14)down-regulatesARID3ArepressesR-1341-0.64166518Pr-2
RNASeq_MAFA_Callup-regulatesARID3ArepressesR-1341-0.64166518Pr-2
PTPRDup-regulatesMIXL1repressesR-2662-0.661616Pr-2
t(14;16)down-regulatesMIXL1repressesR-2662-0.661616Pr-2
FAT3up-regulatesZNF691repressesR-3007-0.8164859Pr-2
TP53up-regulatesZNF691repressesR-3007-0.8164859Pr-2
AHNAK2down-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
ASXL3down-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
CMYA5down-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
PTPRDdown-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
t(11;14)up-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
t(4;14)up-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
SYNE1down-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
TACC2down-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
amp1qup-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
del13up-regulatesFOXJ3activatesR-2873-0.87110962Pr-2
NEBdown-regulatesARID5AactivatesR-599-1.149313Pr-2
TACC2down-regulatesARID5AactivatesR-599-1.149313Pr-2
del13up-regulatesARID5AactivatesR-599-1.149313Pr-2
AHNAK2down-regulatesFOXK1activatesR-1189-1.1529944Pr-2
FAT3down-regulatesFOXK1activatesR-1189-1.1529944Pr-2
MACF1down-regulatesFOXK1activatesR-1189-1.1529944Pr-2
PTPRDdown-regulatesFOXK1activatesR-1189-1.1529944Pr-2
t(4;14)up-regulatesFOXK1activatesR-1189-1.1529944Pr-2
SYNE1down-regulatesFOXK1activatesR-1189-1.1529944Pr-2
TACC2down-regulatesFOXK1activatesR-1189-1.1529944Pr-2
amp1qup-regulatesFOXK1activatesR-1189-1.1529944Pr-2
del13up-regulatesFOXK1activatesR-1189-1.1529944Pr-2
CMYA5down-regulatesZNF281activatesR-2486-1.3249611Pr-2
DMDup-regulatesZNF281activatesR-2486-1.3249611Pr-2
FAT3down-regulatesZNF281activatesR-2486-1.3249611Pr-2
t(11;14)up-regulatesZNF281activatesR-2486-1.3249611Pr-2
TACC2down-regulatesZNF281activatesR-2486-1.3249611Pr-2
amp1qup-regulatesZNF281activatesR-2486-1.3249611Pr-2
del13up-regulatesZNF281activatesR-2486-1.3249611Pr-2
t(11;14)down-regulatesHOXA5repressesR-24-1.415968Pr-2
RNASeq_FGFR3_Calldown-regulatesHOXA5repressesR-24-1.415968Pr-2
t(4;14)down-regulatesHOXA5repressesR-24-1.415968Pr-2
FAT3up-regulatesXBP1repressesR-3064-1.490686Pr-2
t(11;14)down-regulatesXBP1repressesR-3064-1.490686Pr-2
t(4;14)up-regulatesXBP1repressesR-3064-1.490686Pr-2
t(11;14)_cytogeneticdown-regulatesXBP1repressesR-3064-1.490686Pr-2
DCHS1up-regulatesATF1repressesR-570-1.501916Pr-2
DIS3up-regulatesATF1repressesR-570-1.501916Pr-2
SYNE1down-regulatesKLF7activatesR-288-2.099256Pr-2
TP53down-regulatesKLF7activatesR-288-2.099256Pr-2

Regulons in program Pr-2

Regulon Cox Hazard Ratio # genes # causal flows
R-1855-0.0570761112
R-2267-0.0655424163
R-3037-0.06989971610
R-486-0.079656378
R-2717-0.0948824324
R-8780.10173462
R-3630.103829166
R-2104-0.154186613
R-631-0.165596611
R-3178-0.173046244
R-5630.219335132
R-1911-0.246239124
R-436-0.2586451912
R-183-0.261893294
R-2977-0.272173214
R-78-0.2724183311
R-2479-0.3333682313
R-24110.33952976
R-1825-0.34360981
R-49-0.350252158
R-2720.366974115
R-390-0.37488173
R-1869-0.397022339
R-1831-0.397545199
R-2225-0.399044132
R-15860.4015583
R-7750.446924125
R-535-0.478321313
R-1660-0.495816136
R-7960.51916762
R-1574-0.538784306
R-1561-0.547918244
R-3126-0.555658298
R-2309-0.580912144
R-1717-0.584893105
R-2283-0.618728227
R-1341-0.641665183
R-2662-0.6616162
R-3007-0.81648592
R-2873-0.8711096211
R-599-1.1493133
R-1189-1.15299449
R-2486-1.32496117
R-24-1.4159683
R-3064-1.4906864
R-570-1.5019162
R-288-2.0992562

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions