Program

Causal Mechanistic Flows with regulons in program Pr-113

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
BAI3down-regulatesSOX4activatesR-2184-1.090569Pr-113
CSMD1down-regulatesSOX4activatesR-2184-1.090569Pr-113
FGFR3up-regulatesSOX4activatesR-2184-1.090569Pr-113
KDM3Bdown-regulatesSOX4activatesR-2184-1.090569Pr-113
LTBup-regulatesSOX4activatesR-2184-1.090569Pr-113
NRASdown-regulatesSOX4activatesR-2184-1.090569Pr-113
PRKD2up-regulatesSOX4activatesR-2184-1.090569Pr-113
t(11;14)down-regulatesSOX4activatesR-2184-1.090569Pr-113
RNASeq_FGFR3_Callup-regulatesSOX4activatesR-2184-1.090569Pr-113
RNASeq_MAFB_Calldown-regulatesSOX4activatesR-2184-1.090569Pr-113
t(14;16)down-regulatesSOX4activatesR-2184-1.090569Pr-113
t(4;14)up-regulatesSOX4activatesR-2184-1.090569Pr-113
RYR1down-regulatesSOX4activatesR-2184-1.090569Pr-113
SYNE2down-regulatesSOX4activatesR-2184-1.090569Pr-113
del13up-regulatesSOX4activatesR-2184-1.090569Pr-113
t(11;14)_cytogeneticdown-regulatesSOX4activatesR-2184-1.090569Pr-113
t(4;14)_cytogeneticup-regulatesSOX4activatesR-2184-1.090569Pr-113
PTPRDdown-regulatesFOXK1activatesR-1203-1.6325810Pr-113
t(4;14)up-regulatesFOXK1activatesR-1203-1.6325810Pr-113
amp1qup-regulatesFOXK1activatesR-1203-1.6325810Pr-113
del13up-regulatesFOXK1activatesR-1203-1.6325810Pr-113
KDM3Bdown-regulatesRREB1activatesR-2303-1.655497Pr-113
RNASeq_MAFB_Calldown-regulatesRREB1activatesR-2303-1.655497Pr-113
ZNF462down-regulatesRREB1activatesR-2303-1.655497Pr-113
PTPRDdown-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
RNASeq_MAFA_Calldown-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
RNASeq_MAFB_Calldown-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
t(4;14)up-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
amp1qup-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
del13up-regulatesFOXJ3activatesR-2894-1.6758411Pr-113
FGFR3up-regulatesPOU2F2activatesR-2517-1.834757Pr-113
KDM3Bdown-regulatesPOU2F2activatesR-2517-1.834757Pr-113
NRASdown-regulatesPOU2F2activatesR-2517-1.834757Pr-113
t(11;14)down-regulatesPOU2F2activatesR-2517-1.834757Pr-113
RNASeq_FGFR3_Callup-regulatesPOU2F2activatesR-2517-1.834757Pr-113
RNASeq_MAFB_Calldown-regulatesPOU2F2activatesR-2517-1.834757Pr-113
t(14;16)down-regulatesPOU2F2activatesR-2517-1.834757Pr-113
t(4;14)up-regulatesPOU2F2activatesR-2517-1.834757Pr-113
del13up-regulatesPOU2F2activatesR-2517-1.834757Pr-113
t(11;14)_cytogeneticdown-regulatesPOU2F2activatesR-2517-1.834757Pr-113
t(4;14)_cytogeneticup-regulatesPOU2F2activatesR-2517-1.834757Pr-113
BAI3down-regulatesELF4activatesR-2338-2.1124321Pr-113
FGFR3up-regulatesELF4activatesR-2338-2.1124321Pr-113
RNASeq_FGFR3_Callup-regulatesELF4activatesR-2338-2.1124321Pr-113
KDM3Bdown-regulatesRORAactivatesR-2278-2.373917Pr-113
LTBup-regulatesRORAactivatesR-2278-2.373917Pr-113
t(11;14)down-regulatesRORAactivatesR-2278-2.373917Pr-113
RYR1down-regulatesRORAactivatesR-2278-2.373917Pr-113
amp1qup-regulatesRORAactivatesR-2278-2.373917Pr-113
del13up-regulatesRORAactivatesR-2278-2.373917Pr-113
PTPRDdown-regulatesSPI1activatesR-2618-2.8659512Pr-113
MYCdown-regulatesSPI1activatesR-2618-2.8659512Pr-113
PTPRDdown-regulatesSPDEFactivatesR-1971-3.63647Pr-113
t(11;14)down-regulatesSPDEFactivatesR-1971-3.63647Pr-113
RNASeq_MAFB_Calldown-regulatesSPDEFactivatesR-1971-3.63647Pr-113
amp1qup-regulatesSPDEFactivatesR-1971-3.63647Pr-113
del13up-regulatesSPDEFactivatesR-1971-3.63647Pr-113

Regulons in program Pr-113

Regulon Cox Hazard Ratio # genes # causal flows
R-2184-1.09056917
R-1203-1.63258104
R-2303-1.6554973
R-2894-1.67584117
R-2517-1.83475711
R-2338-2.11243213
R-2278-2.3739176
R-2618-2.86595122
R-1971-3.636475

Genes in program Pr-113

EnsEMBL IdEntrez IdPreferred
ENSG00000196141 26010SPATS2L
ENSG00000205138 644096SDHAF1
ENSG00000205542 7114TMSB4X
ENSG00000206190
ENSG00000214711
ENSG00000242259 128977C22orf39
ENSG00000259384 2688GH1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions