Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation PCDH10

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TRAF4down-regulatesR-3037-0.0698997Pr-2
ELF2down-regulatesR-972-0.144871Pr-137
RUNX3down-regulatesR-891-0.153019Pr-1
ZSCAN16up-regulatesR-631-0.165596Pr-2
NR3C1down-regulatesR-3178-0.173046Pr-2
RUNX3down-regulatesR-894-0.20148Pr-14
ATF1up-regulatesR-5630.219335Pr-2
CEBPGdown-regulatesR-436-0.258645Pr-2
ELF1down-regulatesR-2977-0.272173Pr-2
ZEB1down-regulatesR-22470.272353Pr-7
ELF1down-regulatesR-2979-0.300753Pr-64
SF1down-regulatesR-1907-0.317014Pr-3
ZNF281down-regulatesR-2479-0.333368Pr-2
HBP1down-regulatesR-18280.348637Pr-124
PARP1up-regulatesR-2635-0.349554Pr-1
HBP1down-regulatesR-18390.37241Pr-23
HMBOX1down-regulatesR-23820.378178Pr-62
CEBPGdown-regulatesR-4510.388628Pr-117
HBP1down-regulatesR-1831-0.397545Pr-2
NFKB1down-regulatesR-15840.405223Pr-7
FOXP1down-regulatesR-3121-0.417258Pr-3
NFKB1down-regulatesR-1572-0.445091Pr-0
ELF4down-regulatesR-2342-0.451214Pr-120
ETV6down-regulatesR-7040.469439Pr-137
NFKB1down-regulatesR-1574-0.538784Pr-2
HMBOX1down-regulatesR-2379-0.550956Pr-3
FOXP1down-regulatesR-3126-0.555658Pr-2
ELF4down-regulatesR-23450.565136Pr-7
RUNX3down-regulatesR-890-0.585918Pr-0
NR3C1down-regulatesR-31900.592808Pr-23
NR3C1down-regulatesR-3175-0.602124Pr-0
ZNF281down-regulatesR-2472-0.661858Pr-0
NFKB1down-regulatesR-15770.685997Pr-124
ELF4down-regulatesR-2326-0.702764Pr-0
TRAF4down-regulatesR-3033-0.781484Pr-0
POU2F2up-regulatesR-2510-0.785808Pr-58
ELF2down-regulatesR-986-0.813119Pr-117
ELF2down-regulatesR-9820.82189Pr-21
ETV6down-regulatesR-717-0.825555Pr-135
FOXP1down-regulatesR-31360.83863Pr-7
NFATC2down-regulatesR-1687-0.857877Pr-0
RARAdown-regulatesR-159-0.860941Pr-9
EWSR1down-regulatesR-25420.861688Pr-1
ZEB1down-regulatesR-22380.929885Pr-136
FOXP1down-regulatesR-3119-0.932927Pr-0
SMAD4down-regulatesR-2353-0.946769Pr-58
ELF1down-regulatesR-2974-0.977147Pr-58
ZSCAN16up-regulatesR-630-0.981764Pr-117
HBP1down-regulatesR-1838-1.00343Pr-112
RARAdown-regulatesR-162-1.0531Pr-92
TRAF4down-regulatesR-30341.06768Pr-124
CEBPGdown-regulatesR-433-1.08132Pr-0
PARP1up-regulatesR-2642-1.09441Pr-99
ELF2down-regulatesR-964-1.11857Pr-58
POU2F2up-regulatesR-2509-1.12178Pr-0
EWSR1down-regulatesR-25571.12299Pr-7
RUNX3down-regulatesR-903-1.18553Pr-10
ATF1up-regulatesR-571-1.19606Pr-10
CEBPGdown-regulatesR-4441.22162Pr-23
HBP1down-regulatesR-18401.22181Pr-7
MAFKdown-regulatesR-2806-1.27994Pr-9
FOXP1down-regulatesR-31281.29587Pr-16
CEBPGdown-regulatesR-448-1.37561Pr-10
NFKB1down-regulatesR-1583-1.38564Pr-9
ELF4down-regulatesR-2340-1.40118Pr-9
ZNF281down-regulatesR-2480-1.41308Pr-9
NR3C1down-regulatesR-3193-1.45371Pr-86
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
ETV6down-regulatesR-6951.6427Pr-136
EWSR1down-regulatesR-2551-1.6617Pr-19
ZNF281down-regulatesR-2491-1.68427Pr-10
NFATC2down-regulatesR-1697-1.68436Pr-0
RARAdown-regulatesR-1561.71471Pr-16
EWSR1down-regulatesR-25501.72058Pr-56
HBP1down-regulatesR-18271.73978Pr-136
HMBOX1down-regulatesR-23771.82796Pr-5
CEBPGdown-regulatesR-452-1.91069Pr-86
CEBPGdown-regulatesR-4472.01748Pr-1
FOXP1down-regulatesR-3124-2.15985Pr-17
TRAF4down-regulatesR-3035-2.1684Pr-17
TRAF4down-regulatesR-3044-2.17055Pr-86
RELAdown-regulatesR-1463-2.30399Pr-4
RARAdown-regulatesR-1692.42125Pr-138
NFATC2down-regulatesR-16942.42215Pr-70
ETV6down-regulatesR-6932.52969Pr-72
CEBPGdown-regulatesR-4452.53867Pr-21
HBP1down-regulatesR-18372.57298Pr-21
FOXP1down-regulatesR-3132-2.58418Pr-11
HBP1down-regulatesR-1829-2.78136Pr-17
NFKB1down-regulatesR-1587-2.87374Pr-86
ATF4down-regulatesR-95-2.89504Pr-10
BACH1down-regulatesR-4762.9321Pr-21
ELF4down-regulatesR-2330-2.93229Pr-17
TEFup-regulatesR-2406-3.30554Pr-135
ZEB1down-regulatesR-2253-3.48803Pr-86
EWSR1down-regulatesR-25543.72615Pr-50
BACH1down-regulatesR-470-3.77843Pr-17
FOX3Aup-regulatesR-15143.87415Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

CEBPGdown-regulatesR-4414.14664Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ELF1down-regulatesR-29925.06585Pr-70

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions